IL105885A - Analogs with a spatial structure are limited as antifungal preparations - Google Patents

Analogs with a spatial structure are limited as antifungal preparations

Info

Publication number
IL105885A
IL105885A IL10588593A IL10588593A IL105885A IL 105885 A IL105885 A IL 105885A IL 10588593 A IL10588593 A IL 10588593A IL 10588593 A IL10588593 A IL 10588593A IL 105885 A IL105885 A IL 105885A
Authority
IL
Israel
Prior art keywords
asp
gly
arg
chxl
amino acid
Prior art date
Application number
IL10588593A
Other languages
English (en)
Hebrew (he)
Other versions
IL105885A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL105885A0 publication Critical patent/IL105885A0/xx
Publication of IL105885A publication Critical patent/IL105885A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10588593A 1992-06-04 1993-06-02 Analogs with a spatial structure are limited as antifungal preparations IL105885A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89421492A 1992-06-04 1992-06-04
US5611193A 1993-05-07 1993-05-07

Publications (2)

Publication Number Publication Date
IL105885A0 IL105885A0 (en) 1993-10-20
IL105885A true IL105885A (en) 1999-06-20

Family

ID=26734982

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10588593A IL105885A (en) 1992-06-04 1993-06-02 Analogs with a spatial structure are limited as antifungal preparations

Country Status (16)

Country Link
US (1) US6107275A (de)
EP (1) EP0648224B1 (de)
JP (1) JP3398747B2 (de)
KR (1) KR100297184B1 (de)
AT (1) ATE168380T1 (de)
AU (1) AU672010B2 (de)
CA (1) CA2137072C (de)
DE (1) DE69319733T2 (de)
DK (1) DK0648224T3 (de)
ES (1) ES2121088T3 (de)
GR (1) GR3027738T3 (de)
IL (1) IL105885A (de)
MX (1) MX9303332A (de)
NZ (1) NZ253452A (de)
TW (1) TW274085B (de)
WO (1) WO1993024520A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
DK0729362T3 (da) * 1993-11-19 2000-05-08 Searle & Co Transdermal sammensætning af N-(N-(5-(4-aminoiminomethyl)-phenyl)-1-oxypentyl)-L-alfa-aspartyl)-L-phenylalanin eller estere
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
DE19653036A1 (de) * 1996-12-19 1998-06-25 Merck Patent Gmbh Cyclopeptidderivate
DE19728524A1 (de) 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
WO2011115688A2 (en) 2010-03-19 2011-09-22 H. Lee Moffitt Cancer Center & Research Institute Integrin interaction inhibitors for the treatment of cancer
WO2015048477A1 (en) 2013-09-27 2015-04-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Cyclic peptide conjugates and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1585061A (en) * 1977-03-15 1981-02-25 Nat Res Dev Synthesis of peptides
US5041380A (en) * 1982-08-04 1991-08-20 La Jolla Cancer Research Foundation Tetrapeptide
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
FI84025C (fi) * 1989-06-30 1991-10-10 Jukka Elias Saarikettu Filter som taol hoega temperaturer och foerfarande foer framstaellning daerav.
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2021951A1 (en) * 1989-07-28 1991-01-29 Ruth F. Nutt Fibrinogen receptor antagonists
EP0410541A1 (de) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogenrezeptorantagonisten
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds

Also Published As

Publication number Publication date
IL105885A0 (en) 1993-10-20
DK0648224T3 (da) 1998-10-26
US6107275A (en) 2000-08-22
GR3027738T3 (en) 1998-11-30
CA2137072C (en) 2000-06-13
DE69319733T2 (de) 1999-01-14
JPH07507310A (ja) 1995-08-10
JP3398747B2 (ja) 2003-04-21
DE69319733D1 (de) 1998-08-20
EP0648224B1 (de) 1998-07-15
TW274085B (de) 1996-04-11
MX9303332A (es) 1994-06-30
AU672010B2 (en) 1996-09-19
AU4378393A (en) 1993-12-30
KR950701935A (ko) 1995-05-17
ES2121088T3 (es) 1998-11-16
NZ253452A (en) 1996-06-25
EP0648224A1 (de) 1995-04-19
CA2137072A1 (en) 1993-12-09
KR100297184B1 (ko) 2001-10-22
ATE168380T1 (de) 1998-08-15
WO1993024520A1 (en) 1993-12-09

Similar Documents

Publication Publication Date Title
FI120494B (fi) Tekijän Xa inhibiittoreita
CA2155931C (en) Inhibitors of thrombosis
US5866681A (en) Thrombin receptor antagonists
CA2064473C (en) Chimeric amino acids and peptides containing these analogues
CA2146446A1 (en) Arginine keto-amide enzyme inhibitors
WO1991001331A1 (en) Small cyclic platelet aggregation inhibitors
AU672010B2 (en) Conformationally restrained peptide analogs as antiplatelet agents
WO1996040743A2 (en) INHIBITORS OF FACTOR Xa
KR0154528B1 (ko) 항응고성 펩티드
JP2916164B2 (ja) 抗凝固剤ペプチドアルコール類
JP2949129B2 (ja) 胃腸運動刺激活性を有するモチリン類似ポリペプチド
AU641215B2 (en) Stabilized sulfonate, sulfate, phosphonate and phosphate derivatives of hirudin
HU199877B (en) Process for producing new anf derivatives and pharmaceutical compositions comprising same
US5192747A (en) Anticoagulant peptides
CA2164712C (en) Trifunctional antithrombin and antiplatelet peptides
US6218364B1 (en) Fluorinated neurokinin A antagonists
US5574012A (en) Analogs of hirudin having anti-platelet activity
CA2192686A1 (en) Arginine mimic derivatives as enzyme inhibitors
Bladon Analogue and conformational studies on peptide hormones and other biologically active peptides

Legal Events

Date Code Title Description
FF Patent granted
RH1 Patent not in force