ZA834532B - Novel derivatives of guanine i - Google Patents

Novel derivatives of guanine i

Info

Publication number
ZA834532B
ZA834532B ZA834532A ZA834532A ZA834532B ZA 834532 B ZA834532 B ZA 834532B ZA 834532 A ZA834532 A ZA 834532A ZA 834532 A ZA834532 A ZA 834532A ZA 834532 B ZA834532 B ZA 834532B
Authority
ZA
South Africa
Prior art keywords
methoxy
fluoro
hydrogen
methylthio
compounds
Prior art date
Application number
ZA834532A
Other languages
English (en)
Inventor
Karin Ingeborg Eklind
Karl Nils Gunnar Johansson
Kristina Birgitta Gotthammar
Zsuzsanna Maria Ilona Kovacs
Curt Erik Hagberg
Jan Olof Noren
Goran Bertil Stening
Original Assignee
Astra Laekemedel Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab
Publication of ZA834532B publication Critical patent/ZA834532B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/03Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04Saturated ethers
    • C07C43/13Saturated ethers containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16Radicals substituted by halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA834532A 1982-06-21 1983-06-21 Novel derivatives of guanine i ZA834532B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8203855A SE8203855D0 (sv) 1982-06-21 1982-06-21 Novel derivatives of guanine i

Publications (1)

Publication Number Publication Date
ZA834532B true ZA834532B (en) 1984-03-28

Family

ID=20347137

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA834532A ZA834532B (en) 1982-06-21 1983-06-21 Novel derivatives of guanine i

Country Status (17)

Country Link
EP (2) EP0112353A1 (xx)
JP (1) JPS59501112A (xx)
KR (1) KR840005141A (xx)
AT (1) ATE18225T1 (xx)
AU (1) AU1706083A (xx)
DD (1) DD210274A5 (xx)
DE (1) DE3362283D1 (xx)
ES (1) ES523425A0 (xx)
GB (1) GB2122198B (xx)
GR (1) GR78621B (xx)
IS (1) IS2822A7 (xx)
NZ (1) NZ204640A (xx)
PH (1) PH19399A (xx)
PT (1) PT76902B (xx)
SE (1) SE8203855D0 (xx)
WO (1) WO1984000167A1 (xx)
ZA (1) ZA834532B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
EP0152316B1 (en) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituted butyl guanines and their utilization in antiviral compositions
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
GR862141B (en) * 1985-08-16 1986-12-23 Glaxo Group Ltd Guanine derivatives
DE3627024A1 (de) 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3604899A1 (de) * 1986-02-17 1987-08-20 Hoechst Ag Chirale umsetzungsprodukte aus mesogenen molekuelbausteinen und bifunktionell reaktionsfaehigen butantetraolderivaten und ihre verwendung als dotierstoff in fluessigkristall-phasen
EP0290630A4 (de) * 1986-11-25 1990-02-26 Inst Organicheskogo Sinteza Ak 9-substituierte guanine.
US4973318A (en) * 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
US5216141A (en) * 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
ATE417925T1 (de) 1999-07-20 2009-01-15 Morphosys Ag Verfahren zur präsentation von (poly)peptiden/proteinen auf bakteriophagenpartikeln via disulfidbindungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4230708A (en) * 1977-10-20 1980-10-28 Stichting Rega V.Z.W. Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
IL64501A (en) * 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use

Also Published As

Publication number Publication date
EP0103551A2 (en) 1984-03-21
GR78621B (xx) 1984-09-27
GB8316743D0 (en) 1983-07-20
AU1706083A (en) 1984-01-26
EP0103551A3 (en) 1984-06-13
ES8500942A1 (es) 1984-11-01
KR840005141A (ko) 1984-11-03
PT76902B (en) 1986-04-09
GB2122198B (en) 1985-11-06
IS2822A7 (is) 1986-02-28
JPS59501112A (ja) 1984-06-28
PH19399A (en) 1986-04-10
ATE18225T1 (de) 1986-03-15
NZ204640A (en) 1986-07-11
WO1984000167A1 (en) 1984-01-19
EP0112353A1 (en) 1984-07-04
SE8203855D0 (sv) 1982-06-21
DE3362283D1 (en) 1986-04-03
EP0103551B1 (en) 1986-02-26
DD210274A5 (de) 1984-06-06
GB2122198A (en) 1984-01-11
ES523425A0 (es) 1984-11-01
PT76902A (en) 1983-07-01

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