MX9303332A - Analogos de peptidos conformacionalmente restringidos, como agentes antiplaquetarios. - Google Patents
Analogos de peptidos conformacionalmente restringidos, como agentes antiplaquetarios.Info
- Publication number
- MX9303332A MX9303332A MX9303332A MX9303332A MX9303332A MX 9303332 A MX9303332 A MX 9303332A MX 9303332 A MX9303332 A MX 9303332A MX 9303332 A MX9303332 A MX 9303332A MX 9303332 A MX9303332 A MX 9303332A
- Authority
- MX
- Mexico
- Prior art keywords
- peptides
- platelet agents
- conformationally restricted
- platelet aggregation
- restricted analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se relaciona con análogos de péptidos conformacionalmente restringidos como inhibidores de la agregación plaquetaria. Estos compuestos inhiben el enlace del fibrinógeno al receptor integrina GPIIb-IIIa de las plaquetas, el cual inhibe la agregación plaquetaria y por lo tanto estos compuestos actúan como antitrombóticos potentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89421492A | 1992-06-04 | 1992-06-04 | |
US5611193A | 1993-05-07 | 1993-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9303332A true MX9303332A (es) | 1994-06-30 |
Family
ID=26734982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9303332A MX9303332A (es) | 1992-06-04 | 1993-06-03 | Analogos de peptidos conformacionalmente restringidos, como agentes antiplaquetarios. |
Country Status (16)
Country | Link |
---|---|
US (1) | US6107275A (es) |
EP (1) | EP0648224B1 (es) |
JP (1) | JP3398747B2 (es) |
KR (1) | KR100297184B1 (es) |
AT (1) | ATE168380T1 (es) |
AU (1) | AU672010B2 (es) |
CA (1) | CA2137072C (es) |
DE (1) | DE69319733T2 (es) |
DK (1) | DK0648224T3 (es) |
ES (1) | ES2121088T3 (es) |
GR (1) | GR3027738T3 (es) |
IL (1) | IL105885A (es) |
MX (1) | MX9303332A (es) |
NZ (1) | NZ253452A (es) |
TW (1) | TW274085B (es) |
WO (1) | WO1993024520A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843156A (en) * | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
PT729362E (pt) * | 1993-11-19 | 2000-06-30 | Searle & Co | Composicao transdermica de n-¬n-¬5-¬4-(aminoiminometil)fenil|-1oxopentil|-l-alfa-aspartil|-l-fenillalanina ou esteres e seus sais farmaceuticamente aceitaveis |
US6387880B1 (en) | 1994-10-24 | 2002-05-14 | G.D. Searle & Co. | Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts |
DE19653036A1 (de) * | 1996-12-19 | 1998-06-25 | Merck Patent Gmbh | Cyclopeptidderivate |
DE19728524A1 (de) | 1997-07-04 | 1999-01-07 | Merck Patent Gmbh | Cyclische Azapeptide |
CA2284459C (en) | 1999-10-04 | 2012-12-11 | Neokimia Inc. | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery |
CA2793838C (en) | 2010-03-19 | 2019-09-17 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Integrin interaction inhibitors for the treatment of cancer |
US10011635B2 (en) | 2013-09-27 | 2018-07-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1585061A (en) * | 1977-03-15 | 1981-02-25 | Nat Res Dev | Synthesis of peptides |
US5041380A (en) * | 1982-08-04 | 1991-08-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
FI84025C (fi) * | 1989-06-30 | 1991-10-10 | Jukka Elias Saarikettu | Filter som taol hoega temperaturer och foerfarande foer framstaellning daerav. |
US5384309A (en) * | 1989-07-17 | 1995-01-24 | Genentech, Inc. | Cyclized peptides and their use as platelet aggregation inhibitors |
CA2021950A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
CA2021951A1 (en) * | 1989-07-28 | 1991-01-29 | Ruth F. Nutt | Fibrinogen receptor antagonists |
US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5192746A (en) * | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
-
1993
- 1993-05-14 EP EP93913930A patent/EP0648224B1/en not_active Expired - Lifetime
- 1993-05-14 CA CA002137072A patent/CA2137072C/en not_active Expired - Fee Related
- 1993-05-14 DE DE69319733T patent/DE69319733T2/de not_active Expired - Fee Related
- 1993-05-14 AT AT93913930T patent/ATE168380T1/de not_active IP Right Cessation
- 1993-05-14 JP JP50059594A patent/JP3398747B2/ja not_active Expired - Fee Related
- 1993-05-14 DK DK93913930T patent/DK0648224T3/da active
- 1993-05-14 KR KR1019940704404A patent/KR100297184B1/ko not_active IP Right Cessation
- 1993-05-14 NZ NZ253452A patent/NZ253452A/en unknown
- 1993-05-14 WO PCT/US1993/004660 patent/WO1993024520A1/en active IP Right Grant
- 1993-05-14 ES ES93913930T patent/ES2121088T3/es not_active Expired - Lifetime
- 1993-05-14 AU AU43783/93A patent/AU672010B2/en not_active Ceased
- 1993-06-01 TW TW082104342A patent/TW274085B/zh active
- 1993-06-02 IL IL10588593A patent/IL105885A/en not_active IP Right Cessation
- 1993-06-03 MX MX9303332A patent/MX9303332A/es unknown
-
1997
- 1997-04-09 US US08/835,274 patent/US6107275A/en not_active Expired - Fee Related
-
1998
- 1998-08-26 GR GR980401921T patent/GR3027738T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU4378393A (en) | 1993-12-30 |
DE69319733T2 (de) | 1999-01-14 |
CA2137072C (en) | 2000-06-13 |
CA2137072A1 (en) | 1993-12-09 |
JPH07507310A (ja) | 1995-08-10 |
KR100297184B1 (ko) | 2001-10-22 |
KR950701935A (ko) | 1995-05-17 |
IL105885A (en) | 1999-06-20 |
US6107275A (en) | 2000-08-22 |
JP3398747B2 (ja) | 2003-04-21 |
GR3027738T3 (en) | 1998-11-30 |
ATE168380T1 (de) | 1998-08-15 |
TW274085B (es) | 1996-04-11 |
EP0648224B1 (en) | 1998-07-15 |
DK0648224T3 (da) | 1998-10-26 |
EP0648224A1 (en) | 1995-04-19 |
DE69319733D1 (de) | 1998-08-20 |
IL105885A0 (en) | 1993-10-20 |
ES2121088T3 (es) | 1998-11-16 |
WO1993024520A1 (en) | 1993-12-09 |
AU672010B2 (en) | 1996-09-19 |
NZ253452A (en) | 1996-06-25 |
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