IL104385A - Method and device for growing biomass particles - Google Patents
Method and device for growing biomass particlesInfo
- Publication number
- IL104385A IL104385A IL10438593A IL10438593A IL104385A IL 104385 A IL104385 A IL 104385A IL 10438593 A IL10438593 A IL 10438593A IL 10438593 A IL10438593 A IL 10438593A IL 104385 A IL104385 A IL 104385A
- Authority
- IL
- Israel
- Prior art keywords
- culture medium
- vessel
- hollow container
- top opening
- biomass particles
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims abstract description 56
- 239000002028 Biomass Substances 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 20
- 239000001963 growth medium Substances 0.000 claims abstract description 60
- 230000005484 gravity Effects 0.000 claims abstract description 9
- 238000004114 suspension culture Methods 0.000 claims abstract description 8
- 239000012530 fluid Substances 0.000 claims abstract description 6
- 238000013019 agitation Methods 0.000 claims description 12
- 210000004027 cell Anatomy 0.000 description 18
- 239000011324 bead Substances 0.000 description 9
- 230000012010 growth Effects 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/22—Settling tanks; Sedimentation by gravity
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82230192A | 1992-01-17 | 1992-01-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104385A0 IL104385A0 (en) | 1993-05-13 |
| IL104385A true IL104385A (en) | 1995-12-31 |
Family
ID=25235685
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10438593A IL104385A (en) | 1992-01-17 | 1993-01-13 | Method and device for growing biomass particles |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5654197A (de) |
| EP (1) | EP0585419B1 (de) |
| JP (1) | JP3244701B2 (de) |
| AT (1) | ATE197813T1 (de) |
| AU (1) | AU664596B2 (de) |
| CA (1) | CA2106064C (de) |
| DE (1) | DE69329706T2 (de) |
| DK (1) | DK0585419T3 (de) |
| ES (1) | ES2151901T3 (de) |
| GR (1) | GR3035408T3 (de) |
| IL (1) | IL104385A (de) |
| PT (1) | PT585419E (de) |
| WO (1) | WO1993014192A1 (de) |
| ZA (1) | ZA93310B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998184A (en) * | 1997-10-08 | 1999-12-07 | Unisyn Technologies, Inc. | Basket-type bioreactor |
| US6335191B1 (en) | 1998-02-27 | 2002-01-01 | Nch Corporation | Automated system and method for growing bacteria |
| DE19918409A1 (de) * | 1999-04-22 | 2000-10-26 | Forschungszentrum Juelich Gmbh | Bioreaktor umfassend einen Medienablauf und einen Rührer sowie Rührer und Medienablauf |
| US20040185535A1 (en) * | 2003-03-21 | 2004-09-23 | Giles Wilson | Industrial-scale serum-free production of recombinant FVII in mammalian cells |
| AU2001291652B2 (en) * | 2000-10-02 | 2007-09-13 | Novo Nordisk Health Care Ag | Factor VII glycoforms |
| US20040185534A1 (en) * | 2000-10-02 | 2004-09-23 | Knudsen Ida Molgaard | Industrial-scale serum-free production of recombinant proteins in mammalian cells |
| US20020179544A1 (en) * | 2001-04-27 | 2002-12-05 | Nexell Therapeutics, Inc. | Cell processing and fluid transfer apparatus and method of use |
| DE60221553T2 (de) * | 2001-10-02 | 2008-04-10 | Novo Nordisk Health Care Ag | Verfahren zur herstelllung rekombinanter proteine in eukaryontischen zellen |
| US7160719B2 (en) | 2002-06-07 | 2007-01-09 | Mayo Foundation For Medical Education And Research | Bioartificial liver system |
| CN1300297C (zh) * | 2002-09-20 | 2007-02-14 | 华东理工大学 | 一种用于动物细胞扩大接种的消化反应器 |
| US7081361B2 (en) * | 2003-08-07 | 2006-07-25 | Nch Corporation | Biomass generator |
| US20080020049A1 (en) * | 2005-02-25 | 2008-01-24 | Andrew Darling | Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications |
| CN102421467B (zh) * | 2009-03-13 | 2015-04-22 | 梅约医学教育与研究基金会 | 生物人工肝 |
| US8551762B2 (en) * | 2009-07-07 | 2013-10-08 | Nch Corporation | System and apparatus for feeding, solubilizing, growing and discharging a biological material |
| US8961893B2 (en) * | 2009-07-07 | 2015-02-24 | Nch Corporation | Automated chemical diluter system having disposable components |
| DE102009026366A1 (de) | 2009-08-12 | 2011-02-17 | Technische Universität München | Fermentationsbehälter sowie Verfahren und Vorrichtung zur Fermentation |
| JP5415330B2 (ja) * | 2010-03-12 | 2014-02-12 | 株式会社日立製作所 | 生体細胞の培養装置及び培養方法 |
| ES2890412T3 (es) * | 2011-01-17 | 2022-01-19 | Hoffmann La Roche | Aparato de separación |
| US20170096628A1 (en) * | 2014-04-14 | 2017-04-06 | Enevor Inc. | Conical Impeller and Applications Thereof |
| US20170218330A1 (en) * | 2016-02-01 | 2017-08-03 | Fenwal, Inc. | Systems and methods for the separation of cells from microcarriers using a spinning membrane |
| JP6744161B2 (ja) * | 2016-07-19 | 2020-08-19 | 株式会社日立プラントサービス | 分離装置、培養装置および分離方法 |
| CN114058505B (zh) | 2020-07-30 | 2024-10-01 | 环球生命科技咨询美国有限责任公司 | 新型灌流培养用高密度微载体截留装置和使用方法 |
| JP7524841B2 (ja) * | 2021-06-24 | 2024-07-30 | 横河電機株式会社 | 細胞培養プロセスに使用するための溶液処理デバイス |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR821326A (fr) * | 1936-05-04 | 1937-12-02 | Procédé et appareil pour la fermentation continue de solutions, en vue de l'obtention de produits de fermentation ou de micro-organismes qui se multiplient | |
| US2451156A (en) * | 1944-06-19 | 1948-10-12 | Mattos Annibal Ramos De | Process and apparatus for producing alcohol by fermentation |
| JPS575690A (en) * | 1980-06-13 | 1982-01-12 | Toray Ind Inc | Circulation device for culture medium in cultivation tank |
| US4335215A (en) * | 1980-08-27 | 1982-06-15 | Monsanto Company | Method of growing anchorage-dependent cells |
| CS231837B1 (en) * | 1982-07-30 | 1984-12-14 | Svatopluk Mackrle | Device for a biological water purification |
| JPS63123379A (ja) * | 1986-11-12 | 1988-05-27 | Teijin Ltd | 動物細胞の培養方法 |
| US4814278A (en) * | 1985-02-05 | 1989-03-21 | Teijin Limited | Culture apparatus and method |
| GB8515636D0 (en) * | 1985-06-20 | 1985-07-24 | Celltech Ltd | Fermenter |
| JPH0195769A (ja) * | 1987-10-08 | 1989-04-13 | Ebara Res Co Ltd | 高濃度培養装置 |
| JPH0380077A (ja) * | 1989-08-23 | 1991-04-04 | Meiji Milk Prod Co Ltd | マイクロキャリア分離方法及び装置 |
| CA2072141A1 (en) * | 1989-11-03 | 1991-05-04 | William G. Thilly | Nested-cone separator |
| JP3385741B2 (ja) * | 1994-08-22 | 2003-03-10 | 日本ゼオン株式会社 | 医用材料組成物、その調製方法及び医用成形物 |
-
1993
- 1993-01-13 IL IL10438593A patent/IL104385A/en not_active IP Right Cessation
- 1993-01-15 AT AT93903440T patent/ATE197813T1/de active
- 1993-01-15 JP JP51262993A patent/JP3244701B2/ja not_active Expired - Fee Related
- 1993-01-15 PT PT93903440T patent/PT585419E/pt unknown
- 1993-01-15 DK DK93903440T patent/DK0585419T3/da active
- 1993-01-15 CA CA002106064A patent/CA2106064C/en not_active Expired - Fee Related
- 1993-01-15 EP EP93903440A patent/EP0585419B1/de not_active Expired - Lifetime
- 1993-01-15 WO PCT/US1993/000272 patent/WO1993014192A1/en not_active Ceased
- 1993-01-15 AU AU34703/93A patent/AU664596B2/en not_active Ceased
- 1993-01-15 DE DE69329706T patent/DE69329706T2/de not_active Expired - Lifetime
- 1993-01-15 ES ES93903440T patent/ES2151901T3/es not_active Expired - Lifetime
- 1993-01-18 ZA ZA93310A patent/ZA93310B/xx unknown
- 1993-08-06 US US08/102,098 patent/US5654197A/en not_active Expired - Lifetime
-
2001
- 2001-02-14 GR GR20010400237T patent/GR3035408T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0585419A1 (de) | 1994-03-09 |
| PT585419E (pt) | 2001-04-30 |
| CA2106064A1 (en) | 1993-07-18 |
| ATE197813T1 (de) | 2000-12-15 |
| GR3035408T3 (en) | 2001-05-31 |
| AU664596B2 (en) | 1995-11-23 |
| DK0585419T3 (da) | 2001-03-19 |
| EP0585419A4 (de) | 1995-04-05 |
| JPH06510205A (ja) | 1994-11-17 |
| WO1993014192A1 (en) | 1993-07-22 |
| EP0585419B1 (de) | 2000-11-29 |
| DE69329706D1 (de) | 2001-01-04 |
| ES2151901T3 (es) | 2001-01-16 |
| JP3244701B2 (ja) | 2002-01-07 |
| CA2106064C (en) | 2005-09-20 |
| HK1012674A1 (en) | 1999-08-06 |
| DE69329706T2 (de) | 2001-03-29 |
| IL104385A0 (en) | 1993-05-13 |
| US5654197A (en) | 1997-08-05 |
| AU3470393A (en) | 1993-08-03 |
| ZA93310B (en) | 1993-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |