IL106520A - FLUORINATED 17b-SUBSTITUTED 4-AZA-5a- ANDROSTANE- 3-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

FLUORINATED 17b-SUBSTITUTED 4-AZA-5a- ANDROSTANE- 3-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IL106520A
IL106520A IL106520A IL10652093A IL106520A IL 106520 A IL106520 A IL 106520A IL 106520 A IL106520 A IL 106520A IL 10652093 A IL10652093 A IL 10652093A IL 106520 A IL106520 A IL 106520A
Authority
IL
Israel
Prior art keywords
hydrogen
fluorine
alkyl
androstane
aza
Prior art date
Application number
IL106520A
Other languages
English (en)
Other versions
IL106520A0 (en
Inventor
Achille Panzeri
Marcella Nesi
Enrico Di Salle
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of IL106520A0 publication Critical patent/IL106520A0/xx
Publication of IL106520A publication Critical patent/IL106520A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Glass Compositions (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL106520A 1992-07-31 1993-07-29 FLUORINATED 17b-SUBSTITUTED 4-AZA-5a- ANDROSTANE- 3-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL106520A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929216284A GB9216284D0 (en) 1992-07-31 1992-07-31 Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Publications (2)

Publication Number Publication Date
IL106520A0 IL106520A0 (en) 1993-11-15
IL106520A true IL106520A (en) 1997-11-20

Family

ID=10719598

Family Applications (1)

Application Number Title Priority Date Filing Date
IL106520A IL106520A (en) 1992-07-31 1993-07-29 FLUORINATED 17b-SUBSTITUTED 4-AZA-5a- ANDROSTANE- 3-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (28)

Country Link
US (1) US5407939A (cs)
EP (1) EP0607400B1 (cs)
JP (1) JP3325025B2 (cs)
KR (1) KR100311547B1 (cs)
CN (1) CN1041096C (cs)
AT (1) ATE159951T1 (cs)
AU (1) AU660562B2 (cs)
CA (1) CA2120343A1 (cs)
CZ (1) CZ286240B6 (cs)
DE (1) DE69315050T2 (cs)
DK (1) DK0607400T3 (cs)
ES (1) ES2110620T3 (cs)
FI (1) FI113778B (cs)
GB (1) GB9216284D0 (cs)
GR (1) GR3025546T3 (cs)
HU (2) HUT67043A (cs)
IL (1) IL106520A (cs)
MX (1) MX9304579A (cs)
MY (1) MY109633A (cs)
NO (1) NO305401B1 (cs)
NZ (1) NZ254787A (cs)
PH (1) PH29938A (cs)
PL (1) PL178591B1 (cs)
RU (1) RU2125061C1 (cs)
TW (1) TW286319B (cs)
UA (1) UA41291C2 (cs)
WO (1) WO1994003475A1 (cs)
ZA (1) ZA935481B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE203162T1 (de) * 1992-12-18 2001-08-15 Merck & Co Inc Verfahren zur behandlung von chronischer prostatitis mit 17-beta-n-tertbutylcarbamoyl-4- aza-5 alpha-androst-1-en-3-one
CA2166090C (en) * 1993-06-24 2006-01-24 Zoltan Tuba Novel process for preparing 17.beta.-substituted 4-azaandrostane derivatives
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
RU2142956C1 (ru) * 1993-10-21 1999-12-20 Мерк Энд Ко., Инк. 16-замещенные 4-аза-андростаны, соединения, способы ингибирования, фармацевтическая композиция
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
IT1275594B1 (it) * 1995-07-21 1997-08-06 Pharmacia S P A Ora Pharmacia Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide
GB9518858D0 (en) * 1995-09-14 1995-11-15 Pharmacia Spa Phenylsubstituted 4-azasteroid fluoroderivatives
GB9727522D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Process for preparing carboxamido-4-azasteroids
US6645974B2 (en) * 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
HRP20040822A2 (en) * 2002-03-13 2005-06-30 Merck & Co. Inc. Fluorinated 4-azasteroid derivatives as androgen receptor modulators
EP1660184A4 (en) 2003-06-30 2008-05-14 Merck & Co Inc 17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS MODULATORS OF THE ANDROGEN RECEPTOR
WO2005004807A2 (en) * 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
CN1816370A (zh) * 2003-06-30 2006-08-09 麦克公司 用作雄激素受体调节剂的17－乙酰氨基－4－氮杂甾族化合物衍生物
CN100528168C (zh) * 2003-06-30 2009-08-19 麦克公司 作为雄激素受体调节剂的17-乙酰氨基-4-氮杂甾类衍生物
WO2005025572A1 (en) * 2003-09-10 2005-03-24 Merck & Co., Inc. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators
EP1670483A4 (en) 2003-09-10 2010-02-17 Merck & Co Inc 17-heterocyclic 4-azasteroid derivatives as androgen receptor modules
CA2562132A1 (en) * 2004-04-08 2005-10-27 Merck & Co., Inc. 17 beta-acetamide-4-azasteroids as androgen receptor modulators
US20100105700A1 (en) * 2008-10-28 2010-04-29 Lead Therapeutics, Inc. Decahydro-1h-indenoquinolinone and decahydro-3h-cyclopentaphenanthridinone cyp17 inhibitors
KR102541494B1 (ko) 2019-09-11 2023-06-08 주식회사 엘지화학 고흡수성 수지의 제조 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74365A (en) * 1984-02-27 1990-07-26 Merck & Co Inc 17beta-(n-t.-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one and pharmaceutical compositions containing it
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
AUPP930799A0 (en) * 1999-03-18 1999-04-15 University Of Sydney, The Optical planar waveguide device and method of its fabrication

Also Published As

Publication number Publication date
FI941424A7 (fi) 1994-05-27
GR3025546T3 (en) 1998-03-31
NO941080D0 (no) 1994-03-24
DE69315050D1 (de) 1997-12-11
CZ286240B6 (cs) 2000-02-16
MX9304579A (es) 1994-02-28
CA2120343A1 (en) 1994-02-17
ATE159951T1 (de) 1997-11-15
HK1011693A1 (en) 1999-07-16
US5407939A (en) 1995-04-18
GB9216284D0 (en) 1992-09-16
CN1041096C (zh) 1998-12-09
UA41291C2 (uk) 2001-09-17
CZ153893A3 (en) 1994-02-16
PL178591B1 (pl) 2000-05-31
RU2125061C1 (ru) 1999-01-20
NO941080L (no) 1994-05-18
TW286319B (cs) 1996-09-21
FI113778B (fi) 2004-06-15
CN1085224A (zh) 1994-04-13
AU4704893A (en) 1994-03-03
AU660562B2 (en) 1995-06-29
EP0607400B1 (en) 1997-11-05
EP0607400A1 (en) 1994-07-27
IL106520A0 (en) 1993-11-15
DK0607400T3 (da) 1998-01-26
JP3325025B2 (ja) 2002-09-17
HU211238A9 (en) 1995-11-28
ES2110620T3 (es) 1998-02-16
PH29938A (en) 1996-09-16
HUT67043A (en) 1995-01-30
MY109633A (en) 1997-03-31
FI941424A0 (fi) 1994-03-28
NO305401B1 (no) 1999-05-25
ZA935481B (en) 1994-05-16
KR100311547B1 (ko) 2002-06-20
JPH06511497A (ja) 1994-12-22
NZ254787A (en) 1995-11-27
WO1994003475A1 (en) 1994-02-17
DE69315050T2 (de) 1998-03-05
HU9400914D0 (en) 1994-06-28

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Legal Events

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RH Patent void
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MM9K Patent not in force due to non-payment of renewal fees