ES8500942A1 - Un metodo para preparar nuevos derivados de guanina - Google Patents

Un metodo para preparar nuevos derivados de guanina

Info

Publication number
ES8500942A1
ES8500942A1 ES523425A ES523425A ES8500942A1 ES 8500942 A1 ES8500942 A1 ES 8500942A1 ES 523425 A ES523425 A ES 523425A ES 523425 A ES523425 A ES 523425A ES 8500942 A1 ES8500942 A1 ES 8500942A1
Authority
ES
Spain
Prior art keywords
methoxy
fluoro
hydrogen
methylthio
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523425A
Other languages
English (en)
Other versions
ES523425A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Lakemedel AB
Original Assignee
Astra Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Lakemedel AB filed Critical Astra Lakemedel AB
Publication of ES8500942A1 publication Critical patent/ES8500942A1/es
Publication of ES523425A0 publication Critical patent/ES523425A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO PARA PREPARAR NUEVOS DERIVADOS DE GUANINA.CONSISTE EN CONDENSAR UNA CADENA LATERAL ACICLICA DE FORMULA (II) A LA POSICION N-9 DE UN DERIVADO DE GUANINA DE FORMULA (III), SEGUIDOS POR LA SEPARACION DE POSIBLES GRUPOS PROTECTORES PARA OBTENER DERIVADOS DE GUANINA DE FORMULA (I), LLEVANDOSE A CABO LA CONDENSACION EN PRESENCIA DE UN DISOLVENTE ORGANICO, TAL COMO DIMETIL-FORMAMIDA, ETANOL U OTROS, A TEMPERATURA ENTRE 0 Y 100JC DURANTE UNA HORA A TRES DIAS Y EN PRESENCIA DE UNA BASE TAL COMO CARBONATO DE POTASIO, DONDE R1 ES H, R2 E H, FLUORO, METOXI O METILTIO; R3 ES H, HIDROXI O MERCAPTO; X ES CLORO, BROMO Y OTROS; Y ES H O UN ION AMONIO CUATERNARIO. R5 ES R3, O OR6 O SR6; R6 ES H O UN GRUPO PROTECTOR DE HIDROXILO; R7 ES HIDROXILO, CLORO Y OTROS; R8 Y R9 SON HIDROGENO O UN GRUPO PROTECTOR DE AMINO.
ES523425A 1982-06-21 1983-06-20 Un metodo para preparar nuevos derivados de guanina Granted ES523425A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8203855A SE8203855D0 (sv) 1982-06-21 1982-06-21 Novel derivatives of guanine i

Publications (2)

Publication Number Publication Date
ES8500942A1 true ES8500942A1 (es) 1984-11-01
ES523425A0 ES523425A0 (es) 1984-11-01

Family

ID=20347137

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523425A Granted ES523425A0 (es) 1982-06-21 1983-06-20 Un metodo para preparar nuevos derivados de guanina

Country Status (17)

Country Link
EP (2) EP0112353A1 (es)
JP (1) JPS59501112A (es)
KR (1) KR840005141A (es)
AT (1) ATE18225T1 (es)
AU (1) AU1706083A (es)
DD (1) DD210274A5 (es)
DE (1) DE3362283D1 (es)
ES (1) ES523425A0 (es)
GB (1) GB2122198B (es)
GR (1) GR78621B (es)
IS (1) IS2822A7 (es)
NZ (1) NZ204640A (es)
PH (1) PH19399A (es)
PT (1) PT76902B (es)
SE (1) SE8203855D0 (es)
WO (1) WO1984000167A1 (es)
ZA (1) ZA834532B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
DE3571810D1 (en) * 1984-01-26 1989-08-31 Merck & Co Inc Substituted butyl guanines and their utilization in antiviral compositions
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
PT83201A (en) * 1985-08-16 1986-09-01 Glaxo Group Ltd Guanine derivatives
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3604899A1 (de) * 1986-02-17 1987-08-20 Hoechst Ag Chirale umsetzungsprodukte aus mesogenen molekuelbausteinen und bifunktionell reaktionsfaehigen butantetraolderivaten und ihre verwendung als dotierstoff in fluessigkristall-phasen
JPH01501478A (ja) * 1986-11-25 1989-05-25 インスティテュト　オルガニチェスコゴ　シンテザ　アカデミイ　ナウク　ラトビイスコイ　エスエスアール ９―置換グアニン
US4973318A (en) * 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
EP1990409A3 (en) 1999-07-20 2011-05-18 MorphoSys AG Bacteriophage

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4230708A (en) * 1977-10-20 1980-10-28 Stichting Rega V.Z.W. Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use

Also Published As

Publication number Publication date
KR840005141A (ko) 1984-11-03
PT76902B (en) 1986-04-09
AU1706083A (en) 1984-01-26
NZ204640A (en) 1986-07-11
ZA834532B (en) 1984-03-28
GR78621B (es) 1984-09-27
SE8203855D0 (sv) 1982-06-21
EP0112353A1 (en) 1984-07-04
EP0103551A2 (en) 1984-03-21
JPS59501112A (ja) 1984-06-28
EP0103551B1 (en) 1986-02-26
PH19399A (en) 1986-04-10
ATE18225T1 (de) 1986-03-15
GB2122198B (en) 1985-11-06
DD210274A5 (de) 1984-06-06
DE3362283D1 (en) 1986-04-03
GB8316743D0 (en) 1983-07-20
WO1984000167A1 (en) 1984-01-19
GB2122198A (en) 1984-01-11
ES523425A0 (es) 1984-11-01
PT76902A (en) 1983-07-01
EP0103551A3 (en) 1984-06-13
IS2822A7 (is) 1986-02-28

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