IL101033A - 2,5-Disubstituted-1.2.4-triazolo [1,5a]pyrimidine derivatives their preparation and pharmaceutical compositions containing them - Google Patents

2,5-Disubstituted-1.2.4-triazolo [1,5a]pyrimidine derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number
IL101033A
IL101033A IL10103392A IL10103392A IL101033A IL 101033 A IL101033 A IL 101033A IL 10103392 A IL10103392 A IL 10103392A IL 10103392 A IL10103392 A IL 10103392A IL 101033 A IL101033 A IL 101033A
Authority
IL
Israel
Prior art keywords
triazolo
alkyl
group
amino
mole
Prior art date
Application number
IL10103392A
Other languages
English (en)
Other versions
IL101033A0 (en
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of IL101033A0 publication Critical patent/IL101033A0/xx
Publication of IL101033A publication Critical patent/IL101033A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL10103392A 1991-02-22 1992-02-21 2,5-Disubstituted-1.2.4-triazolo [1,5a]pyrimidine derivatives their preparation and pharmaceutical compositions containing them IL101033A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU91587A HU208693B (en) 1991-02-22 1991-02-22 Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them

Publications (2)

Publication Number Publication Date
IL101033A0 IL101033A0 (en) 1992-11-15
IL101033A true IL101033A (en) 1996-07-23

Family

ID=10950293

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10103392A IL101033A (en) 1991-02-22 1992-02-21 2,5-Disubstituted-1.2.4-triazolo [1,5a]pyrimidine derivatives their preparation and pharmaceutical compositions containing them

Country Status (19)

Country Link
EP (1) EP0500136B1 (de)
JP (1) JPH05148267A (de)
KR (1) KR920016456A (de)
CN (1) CN1033585C (de)
AT (1) ATE138067T1 (de)
AU (1) AU642073B2 (de)
CA (1) CA2061629A1 (de)
CS (1) CS51592A3 (de)
DE (1) DE69210647T2 (de)
ES (1) ES2089258T3 (de)
FI (1) FI100401B (de)
GB (1) GB2254611B (de)
HU (1) HU208693B (de)
IL (1) IL101033A (de)
PL (1) PL170050B1 (de)
RU (1) RU2097382C1 (de)
TW (1) TW213462B (de)
YU (1) YU17592A (de)
ZA (1) ZA921269B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (de) * 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
TW258648B (de) * 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
EP0628559B1 (de) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidinverbindungen und ihre Verwendung als Pharmazeutika
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
US8508469B1 (en) 1995-12-01 2013-08-13 Immersion Corporation Networked applications including haptic feedback
US6448253B1 (en) * 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
WO2003030904A1 (en) * 2001-10-08 2003-04-17 F. Hoffmann-La Roche Ag 8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide
CA2542290A1 (en) * 2003-10-17 2005-04-28 Nippon Kayaku Kabushiki Kaisha Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof
RU2378278C2 (ru) * 2008-01-24 2010-01-10 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 3-СУЛЬФОНИЛ-[1,2,3]ТРИАЗОЛО[1,5-a]ПИРИМИДИНЫ-АНТАГОНИСТЫ СЕРОТОНИНОВЫХ 5-HT6 РЕЦЕПТОРОВ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ
CA2775354C (en) 2009-09-29 2019-01-15 Margaret Phillips Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase
MA50375A (fr) * 2014-04-23 2021-05-26 Dart Neuroscience Cayman Ltd Compositions contenant des composés substitués de [1,2,4]triazolo[1,5-a]pyrimidine-7-yl utilisés en tant qu'inhibiteurs pde2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1792811C2 (de) * 1966-10-03 1982-12-30 VEB Deutsches Hydrierwerk Rodleben, DDR 4530 Roßlau "Arzneimittel mit koronargefäßerweiternder Wirkung"
DE2327133A1 (de) * 1972-06-07 1974-01-03 Icn Pharmaceuticals 2-subst.-thio-s-triazolo eckige klammer auf 1,5a eckige klammer zu -pyrimidine
US4497814A (en) * 1982-08-16 1985-02-05 Schering Corporation 2-(Pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives useful in increasing cardiac contractility
DD280111A1 (de) * 1986-01-09 1990-06-27 Hydrierwerk Rodleben Veb Verfahren zur herstellung neuer triazolo-pyrimidine

Also Published As

Publication number Publication date
YU17592A (sh) 1995-03-27
GB2254611A (en) 1992-10-14
AU1117592A (en) 1992-08-27
PL293564A1 (en) 1992-11-02
FI920776A0 (fi) 1992-02-21
FI920776A7 (fi) 1992-08-23
KR920016456A (ko) 1992-09-24
PL170050B1 (pl) 1996-10-31
CS51592A3 (en) 1992-10-14
ES2089258T3 (es) 1996-10-01
CN1033585C (zh) 1996-12-18
HU208693B (en) 1993-12-28
ATE138067T1 (de) 1996-06-15
CN1064277A (zh) 1992-09-09
FI100401B (fi) 1997-11-28
ZA921269B (en) 1993-08-26
HU910587D0 (en) 1991-09-30
GB2254611B (en) 1995-04-26
DE69210647T2 (de) 1997-01-09
IL101033A0 (en) 1992-11-15
EP0500136B1 (de) 1996-05-15
DE69210647D1 (de) 1996-06-20
HUT61308A (en) 1992-12-28
EP0500136A1 (de) 1992-08-26
RU2097382C1 (ru) 1997-11-27
TW213462B (de) 1993-09-21
AU642073B2 (en) 1993-10-07
GB9203736D0 (en) 1992-04-08
CA2061629A1 (en) 1992-08-23
JPH05148267A (ja) 1993-06-15

Similar Documents

Publication Publication Date Title
CA2667487C (en) Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
CA2251453C (en) 5-arylalkyl-substituted pyrazolo(4,3-d)pyrimidine-7-ones
US6200980B1 (en) Method of treating a patient having precancerous lesions with phenyl purinone derivatives
EP1768984B1 (de) Als aurora-kinase-inhibitoren nutzbare thienopyrimidine
AU2002321669B8 (en) Novel 2H-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient
US20060079536A1 (en) Calcium receptor modulating compound and use thereof
IL101033A (en) 2,5-Disubstituted-1.2.4-triazolo [1,5a]pyrimidine derivatives their preparation and pharmaceutical compositions containing them
JP2012514044A (ja) Ｒａｆキナーゼ阻害剤として有用なヘテロアリール化合物
HUT71818A (en) Pyrrolo-pyrimidine derivatives, process for preparing them and pharmaceutical compositions containing them
EP0091241A2 (de) Kondensierte Pyrrolinon-Derivate, und ihre Herstellung
MX2010013190A (es) Fenilimidazopirazinas novedosas.
FI80454B (fi) Foerfarande foer framstaellning av farmakologiskt vaerdefulla 2-piperazino-pteridiner.
KR960000358B1 (ko) 트리아졸로피리딘 또는 트리아졸로퀴놀린의 신규 아미노알킬티오 유도체, 그의 제조방법 및 특히 진통제로서 유용한 그것이 존재하는 약제.
CS258483B2 (en) Method of new thienopyridones production
PL119520B1 (en) Process for preparing novel,condensed pyrimidine derivatives pirimidina
FI68835C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 4-minoacyl-1,4,9,10-tetrahydropyrazolo(4,3-b)(1,5)bensodiaz epn-10-oner
US5478825A (en) 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
DK157872B (da) Analogifremgangsmaade til fremstilling af substituerede thienobenzodiazepinoner samt mellemprodukter til anvendelse ved denne fremgangsmaade
CS200169B2 (en) Method of producing novel imidazo/4,5-b/pyridines
HUT71352A (en) Heterocyclic derivatives
US4696928A (en) Substituted dihydroimidazo[1,2-a]quinoxalines
EP0121341B1 (de) Durch stickstoffhaltige heterocyclische Ringe substituierte Triazolo[4,3-c]pyrimidine und Triazolo[1,5-c]pyrimidine
CA1153375A (en) Anti-psychotic agents
NZ194228A (en) 2-(1,4-diazacycloalk-1-yl)-4-(morpholino or thiomorpholino)-8-substituted pyrimido(4,5-b)pyrimidines
US3912737A (en) Isoxazolopyridine carboxylic acids and esters

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees