IL103603A - Proteins involved in the biosynthesis of an antibiotic polypeptide, a method for making the above proteins, and the DNA encoding them - Google Patents

Proteins involved in the biosynthesis of an antibiotic polypeptide, a method for making the above proteins, and the DNA encoding them

Info

Publication number
IL103603A
IL103603A IL10360392A IL10360392A IL103603A IL 103603 A IL103603 A IL 103603A IL 10360392 A IL10360392 A IL 10360392A IL 10360392 A IL10360392 A IL 10360392A IL 103603 A IL103603 A IL 103603A
Authority
IL
Israel
Prior art keywords
protein
epi
dna
sequence
host
Prior art date
Application number
IL10360392A
Other languages
English (en)
Hebrew (he)
Other versions
IL103603A0 (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL103603A0 publication Critical patent/IL103603A0/xx
Publication of IL103603A publication Critical patent/IL103603A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IL10360392A 1991-10-31 1992-10-30 Proteins involved in the biosynthesis of an antibiotic polypeptide, a method for making the above proteins, and the DNA encoding them IL103603A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78423491A 1991-10-31 1991-10-31

Publications (2)

Publication Number Publication Date
IL103603A0 IL103603A0 (en) 1993-03-15
IL103603A true IL103603A (en) 1999-12-31

Family

ID=25131778

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10360392A IL103603A (en) 1991-10-31 1992-10-30 Proteins involved in the biosynthesis of an antibiotic polypeptide, a method for making the above proteins, and the DNA encoding them

Country Status (18)

Country Link
EP (1) EP0543195B1 (cs)
JP (1) JP4117033B2 (cs)
KR (1) KR100242268B1 (cs)
AT (1) ATE162852T1 (cs)
AU (1) AU661054B2 (cs)
CA (1) CA2081704C (cs)
CZ (2) CZ286727B6 (cs)
DE (1) DE69224269T2 (cs)
DK (1) DK0543195T3 (cs)
ES (1) ES2112289T3 (cs)
FI (1) FI104498B (cs)
GR (1) GR3026465T3 (cs)
HU (1) HU215548B (cs)
IL (1) IL103603A (cs)
MX (1) MX9206265A (cs)
NO (1) NO307474B1 (cs)
NZ (1) NZ244976A (cs)
ZA (1) ZA928397B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662898A (en) * 1990-08-20 1997-09-02 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5639949A (en) * 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US6117670A (en) * 1994-06-08 2000-09-12 Novartis Finance Corporation Pyrrolnitrin biosynthesis genes and uses thereof
US5932469A (en) 1997-06-10 1999-08-03 University Of Florida Antimicrobial polypeptide, nucleic acid, and methods of use
US6475771B1 (en) 1997-06-10 2002-11-05 University Of Florida Research Foundation Antimicrobial polypeptides and methods of use
US6964760B2 (en) 1997-06-10 2005-11-15 University Of Florida Research Foundation Antimicrobial polypeptide, nucleic acid, and methods of use
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
DE10261782A1 (de) * 2002-12-19 2004-07-01 Dr. Petry Genmedics Gmbh Neue Gene und Genprodukte
WO2006062398A2 (en) * 2004-12-07 2006-06-15 Applied Nanosystems B.V. Methods for the production and secretion of modified peptides
CN115261274B (zh) * 2022-08-05 2023-11-21 天康制药股份有限公司 一种表皮葡萄球菌高密度发酵培养基及其发酵方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8811761D0 (en) * 1988-05-18 1988-06-22 Thomae Gmbh Dr K Biosynthetic process for preparation of chemical compounds

Also Published As

Publication number Publication date
FI104498B (fi) 2000-02-15
HU9203434D0 (en) 1993-01-28
EP0543195A2 (en) 1993-05-26
ES2112289T3 (es) 1998-04-01
DK0543195T3 (da) 1998-09-23
CZ326992A3 (en) 1993-09-15
NZ244976A (en) 1995-07-26
ZA928397B (en) 1994-05-02
DE69224269D1 (de) 1998-03-05
CZ359396A3 (cs) 1999-03-17
ATE162852T1 (de) 1998-02-15
EP0543195A3 (en) 1994-06-08
JP4117033B2 (ja) 2008-07-09
HUT65492A (en) 1994-06-28
CA2081704C (en) 2007-05-01
DE69224269T2 (de) 1998-06-04
AU2745992A (en) 1993-05-27
JPH05292952A (ja) 1993-11-09
EP0543195B1 (en) 1998-01-28
CA2081704A1 (en) 1993-05-01
NO307474B1 (no) 2000-04-10
KR100242268B1 (ko) 2000-02-01
NO924192L (no) 1993-05-03
KR930008147A (ko) 1993-05-21
NO924192D0 (no) 1992-10-30
FI924909A0 (fi) 1992-10-29
MX9206265A (es) 1994-05-31
FI924909A (fi) 1993-05-01
CZ284861B6 (cs) 1999-03-17
IL103603A0 (en) 1993-03-15
HU215548B (hu) 1999-01-28
CZ286727B6 (cs) 2000-06-14
GR3026465T3 (en) 1998-06-30
AU661054B2 (en) 1995-07-13

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Legal Events

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EXP Patent expired