IL102456A - Medicinal preparations containing a history of xanthine for the treatment of secondary damage to nerve cells and functional disorders of closed skull-brain injury, some such new compounds - Google Patents
Medicinal preparations containing a history of xanthine for the treatment of secondary damage to nerve cells and functional disorders of closed skull-brain injury, some such new compoundsInfo
- Publication number
- IL102456A IL102456A IL10245692A IL10245692A IL102456A IL 102456 A IL102456 A IL 102456A IL 10245692 A IL10245692 A IL 10245692A IL 10245692 A IL10245692 A IL 10245692A IL 102456 A IL102456 A IL 102456A
- Authority
- IL
- Israel
- Prior art keywords
- chain
- carbon atoms
- alkyl
- whose
- straight
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 206010019196 Head injury Diseases 0.000 title claims abstract description 23
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 11
- 150000001875 compounds Chemical class 0.000 title claims description 20
- 238000002360 preparation method Methods 0.000 title claims description 12
- 210000002569 neuron Anatomy 0.000 title description 4
- 230000005779 cell damage Effects 0.000 title description 2
- 208000037887 cell injury Diseases 0.000 title description 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 60
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 41
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 35
- 239000001257 hydrogen Substances 0.000 claims abstract description 18
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 18
- 125000005188 oxoalkyl group Chemical group 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims abstract description 13
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 12
- 208000035475 disorder Diseases 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract description 8
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 9
- -1 7-substituted xanthine Chemical class 0.000 claims description 8
- 125000000075 primary alcohol group Chemical group 0.000 claims description 7
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- 150000001350 alkyl halides Chemical class 0.000 claims description 6
- 125000006239 protecting group Chemical group 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 claims description 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- RBQOQRRFDPXAGN-UHFFFAOYSA-N Propentofylline Chemical compound CN1C(=O)N(CCCCC(C)=O)C(=O)C2=C1N=CN2CCC RBQOQRRFDPXAGN-UHFFFAOYSA-N 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
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- 150000002367 halogens Chemical group 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
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- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
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- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000019432 tissue death Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4122884 | 1991-07-11 | ||
| DE4217639 | 1992-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL102456A0 IL102456A0 (en) | 1993-01-14 |
| IL102456A true IL102456A (en) | 1996-10-16 |
Family
ID=25905369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10245692A IL102456A (en) | 1991-07-11 | 1992-07-09 | Medicinal preparations containing a history of xanthine for the treatment of secondary damage to nerve cells and functional disorders of closed skull-brain injury, some such new compounds |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5409935A (cs) |
| EP (1) | EP0528164B1 (cs) |
| JP (1) | JP3436547B2 (cs) |
| KR (1) | KR100237945B1 (cs) |
| AT (1) | ATE138573T1 (cs) |
| AU (1) | AU649851B2 (cs) |
| CA (1) | CA2073633C (cs) |
| CZ (2) | CZ282140B6 (cs) |
| DE (1) | DE59206403D1 (cs) |
| DK (1) | DK0528164T3 (cs) |
| ES (1) | ES2088519T3 (cs) |
| GR (1) | GR3020233T3 (cs) |
| HU (1) | HU217983B (cs) |
| IE (1) | IE74888B1 (cs) |
| IL (1) | IL102456A (cs) |
| MX (1) | MX9203323A (cs) |
| PH (1) | PH30341A (cs) |
| RU (1) | RU2126407C1 (cs) |
| SK (1) | SK280537B6 (cs) |
| TW (1) | TW210285B (cs) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580873A (en) * | 1992-03-04 | 1996-12-03 | Cell Therapeutics, Inc. | Enatiomerically pure hydroxylated xanthine compounds to treat proliferative vascular diseases |
| JP2753395B2 (ja) * | 1992-03-04 | 1998-05-20 | セル・セラピューティックス・インコーポレーテッド | 鏡像異性体ヒドロキシル化キサンチン化合物 |
| US5648357A (en) * | 1992-03-04 | 1997-07-15 | Cell Therapeutics, Inc. | Enatiomerically pure hydroxylated xanthine compounds |
| EP0570831A2 (de) * | 1992-05-20 | 1993-11-24 | Hoechst Aktiengesellschaft | Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation |
| AU1090795A (en) | 1993-11-12 | 1995-05-29 | Cell Therapeutics, Inc. | Method for preventing tissue injury from hypoxia |
| US5981536A (en) * | 1996-07-31 | 1999-11-09 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the modulation of apoptosis |
| US5856330A (en) * | 1996-07-31 | 1999-01-05 | Hoechst Aktiengesellschaft | Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin |
| US7115645B2 (en) | 2000-01-14 | 2006-10-03 | Schering Aktiengesellschaft | 1,2 diarylbenzimidazoles and their pharmaceutical use |
| WO2001051473A1 (de) * | 2000-01-14 | 2001-07-19 | Schering Aktiengesellschaft | 1,2-diarylbenzimidazole zur behandlung von krankungen die mit einer microglia-aktivierung assoziiert sind |
| US7329679B2 (en) | 2000-01-27 | 2008-02-12 | Schering Aktiengesellschaft | 1,2 Diarylbenzimidazoles and their pharmaceutical use |
| US20040110776A1 (en) * | 2002-02-22 | 2004-06-10 | Iok-Hou Pang | Use of propentofylline to control intraocular pressure |
| AU2003236702B2 (en) * | 2002-06-12 | 2007-03-08 | F. Hoffmann-La Roche Ag | Amide substituted xanthine derivatives with gluconeogenesis modulating activity |
| WO2005037286A1 (en) * | 2003-03-25 | 2005-04-28 | Vasopharm Biotech Gmbh | Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2330742C2 (de) * | 1973-06-16 | 1982-07-29 | Hoechst Ag, 6000 Frankfurt | 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| CH608236A5 (cs) * | 1974-01-22 | 1978-12-29 | Wuelfing J A Fa | |
| US4275064A (en) * | 1976-02-06 | 1981-06-23 | Interx Research Corporation | Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents |
| FR2531085A1 (fr) * | 1982-07-28 | 1984-02-03 | Adir | Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| IT1200944B (it) * | 1982-08-10 | 1989-01-27 | Malesci Sas | Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico |
| US4567183A (en) * | 1983-03-11 | 1986-01-28 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same |
| JPS6110715A (ja) * | 1984-06-26 | 1986-01-18 | Fanuc Ltd | 絶対位置検出方式 |
| JPH062675B2 (ja) * | 1985-04-05 | 1994-01-12 | ヘキストジヤパン株式会社 | 記憶障害治療剤 |
| DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| IT1197516B (it) * | 1986-12-24 | 1988-11-30 | Abc Ist Biolog Chem Spa | Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono |
| IT1229195B (it) * | 1989-03-10 | 1991-07-25 | Poli Ind Chimica Spa | Derivati xantinici ad attivita' broncodilatatrice e loro applicazioni terapeutiche. |
| GB8929208D0 (en) * | 1989-12-27 | 1990-02-28 | Almirall Lab | New xanthine derivatives |
-
1992
- 1992-06-25 MX MX9203323A patent/MX9203323A/es unknown
- 1992-07-09 US US07/909,389 patent/US5409935A/en not_active Expired - Lifetime
- 1992-07-09 IL IL10245692A patent/IL102456A/en not_active IP Right Cessation
- 1992-07-09 HU HU9202273A patent/HU217983B/hu unknown
- 1992-07-09 PH PH44627A patent/PH30341A/en unknown
- 1992-07-10 ES ES92111761T patent/ES2088519T3/es not_active Expired - Lifetime
- 1992-07-10 KR KR1019920012268A patent/KR100237945B1/ko not_active Expired - Lifetime
- 1992-07-10 DE DE59206403T patent/DE59206403D1/de not_active Expired - Lifetime
- 1992-07-10 EP EP92111761A patent/EP0528164B1/de not_active Expired - Lifetime
- 1992-07-10 DK DK92111761.0T patent/DK0528164T3/da active
- 1992-07-10 RU RU94027686/04A patent/RU2126407C1/ru active
- 1992-07-10 CZ CZ96816A patent/CZ282140B6/cs not_active IP Right Cessation
- 1992-07-10 AU AU19591/92A patent/AU649851B2/en not_active Expired
- 1992-07-10 IE IE922259A patent/IE74888B1/en not_active IP Right Cessation
- 1992-07-10 AT AT92111761T patent/ATE138573T1/de active
- 1992-07-10 CA CA002073633A patent/CA2073633C/en not_active Expired - Lifetime
- 1992-07-10 JP JP18328592A patent/JP3436547B2/ja not_active Expired - Lifetime
- 1992-07-10 CZ CS922160A patent/CZ281480B6/cs not_active IP Right Cessation
- 1992-07-10 SK SK2160-92A patent/SK280537B6/sk not_active IP Right Cessation
- 1992-07-25 TW TW081105886A patent/TW210285B/zh not_active IP Right Cessation
-
1996
- 1996-06-13 GR GR960401607T patent/GR3020233T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ81696A3 (en) | 1997-05-14 |
| TW210285B (cs) | 1993-08-01 |
| US5409935A (en) | 1995-04-25 |
| HUT61763A (en) | 1993-03-01 |
| AU649851B2 (en) | 1994-06-02 |
| ATE138573T1 (de) | 1996-06-15 |
| IL102456A0 (en) | 1993-01-14 |
| EP0528164B1 (de) | 1996-05-29 |
| HU217983B (hu) | 2000-05-28 |
| RU94027686A (ru) | 1996-05-27 |
| CZ216092A3 (en) | 1993-01-13 |
| AU1959192A (en) | 1993-01-14 |
| EP0528164A2 (de) | 1993-02-24 |
| CZ282140B6 (cs) | 1997-05-14 |
| DK0528164T3 (da) | 1996-09-30 |
| GR3020233T3 (en) | 1996-09-30 |
| IE922259A1 (en) | 1993-01-13 |
| HU9202273D0 (en) | 1992-10-28 |
| PH30341A (en) | 1997-04-02 |
| KR100237945B1 (ko) | 2000-02-01 |
| CA2073633C (en) | 2003-09-23 |
| DE59206403D1 (de) | 1996-07-04 |
| RU2126407C1 (ru) | 1999-02-20 |
| JP3436547B2 (ja) | 2003-08-11 |
| IE74888B1 (en) | 1997-08-13 |
| KR930001911A (ko) | 1993-02-22 |
| SK280537B6 (sk) | 2000-03-13 |
| MX9203323A (es) | 1994-07-29 |
| JPH05186350A (ja) | 1993-07-27 |
| EP0528164A3 (cs) | 1994-03-02 |
| ES2088519T3 (es) | 1996-08-16 |
| SK216092A3 (en) | 1995-09-13 |
| CZ281480B6 (cs) | 1996-10-16 |
| CA2073633A1 (en) | 1993-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| RH | Patent void | ||
| HP | Change in proprietorship | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |