IL105400A - Production of recombinant human lactoferrin in fungal cells - Google Patents

Production of recombinant human lactoferrin in fungal cells

Info

Publication number
IL105400A
IL105400A IL10540093A IL10540093A IL105400A IL 105400 A IL105400 A IL 105400A IL 10540093 A IL10540093 A IL 10540093A IL 10540093 A IL10540093 A IL 10540093A IL 105400 A IL105400 A IL 105400A
Authority
IL
Israel
Prior art keywords
production
human lactoferrin
recombinant human
fungal cells
lactoferrin protein
Prior art date
Application number
IL10540093A
Other languages
English (en)
Other versions
IL105400A0 (en
Original Assignee
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Medicine filed Critical Baylor College Medicine
Publication of IL105400A0 publication Critical patent/IL105400A0/xx
Publication of IL105400A publication Critical patent/IL105400A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
IL10540093A 1992-04-24 1993-04-15 Production of recombinant human lactoferrin in fungal cells IL105400A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87330492A 1992-04-24 1992-04-24

Publications (2)

Publication Number Publication Date
IL105400A0 IL105400A0 (en) 1993-08-18
IL105400A true IL105400A (en) 2003-03-12

Family

ID=25361366

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10540093A IL105400A (en) 1992-04-24 1993-04-15 Production of recombinant human lactoferrin in fungal cells

Country Status (19)

Country Link
US (1) US5571896A (pt)
EP (1) EP0644899B1 (pt)
JP (1) JP2824332B2 (pt)
KR (2) KR0184693B1 (pt)
CN (2) CN1047204C (pt)
AT (1) ATE177473T1 (pt)
AU (1) AU681583B2 (pt)
BR (1) BR9306289A (pt)
CA (1) CA2134094C (pt)
DE (1) DE69323879T2 (pt)
DK (1) DK0644899T3 (pt)
ES (1) ES2132232T3 (pt)
GR (1) GR3029942T3 (pt)
HK (1) HK1027360A1 (pt)
IL (1) IL105400A (pt)
NZ (1) NZ252844A (pt)
SG (1) SG47605A1 (pt)
WO (1) WO1993022348A1 (pt)
ZA (1) ZA932568B (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5633076A (en) * 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US6066469A (en) * 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
JP3529423B2 (ja) * 1994-04-01 2004-05-24 森永乳業株式会社 抗菌性ペプチドの製造方法
FR2735983B1 (fr) 1995-06-29 1997-12-05 Centre Nat Rech Scient Peptide permettant de modifier l'activite du systeme immunitaire humain ou animal
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
JP2002515893A (ja) 1997-02-03 2002-05-28 ファーミング インテレクチュアル プロパティ ビーブイ ヒトラクトフェリンおよびその改変体の有用な特性
JP3681982B2 (ja) 1998-07-15 2005-08-10 サムヤン ジェネックス コーポレイション 酵母からラクトフェリンポリペプチドを大量生産する方法及びそれに有用な微生物菌株
AU4656999A (en) * 1998-07-15 2000-02-07 Samyang Genex Corporation Mass production method of lactoferrin polypeptide from yeast and useful microorganism thereof
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
AU7042000A (en) * 1999-10-19 2001-05-14 Easy Bio System, Inc. Recombinant yeast strain for expressing human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin and process for preparation recombinant human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin using the same
US7138150B2 (en) * 2000-05-02 2006-11-21 Ventria Bioscience Method of making an anti-infective composition for treating oral infections
US7417178B2 (en) * 2000-05-02 2008-08-26 Ventria Bioscience Expression of human milk proteins in transgenic plants
US20080050503A1 (en) * 2000-05-02 2008-02-28 Ning Huang Expression of human milk proteins in transgenic plants
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
AU2002323501C1 (en) * 2001-08-30 2010-04-29 Biorexis Technology, Inc Modified transferrin fusion proteins
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
US20070031440A1 (en) * 2001-08-30 2007-02-08 Prior Christopher P Modified transferin-antibody fusion proteins
WO2003057712A2 (en) * 2001-12-28 2003-07-17 Campina B.V. Humanized lactoferrin and uses thereof
JP4685443B2 (ja) * 2002-05-10 2011-05-18 エイジェニックス・インコーポレイテッド 悪性新生物および他の過剰増殖性疾患の治療におけるラクトフェリン
US7238661B2 (en) * 2002-05-24 2007-07-03 Agennix, Inc. Oral lactoferrin in the treatment of respiratory disorders
DE60333306D1 (de) * 2002-08-30 2010-08-19 Biorexis Pharmaceutical Corp Modifizierte transferrin-fusionsproteine mit doppelten transferrin-amino- oder carboxy-terminalen domänen
US20060105387A1 (en) * 2002-08-30 2006-05-18 Prior Christopher P Transferrin fusion proteins libraries
DK1545587T3 (da) * 2002-09-16 2011-05-09 Agennix Inc Lactoferrinsammensætninger og fremgangsmåder til behandling af diabetiske sår
AU2003298906A1 (en) * 2002-12-06 2004-06-30 Agennix Incorporated Oral lactoferrin in the treatment of sepsis
AU2003296447A1 (en) 2002-12-10 2004-06-30 Agennix Incorporated Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
US20070060512A1 (en) * 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
KR100468596B1 (ko) * 2003-04-04 2005-01-27 (주) 디지탈바이오텍 메탄올자화효모인 피치아 패스토리스를 이용하여 인간락토페린을 생산하는 방법, 이 방법에 의해 제조된 인간락토페린 및 피치아 패스토리스 균주
US7379700B2 (en) * 2003-05-06 2008-05-27 Canon Kabushiki Kaisha Image reading apparatus with rotatable internal and external guides
AU2004289170B2 (en) * 2003-06-06 2009-12-17 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
US20040259770A1 (en) * 2003-06-19 2004-12-23 Rush University Medical Center Method for determining leukocyte activation
US20050075277A1 (en) * 2003-07-10 2005-04-07 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
JP2007512001A (ja) * 2003-08-28 2007-05-17 バイオレクシス ファーマシューティカル コーポレイション Ｅｐｏミメティックペプチドおよび融合タンパク質
US20060205037A1 (en) * 2003-08-28 2006-09-14 Homayoun Sadeghi Modified transferrin fusion proteins
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
WO2005085287A1 (en) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
JP5631533B2 (ja) 2004-12-23 2014-11-26 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 遺伝子発現技術
CA2655331A1 (en) 2006-06-22 2007-12-27 Agennix Incorporated Lactoferrin as a radioprotective agent
DK2046826T3 (da) 2006-07-24 2011-10-24 Biorexis Pharmaceutical Corp Exendin-fusionsproteiner
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
AU2008274969B2 (en) 2007-07-10 2014-04-24 Glanbia Nutritionals Method for removing endotoxin from proteins
JP2013520475A (ja) 2010-02-25 2013-06-06 アゲンニックス・アーゲー 重症敗血症の治療における経口ラクトフェリン
EP2851421B1 (en) * 2012-07-03 2018-11-28 Kao Corporation Useful microorganism, and method for producing substance of interest
JP2022513594A (ja) * 2018-11-06 2022-02-09 アルヘル プロジェクティランジェ イン インゼニリング ディー．オー．オー． 乳、初乳及び酸性又は甘性ホエーから高度に精製されたラクトフェリン及びラクトペルオキシダーゼを製造する方法
KR200494603Y1 (ko) 2019-12-09 2021-11-12 한국청소년활동진흥원 타워형 구조를 이루는 기술 융합형 조립 교구

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
DK122686D0 (da) * 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
AU619458B2 (en) * 1987-01-30 1992-01-30 Board Of Trustees Of The Leland Stanford Junior University Lymphocyte inhibition by hla peptides
DE3886221T3 (de) * 1987-09-04 2000-12-21 Novo Nordisk As VERFAHREN ZUR HERSTELLUNG VON PROTEINPRODUKTEN IN -i(ASPERGILLUS) UND PROMOTOREN ZUR VERWENDUNG IN -i(ASPERGILLUS).
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5155037A (en) * 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
WO1991013982A1 (en) * 1990-03-08 1991-09-19 Ferrodynamics, Inc. Genetically engineered human lactoferrin
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤

Also Published As

Publication number Publication date
IL105400A0 (en) 1993-08-18
EP0644899B1 (en) 1999-03-10
CA2134094C (en) 2004-01-06
GR3029942T3 (en) 1999-07-30
EP0644899A1 (en) 1995-03-29
US5571896A (en) 1996-11-05
KR950701348A (ko) 1995-03-23
CN1250055A (zh) 2000-04-12
DE69323879D1 (de) 1999-04-15
AU4289293A (en) 1993-11-29
NZ252844A (en) 1996-05-28
DK0644899T3 (da) 1999-09-27
CN1161382C (zh) 2004-08-11
DE69323879T2 (de) 1999-11-04
WO1993022348A1 (en) 1993-11-11
SG47605A1 (en) 1998-04-17
CN1047204C (zh) 1999-12-08
ZA932568B (en) 1993-11-12
EP0644899A4 (en) 1996-06-26
BR9306289A (pt) 1998-06-30
JP2824332B2 (ja) 1998-11-11
JPH08504561A (ja) 1996-05-21
CA2134094A1 (en) 1993-11-11
AU681583B2 (en) 1997-09-04
ATE177473T1 (de) 1999-03-15
ES2132232T3 (es) 1999-08-16
KR0184693B1 (ko) 1999-04-01
CN1079780A (zh) 1993-12-22
HK1027360A1 (en) 2001-01-12
KR100221404B1 (en) 1999-10-01

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