IL108690A - Process for the Synthesis of Semi-Synthetic Glycosaminoglycans Containing A-L-Electron Acid, Converted to Nucleophilic Radicals at Position 3 - Google Patents

Process for the Synthesis of Semi-Synthetic Glycosaminoglycans Containing A-L-Electron Acid, Converted to Nucleophilic Radicals at Position 3

Info

Publication number
IL108690A
IL108690A IL108690A IL10869094A IL108690A IL 108690 A IL108690 A IL 108690A IL 108690 A IL108690 A IL 108690A IL 10869094 A IL10869094 A IL 10869094A IL 108690 A IL108690 A IL 108690A
Authority
IL
Israel
Prior art keywords
acid
general formula
nucleophilic
aqueous solution
glycosaminoglycans
Prior art date
Application number
IL108690A
Other languages
English (en)
Hebrew (he)
Other versions
IL108690A0 (en
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of IL108690A0 publication Critical patent/IL108690A0/xx
Publication of IL108690A publication Critical patent/IL108690A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL108690A 1993-03-29 1994-02-17 Process for the Synthesis of Semi-Synthetic Glycosaminoglycans Containing A-L-Electron Acid, Converted to Nucleophilic Radicals at Position 3 IL108690A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93BO000126A IT1264102B1 (it) 1993-03-29 1993-03-29 Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali

Publications (2)

Publication Number Publication Date
IL108690A0 IL108690A0 (en) 1994-05-30
IL108690A true IL108690A (en) 1998-02-22

Family

ID=11338860

Family Applications (1)

Application Number Title Priority Date Filing Date
IL108690A IL108690A (en) 1993-03-29 1994-02-17 Process for the Synthesis of Semi-Synthetic Glycosaminoglycans Containing A-L-Electron Acid, Converted to Nucleophilic Radicals at Position 3

Country Status (18)

Country Link
US (1) US5410039A (ja)
EP (1) EP0618235B1 (ja)
JP (1) JP2726620B2 (ja)
KR (1) KR100191885B1 (ja)
AT (1) ATE155798T1 (ja)
AU (1) AU664938B2 (ja)
CA (1) CA2114863C (ja)
DE (1) DE69404353T2 (ja)
DK (1) DK0618235T3 (ja)
ES (1) ES2105382T3 (ja)
FI (1) FI105100B (ja)
GR (1) GR3024710T3 (ja)
IL (1) IL108690A (ja)
IT (1) IT1264102B1 (ja)
NO (1) NO305993B1 (ja)
NZ (1) NZ250816A (ja)
TW (1) TW266216B (ja)
ZA (1) ZA94892B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255295B1 (en) 1996-12-23 2001-07-03 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
CA2435637A1 (en) 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
EP2402753A1 (en) * 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2526122B1 (en) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2017154938A1 (ja) * 2016-03-09 2017-09-14 株式会社糖鎖工学研究所 硫酸基および／またはリン酸基を有する糖の製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1242604B (it) * 1990-11-13 1994-05-16 Alfa Wassermann Spa Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono.
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
AU5504594A (en) * 1993-02-08 1994-08-11 Applied Sorting Technologies Pty Ltd Metal detection in highly mineralised ground

Also Published As

Publication number Publication date
NO941129L (no) 1994-09-30
ES2105382T3 (es) 1997-10-16
FI941432A0 (fi) 1994-03-28
FI105100B (fi) 2000-06-15
DE69404353D1 (de) 1997-09-04
FI941432A (fi) 1994-09-30
NO941129D0 (no) 1994-03-28
ATE155798T1 (de) 1997-08-15
TW266216B (ja) 1995-12-21
CA2114863C (en) 1999-07-20
DE69404353T2 (de) 1997-11-13
ITBO930126A1 (it) 1994-09-29
KR100191885B1 (ko) 1999-06-15
AU664938B2 (en) 1995-12-07
EP0618235B1 (en) 1997-07-23
AU5508494A (en) 1994-10-06
GR3024710T3 (en) 1997-12-31
ZA94892B (en) 1994-08-23
KR940021583A (ko) 1994-10-19
IL108690A0 (en) 1994-05-30
EP0618235A1 (en) 1994-10-05
JPH06322002A (ja) 1994-11-22
NZ250816A (en) 1996-02-27
ITBO930126A0 (it) 1993-03-29
CA2114863A1 (en) 1994-09-30
NO305993B1 (no) 1999-08-30
JP2726620B2 (ja) 1998-03-11
IT1264102B1 (it) 1996-09-10
DK0618235T3 (da) 1998-01-26
US5410039A (en) 1995-04-25

Similar Documents

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AU658498B2 (en) Semi-synthetic glycosaminoglycans with heparin or heparan structure of alpha-L-iduronic-2-sulfate acid modified in position 2
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US5410039A (en) Process for the synthesis of glycosaminoglycans containing α-L-galacturonic acid substituted with nucleophilic groups in position 3
EP0618234B1 (en) Process for the synthesis of semisynthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-0-sulfate acid
JPWO2003070960A1 (ja) コンドロイチン又はコンドロイチン誘導体の製造法

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