IE63038B1 - Hydroxy-1,2,3,4-tetrahydroaminoacridines a process for their preparation and their use as medicaments - Google Patents

Hydroxy-1,2,3,4-tetrahydroaminoacridines a process for their preparation and their use as medicaments

Info

Publication number
IE63038B1
IE63038B1 IE365989A IE365989A IE63038B1 IE 63038 B1 IE63038 B1 IE 63038B1 IE 365989 A IE365989 A IE 365989A IE 365989 A IE365989 A IE 365989A IE 63038 B1 IE63038 B1 IE 63038B1
Authority
IE
Ireland
Prior art keywords
compound
formula
hydrogen
alkyl
pharmaceutically acceptable
Prior art date
Application number
IE365989A
Other languages
English (en)
Other versions
IE893659L (en
Inventor
Gregory M Shutske
Iv John D Tomer
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of IE893659L publication Critical patent/IE893659L/xx
Publication of IE63038B1 publication Critical patent/IE63038B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
IE365989A 1988-11-16 1989-11-15 Hydroxy-1,2,3,4-tetrahydroaminoacridines a process for their preparation and their use as medicaments IE63038B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27178888A 1988-11-16 1988-11-16

Publications (2)

Publication Number Publication Date
IE893659L IE893659L (en) 1990-05-16
IE63038B1 true IE63038B1 (en) 1995-03-22

Family

ID=23037088

Family Applications (1)

Application Number Title Priority Date Filing Date
IE365989A IE63038B1 (en) 1988-11-16 1989-11-15 Hydroxy-1,2,3,4-tetrahydroaminoacridines a process for their preparation and their use as medicaments

Country Status (15)

Country Link
EP (1) EP0369388B1 (fi)
KR (1) KR0156241B1 (fi)
AT (1) ATE89553T1 (fi)
CA (1) CA2003023C (fi)
DE (1) DE68906647T2 (fi)
DK (1) DK168290B1 (fi)
ES (1) ES2054987T3 (fi)
FI (1) FI90417C (fi)
HU (2) HU208674B (fi)
IE (1) IE63038B1 (fi)
IL (1) IL92307A0 (fi)
NO (1) NO894547L (fi)
NZ (1) NZ231376A (fi)
PT (1) PT92319B (fi)
ZA (1) ZA898720B (fi)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200462B (fi) * 1990-09-27 1993-02-21 Hoechst Roussel Pharma
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
WO2019207604A1 (en) * 2018-04-25 2019-10-31 Rajiv Gandhi Centre For Biotechnology Tacrine derivatives targeting nmda receptor, acetylcholine esterase, butyryl choline and beta secretase activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
EP0282959A3 (en) * 1987-03-17 1989-05-31 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 9-amino-tetrahydro-acridines and related compounds, a process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
ZA898720B (en) 1990-08-29
DE68906647D1 (de) 1993-06-24
NZ231376A (en) 1992-05-26
DK571989D0 (da) 1989-11-15
FI90417B (fi) 1993-10-29
HUT53087A (en) 1990-09-28
EP0369388A1 (en) 1990-05-23
ES2054987T3 (es) 1994-08-16
DE68906647T2 (de) 1993-10-07
ATE89553T1 (de) 1993-06-15
NO894547L (no) 1990-05-18
PT92319A (pt) 1990-05-31
CA2003023A1 (en) 1990-05-16
FI895416A0 (fi) 1989-11-14
HU211701A9 (en) 1995-12-28
KR900007809A (ko) 1990-06-02
DK168290B1 (da) 1994-03-07
DK571989A (da) 1990-05-17
HU208674B (en) 1993-12-28
HU895931D0 (en) 1990-02-28
NO894547D0 (no) 1989-11-15
KR0156241B1 (ko) 1998-11-16
EP0369388B1 (en) 1993-05-19
IL92307A0 (en) 1990-07-26
FI90417C (fi) 1994-02-10
IE893659L (en) 1990-05-16
PT92319B (pt) 1995-08-09
CA2003023C (en) 2001-05-29

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Legal Events

Date Code Title Description
MM4A Patent lapsed