PH30341A - Xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas - Google Patents

Xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas

Info

Publication number
PH30341A
PH30341A PH44627A PH44627A PH30341A PH 30341 A PH30341 A PH 30341A PH 44627 A PH44627 A PH 44627A PH 44627 A PH44627 A PH 44627A PH 30341 A PH30341 A PH 30341A
Authority
PH
Philippines
Prior art keywords
treatment
cranio
xanthine derivatives
nerve cell
cell damage
Prior art date
Application number
PH44627A
Other languages
English (en)
Inventor
Hans-Peter Schubert
John J Grome
Barbara Kittner
Karl Rudolphi
Ulrich Gebert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PH30341A publication Critical patent/PH30341A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PH44627A 1991-07-11 1992-07-09 Xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas PH30341A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4122884 1991-07-11
DE4217639 1992-05-28

Publications (1)

Publication Number Publication Date
PH30341A true PH30341A (en) 1997-04-02

Family

ID=25905369

Family Applications (1)

Application Number Title Priority Date Filing Date
PH44627A PH30341A (en) 1991-07-11 1992-07-09 Xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas

Country Status (20)

Country Link
US (1) US5409935A (cs)
EP (1) EP0528164B1 (cs)
JP (1) JP3436547B2 (cs)
KR (1) KR100237945B1 (cs)
AT (1) ATE138573T1 (cs)
AU (1) AU649851B2 (cs)
CA (1) CA2073633C (cs)
CZ (2) CZ81696A3 (cs)
DE (1) DE59206403D1 (cs)
DK (1) DK0528164T3 (cs)
ES (1) ES2088519T3 (cs)
GR (1) GR3020233T3 (cs)
HU (1) HU217983B (cs)
IE (1) IE74888B1 (cs)
IL (1) IL102456A (cs)
MX (1) MX9203323A (cs)
PH (1) PH30341A (cs)
RU (1) RU2126407C1 (cs)
SK (1) SK280537B6 (cs)
TW (1) TW210285B (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648357A (en) * 1992-03-04 1997-07-15 Cell Therapeutics, Inc. Enatiomerically pure hydroxylated xanthine compounds
ES2191013T3 (es) * 1992-03-04 2003-09-01 Cell Therapeutics Inc Compuestos de xantina enantiomeros hidroxilados.
US5567704A (en) * 1992-03-04 1996-10-22 Cell Therapeutics, Inc. R-enatiomerically pure hydroxylated xanthine compounds to treat baldness
EP0570831A2 (de) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation
WO1995013075A1 (en) 1993-11-12 1995-05-18 Cell Therapeutics, Inc. Method for preventing tissue injury from hypoxia
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
EP1246808B1 (de) * 2000-01-14 2011-08-17 Bayer Schering Pharma Aktiengesellschaft 1,2-diarylbenzimidazole zur behandlung von erkrankungen die mit einer microglia-aktivierung assoziiert sind
US7115645B2 (en) 2000-01-14 2006-10-03 Schering Aktiengesellschaft 1,2 diarylbenzimidazoles and their pharmaceutical use
US7329679B2 (en) 2000-01-27 2008-02-12 Schering Aktiengesellschaft 1,2 Diarylbenzimidazoles and their pharmaceutical use
US20040110776A1 (en) * 2002-02-22 2004-06-10 Iok-Hou Pang Use of propentofylline to control intraocular pressure
WO2005037286A1 (en) 2003-03-25 2005-04-28 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure and secondary ischemia

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2330742C2 (de) * 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
CH608236A5 (cs) * 1974-01-22 1978-12-29 Wuelfing J A Fa
US4275064A (en) * 1976-02-06 1981-06-23 Interx Research Corporation Transient pro-drug forms of xanthine derivatives and their use as topical anti-inflammatory agents
US4567183A (en) * 1983-03-11 1986-01-28 Analgesic Associates Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
JPS6110715A (ja) * 1984-06-26 1986-01-18 Fanuc Ltd 絶対位置検出方式
JPH062675B2 (ja) * 1985-04-05 1994-01-12 ヘキストジヤパン株式会社 記憶障害治療剤
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
IT1197516B (it) * 1986-12-24 1988-11-30 Abc Ist Biolog Chem Spa Derivati teofillinmetilanici e teofillinmetilditianici procedimento per la loro preparazione e composizioni farmaceutiche che li comprendono

Also Published As

Publication number Publication date
EP0528164B1 (de) 1996-05-29
CZ216092A3 (en) 1993-01-13
CZ281480B6 (cs) 1996-10-16
JP3436547B2 (ja) 2003-08-11
HU217983B (hu) 2000-05-28
TW210285B (cs) 1993-08-01
ES2088519T3 (es) 1996-08-16
KR100237945B1 (ko) 2000-02-01
JPH05186350A (ja) 1993-07-27
SK280537B6 (sk) 2000-03-13
IL102456A (en) 1996-10-16
DK0528164T3 (da) 1996-09-30
RU2126407C1 (ru) 1999-02-20
AU649851B2 (en) 1994-06-02
GR3020233T3 (en) 1996-09-30
CA2073633A1 (en) 1993-01-12
CZ282140B6 (cs) 1997-05-14
EP0528164A2 (de) 1993-02-24
ATE138573T1 (de) 1996-06-15
US5409935A (en) 1995-04-25
SK216092A3 (en) 1995-09-13
EP0528164A3 (cs) 1994-03-02
IE74888B1 (en) 1997-08-13
CA2073633C (en) 2003-09-23
HU9202273D0 (en) 1992-10-28
AU1959192A (en) 1993-01-14
IE922259A1 (en) 1993-01-13
CZ81696A3 (en) 1997-05-14
MX9203323A (es) 1994-07-29
DE59206403D1 (de) 1996-07-04
IL102456A0 (en) 1993-01-14
KR930001911A (ko) 1993-02-22
HUT61763A (en) 1993-03-01
RU94027686A (ru) 1996-05-27

Similar Documents

Publication Publication Date Title
ES2000823A6 (es) Metodo para la produccion de compuestos analogos a la vitamina d
ES486349A1 (es) Procedimiento para la preparacion de 5-(2-imidazolin-2-il)- aminopirimidinas
EP0430045A3 (en) Ascorbic acid tocopheryl phosphate diesters for inhibition of maillard's reaction
IL102456A0 (en) The use of xanthine derivatives for the treatment of secondary nerve cell damage and functional disorders after cranio-cerebral traumas
AU6786290A (en) Therapeutic application of fluoroquinolone derivatives for pneumocystosis
ES8407066A1 (es) Derivados de 6 -metilprednisolona.
ES8500942A1 (es) Un metodo para preparar nuevos derivados de guanina
ATE15370T1 (de) 3-piperidinyl-indole derivate, ihre salze, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende arzneimittel.
IL104026A0 (en) Pharmaceutical composition for the improvement of dysuria comprising xanthine derivatives
DE3274105D1 (en) Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene, their preparation and their therapeutic use
ZA867121B (en) Pyrido(1,2-a)pyrimidine derivatives,processes for preparing the same and pharmaceutical compositions for the treatment of allergic diseases containing the same
AU544275B2 (en) Triazololozuinazolinone derivatives
EP0242230A3 (en) Pyrido û1,2-a¨ pyrimidine derivatives
GR3001965T3 (en) Salts of 6-piperidino-2,4-diaminopyrimidin-3-oxide and of derivatives of thiamorpholin-3-on-5-carboxylic acid, their cosmetical and medicinal use
ES480765A1 (es) Procedimiento para la obtencion de 2-guanidinometil-indoli- nas.
SG4595G (en) Use of 2-oxo-imidazolidine derivatives in the prophylaxis and treatment of heart failure
GR3006582T3 (cs)