DK0607400T3 - Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater - Google Patents

Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater

Info

Publication number
DK0607400T3
DK0607400T3 DK93917705.1T DK93917705T DK0607400T3 DK 0607400 T3 DK0607400 T3 DK 0607400T3 DK 93917705 T DK93917705 T DK 93917705T DK 0607400 T3 DK0607400 T3 DK 0607400T3
Authority
DK
Denmark
Prior art keywords
hydrogen
fluorine
alkyl
17beta
androstan
Prior art date
Application number
DK93917705.1T
Other languages
Danish (da)
English (en)
Inventor
Achille Panzeri
Marcella Nesi
Salle Enrico Di
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of DK0607400T3 publication Critical patent/DK0607400T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Glass Compositions (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK93917705.1T 1992-07-31 1993-07-29 Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater DK0607400T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929216284A GB9216284D0 (en) 1992-07-31 1992-07-31 Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Publications (1)

Publication Number Publication Date
DK0607400T3 true DK0607400T3 (da) 1998-01-26

Family

ID=10719598

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93917705.1T DK0607400T3 (da) 1992-07-31 1993-07-29 Fluorerede 17beta-substituerede 4-aza-5-alfa-androstan-3-on-derivater

Country Status (28)

Country Link
US (1) US5407939A (cs)
EP (1) EP0607400B1 (cs)
JP (1) JP3325025B2 (cs)
KR (1) KR100311547B1 (cs)
CN (1) CN1041096C (cs)
AT (1) ATE159951T1 (cs)
AU (1) AU660562B2 (cs)
CA (1) CA2120343A1 (cs)
CZ (1) CZ286240B6 (cs)
DE (1) DE69315050T2 (cs)
DK (1) DK0607400T3 (cs)
ES (1) ES2110620T3 (cs)
FI (1) FI113778B (cs)
GB (1) GB9216284D0 (cs)
GR (1) GR3025546T3 (cs)
HU (2) HUT67043A (cs)
IL (1) IL106520A (cs)
MX (1) MX9304579A (cs)
MY (1) MY109633A (cs)
NO (1) NO305401B1 (cs)
NZ (1) NZ254787A (cs)
PH (1) PH29938A (cs)
PL (1) PL178591B1 (cs)
RU (1) RU2125061C1 (cs)
TW (1) TW286319B (cs)
UA (1) UA41291C2 (cs)
WO (1) WO1994003475A1 (cs)
ZA (1) ZA935481B (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU691164B2 (en) * 1992-12-18 1998-05-14 Merck & Co., Inc. Method of treatment of chronic prostatitis with 17beta -N-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-E N-3-ones
CA2166090C (en) * 1993-06-24 2006-01-24 Zoltan Tuba Novel process for preparing 17.beta.-substituted 4-azaandrostane derivatives
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
IL111357A (en) * 1993-10-21 2001-01-28 Merck & Co Inc 16-Substituted-4-aza-androstanes their preparation and pharmaceutical compositions containing them
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
IT1275594B1 (it) * 1995-07-21 1997-08-06 Pharmacia S P A Ora Pharmacia Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide
GB9518858D0 (en) * 1995-09-14 1995-11-15 Pharmacia Spa Phenylsubstituted 4-azasteroid fluoroderivatives
GB9727522D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Process for preparing carboxamido-4-azasteroids
US6645974B2 (en) * 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
JP4516316B2 (ja) * 2002-03-13 2010-08-04 メルク・シャープ・エンド・ドーム・コーポレイション アンドロゲン受容体モジュレーターとしてのフッ化４−アザステロイド誘導体
EP1641464A4 (en) * 2003-06-30 2008-05-14 Merck & Co Inc 17-ACETAMIDO-4-AZASTEROIDE DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS
CN1816528A (zh) * 2003-06-30 2006-08-09 麦克公司 作为雄激素受体调节剂的17－乙酰氨基－4－氮杂甾类衍生物
EP1641535A4 (en) * 2003-06-30 2008-05-14 Merck & Co Inc 17-ACETAMIDO-4-AZASTEROID DERIVATIVES AS ANDROGEN RECEPTOR MODULATORS
CN1812824A (zh) 2003-06-30 2006-08-02 麦克公司 作为雄激素受体调节剂的17－乙酰氨基－4－氮杂甾体衍生物
EP1670483A4 (en) 2003-09-10 2010-02-17 Merck & Co Inc 17-heterocyclic 4-azasteroid derivatives as androgen receptor modules
CN1849120A (zh) * 2003-09-10 2006-10-18 默克公司 作为雄激素受体调节剂的17－杂环－4－氮杂甾类衍生物
EP1734964A4 (en) * 2004-04-08 2009-06-17 Merck & Co Inc 17-BETA-ACETAMIDE-4-AZASTEROIDS AS ANDROGEN RECEPTOR MODULATORS
JP2012506906A (ja) * 2008-10-28 2012-03-22 バイオマリン ファーマシューティカル インコーポレイテッド デカヒドロ−１ｈ−インデノキノリンおよびデカヒドロ−３ｈ−シクロペンタフェナントリジノンｃｙｐ１７インヒビター
KR102541494B1 (ko) 2019-09-11 2023-06-08 주식회사 엘지화학 고흡수성 수지의 제조 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
AUPP930799A0 (en) * 1999-03-18 1999-04-15 University Of Sydney, The Optical planar waveguide device and method of its fabrication

Also Published As

Publication number Publication date
UA41291C2 (uk) 2001-09-17
RU2125061C1 (ru) 1999-01-20
GB9216284D0 (en) 1992-09-16
GR3025546T3 (en) 1998-03-31
HK1011693A1 (en) 1999-07-16
ATE159951T1 (de) 1997-11-15
KR100311547B1 (ko) 2002-06-20
NO941080L (no) 1994-05-18
TW286319B (cs) 1996-09-21
ZA935481B (en) 1994-05-16
PL178591B1 (pl) 2000-05-31
NZ254787A (en) 1995-11-27
AU4704893A (en) 1994-03-03
MY109633A (en) 1997-03-31
MX9304579A (es) 1994-02-28
IL106520A0 (en) 1993-11-15
AU660562B2 (en) 1995-06-29
FI113778B (fi) 2004-06-15
CN1085224A (zh) 1994-04-13
JPH06511497A (ja) 1994-12-22
HU9400914D0 (en) 1994-06-28
EP0607400A1 (en) 1994-07-27
EP0607400B1 (en) 1997-11-05
DE69315050T2 (de) 1998-03-05
HU211238A9 (en) 1995-11-28
CZ286240B6 (cs) 2000-02-16
NO305401B1 (no) 1999-05-25
JP3325025B2 (ja) 2002-09-17
PH29938A (en) 1996-09-16
CZ153893A3 (en) 1994-02-16
DE69315050D1 (de) 1997-12-11
CN1041096C (zh) 1998-12-09
ES2110620T3 (es) 1998-02-16
WO1994003475A1 (en) 1994-02-17
FI941424A0 (fi) 1994-03-28
FI941424A7 (fi) 1994-05-27
HUT67043A (en) 1995-01-30
CA2120343A1 (en) 1994-02-17
NO941080D0 (no) 1994-03-24
IL106520A (en) 1997-11-20
US5407939A (en) 1995-04-18

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