DK0648224T3 - Konformationsbegrænsede peptidanaloger som aktivestoffer mod blodpladeaggregation - Google Patents

Konformationsbegrænsede peptidanaloger som aktivestoffer mod blodpladeaggregation

Info

Publication number
DK0648224T3
DK0648224T3 DK93913930T DK93913930T DK0648224T3 DK 0648224 T3 DK0648224 T3 DK 0648224T3 DK 93913930 T DK93913930 T DK 93913930T DK 93913930 T DK93913930 T DK 93913930T DK 0648224 T3 DK0648224 T3 DK 0648224T3
Authority
DK
Denmark
Prior art keywords
platelet aggregation
peptide analogs
active substances
substances against
against platelet
Prior art date
Application number
DK93913930T
Other languages
English (en)
Inventor
Scott L Harbeson
Alan J Bitonti
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0648224T3 publication Critical patent/DK0648224T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK93913930T 1992-06-04 1993-05-14 Konformationsbegrænsede peptidanaloger som aktivestoffer mod blodpladeaggregation DK0648224T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89421492A 1992-06-04 1992-06-04
US5611193A 1993-05-07 1993-05-07
PCT/US1993/004660 WO1993024520A1 (en) 1992-06-04 1993-05-14 Conformationally restrained peptide analogs as antiplatelet agents

Publications (1)

Publication Number Publication Date
DK0648224T3 true DK0648224T3 (da) 1998-10-26

Family

ID=26734982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93913930T DK0648224T3 (da) 1992-06-04 1993-05-14 Konformationsbegrænsede peptidanaloger som aktivestoffer mod blodpladeaggregation

Country Status (16)

Country Link
US (1) US6107275A (da)
EP (1) EP0648224B1 (da)
JP (1) JP3398747B2 (da)
KR (1) KR100297184B1 (da)
AT (1) ATE168380T1 (da)
AU (1) AU672010B2 (da)
CA (1) CA2137072C (da)
DE (1) DE69319733T2 (da)
DK (1) DK0648224T3 (da)
ES (1) ES2121088T3 (da)
GR (1) GR3027738T3 (da)
IL (1) IL105885A (da)
MX (1) MX9303332A (da)
NZ (1) NZ253452A (da)
TW (1) TW274085B (da)
WO (1) WO1993024520A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
JPH09505290A (ja) * 1993-11-19 1997-05-27 ジー．ディー．サール アンド カンパニー Ｎ‐［Ｎ‐［５‐［４‐（アミノイミノメチル）フェニル］‐１‐オキソペンチル］‐Ｌ‐α‐アスパルチル］‐Ｌ‐フェニルアラニンまたはそのエステル並びにそれらの医薬的に許容される塩類の経皮的組成物
US6387880B1 (en) 1994-10-24 2002-05-14 G.D. Searle & Co. Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts
DE19653036A1 (de) * 1996-12-19 1998-06-25 Merck Patent Gmbh Cyclopeptidderivate
DE19728524A1 (de) * 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
WO2011115688A2 (en) 2010-03-19 2011-09-22 H. Lee Moffitt Cancer Center & Research Institute Integrin interaction inhibitors for the treatment of cancer
WO2015048477A1 (en) 2013-09-27 2015-04-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Cyclic peptide conjugates and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1585061A (en) * 1977-03-15 1981-02-25 Nat Res Dev Synthesis of peptides
US5041380A (en) * 1982-08-04 1991-08-20 La Jolla Cancer Research Foundation Tetrapeptide
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
FI84025C (fi) * 1989-06-30 1991-10-10 Jukka Elias Saarikettu Filter som taol hoega temperaturer och foerfarande foer framstaellning daerav.
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0410541A1 (en) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogen receptor antagonists
EP0410540A1 (en) * 1989-07-28 1991-01-30 Merck & Co. Inc. Fibrinogen receptor antagonists
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds

Also Published As

Publication number Publication date
ES2121088T3 (es) 1998-11-16
GR3027738T3 (en) 1998-11-30
NZ253452A (en) 1996-06-25
KR100297184B1 (ko) 2001-10-22
US6107275A (en) 2000-08-22
KR950701935A (ko) 1995-05-17
EP0648224B1 (en) 1998-07-15
DE69319733T2 (de) 1999-01-14
IL105885A (en) 1999-06-20
CA2137072A1 (en) 1993-12-09
TW274085B (da) 1996-04-11
DE69319733D1 (de) 1998-08-20
AU4378393A (en) 1993-12-30
JP3398747B2 (ja) 2003-04-21
MX9303332A (es) 1994-06-30
CA2137072C (en) 2000-06-13
AU672010B2 (en) 1996-09-19
IL105885A0 (en) 1993-10-20
WO1993024520A1 (en) 1993-12-09
JPH07507310A (ja) 1995-08-10
EP0648224A1 (en) 1995-04-19
ATE168380T1 (de) 1998-08-15

Similar Documents

Publication Publication Date Title
NL1002835A1 (nl) Synergistisch stabilisatormengsel.
ES2155518T3 (es) Compuestos antimicrobianos de amplio espectro y metodo de uso.
UA39099C2 (uk) Циклічні азотовмісні похідні, суміш їх ізомерів або окремі ізомери, або їх солі
HU9301950D0 (en) Adhesion inhibiting medical preparatives containing cyclic peptides
IL123164A (en) Meta-guanidine urea thiourea or azacyclic amino benzoic acid derivatives and pharmaceutical compositions containing them
DE3574014D1 (en) Novel biologically active compound having anti-prolyl endopeptidase activity
EP0201742A3 (en) N-acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use
BR9803179A (pt) Antagonistas receptores de ccr-3.
ES535842A0 (es) Un procedimiento para preparar octapeptidos lineales
DK0648224T3 (da) Konformationsbegrænsede peptidanaloger som aktivestoffer mod blodpladeaggregation
AU4348893A (en) Neuropeptide y antagonists
FI941457A (fi) Verihiutaleglyproteiini IIb/IIIa:n inhibiittoreina käyttökelpoisia syklisiä yhdisteitä
WO1998010786A3 (en) Pharmaceutical composition for the treatment of syndrome x of reaven
ES2133295T3 (es) Peptidos ciclicos y su uso.
NO302072B1 (no) Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og preparater inneholdende slike
HUT55054A (en) Process for producing new antibioticum mersadicin and salts and pharmaceutical compositions containing them as active components
NO20000424D0 (no) Streptograminer, deres fremstilling samt preparater inneholdende forbindelsene
NO973341L (no) Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for vasodilatorisk behandling eller profylakse
SE9304065D0 (sv) New compound
ZA934708B (en) Peptide compounds active in cell adhesion processes, a process for the preparation thereof, and pharmaceutical compositions containing them
KR970058721A (ko) 향균 및 항진균 활성을 갖는 펩타이드
ECSP951610A (es) Antagonistas de taquicinina