ES2054987T3 - Hidroxi-1,2,3,4-tetrahidroaminoacridinas, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents

Hidroxi-1,2,3,4-tetrahidroaminoacridinas, un procedimiento para su preparacion y su uso como medicamentos.

Info

Publication number
ES2054987T3
ES2054987T3 ES89121037T ES89121037T ES2054987T3 ES 2054987 T3 ES2054987 T3 ES 2054987T3 ES 89121037 T ES89121037 T ES 89121037T ES 89121037 T ES89121037 T ES 89121037T ES 2054987 T3 ES2054987 T3 ES 2054987T3
Authority
ES
Spain
Prior art keywords
hydroxy
loweralkyl
preparation
hydrogen
tetrahydroaminoacridines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89121037T
Other languages
English (en)
Inventor
Gregory Michael Shutske
John Dick Tomer Iv
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2054987T3 publication Critical patent/ES2054987T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)

Abstract

AQUI SE DESCUBREN COMPUESTOS TENIENDO LA FORMULA I DONDE N ES 1 O 2; X ES HIDROGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR, HALOGENO, HIDROXILO, NITROGENO O TRIFLUOROMETILO; R ES HIDROGENO, BENCILO O ALCANOIL DE 2 A 12 ATOMOS DE CARBONO, CON LA PROVISION DE QUE EL GRUPO -OR NO PUEDE ESTAR SOBRE LA POSICION 1 DEL SISTEMA DE TRES ANILLOS; Y R1 Y R2 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR, ARILO ALQUILO INFERIOR, PERO AMBOS NO PUEDEN SER SIMULTANEAMENTE ARILO ALQUILO INFERIOR, O ALTERNATIVAMENTE R1 Y R2 TOMADAS JUNTAS PUEDEN CONSTITUIR EL GRUPO NR3R4 DONDE R3 Y R4 SON CADA UNO INDEPENDIENTEMENTE ALQUILO INFERIOR; Y UN PROCESO PARA SU PREPARACION. LOS COMPUESTOS PUEDEN SER USADOS PARA EL TRATAMIENTO DE VARIAS DISFUNCIONES DE MEMORIA CARACTERIZADOS POR REDUCCION DE CIERTAS FUNCIONES, TALES COMO EN EL MAL DE ALZHEIMER.
ES89121037T 1988-11-16 1989-11-14 Hidroxi-1,2,3,4-tetrahidroaminoacridinas, un procedimiento para su preparacion y su uso como medicamentos. Expired - Lifetime ES2054987T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27178888A 1988-11-16 1988-11-16

Publications (1)

Publication Number Publication Date
ES2054987T3 true ES2054987T3 (es) 1994-08-16

Family

ID=23037088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89121037T Expired - Lifetime ES2054987T3 (es) 1988-11-16 1989-11-14 Hidroxi-1,2,3,4-tetrahidroaminoacridinas, un procedimiento para su preparacion y su uso como medicamentos.

Country Status (15)

Country Link
EP (1) EP0369388B1 (es)
KR (1) KR0156241B1 (es)
AT (1) ATE89553T1 (es)
CA (1) CA2003023C (es)
DE (1) DE68906647T2 (es)
DK (1) DK168290B1 (es)
ES (1) ES2054987T3 (es)
FI (1) FI90417C (es)
HU (2) HU208674B (es)
IE (1) IE63038B1 (es)
IL (1) IL92307A0 (es)
NO (1) NO894547L (es)
NZ (1) NZ231376A (es)
PT (1) PT92319B (es)
ZA (1) ZA898720B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200462B (es) * 1990-09-27 1993-02-21 Hoechst Roussel Pharma
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
WO2019207604A1 (en) * 2018-04-25 2019-10-31 Rajiv Gandhi Centre For Biotechnology Tacrine derivatives targeting nmda receptor, acetylcholine esterase, butyryl choline and beta secretase activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179383B1 (en) * 1984-10-25 1991-05-29 Hoechst-Roussel Pharmaceuticals Incorporated 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments
FI91401C (fi) * 1987-03-17 1994-06-27 Hoechst Roussel Pharma Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi

Also Published As

Publication number Publication date
KR900007809A (ko) 1990-06-02
FI90417C (fi) 1994-02-10
EP0369388B1 (en) 1993-05-19
ZA898720B (en) 1990-08-29
ATE89553T1 (de) 1993-06-15
DK571989D0 (da) 1989-11-15
IE893659L (en) 1990-05-16
FI90417B (fi) 1993-10-29
EP0369388A1 (en) 1990-05-23
DE68906647D1 (de) 1993-06-24
HU211701A9 (en) 1995-12-28
NO894547D0 (no) 1989-11-15
DK168290B1 (da) 1994-03-07
NO894547L (no) 1990-05-18
DK571989A (da) 1990-05-17
IL92307A0 (en) 1990-07-26
NZ231376A (en) 1992-05-26
HU895931D0 (en) 1990-02-28
HU208674B (en) 1993-12-28
PT92319A (pt) 1990-05-31
IE63038B1 (en) 1995-03-22
FI895416A0 (fi) 1989-11-14
CA2003023A1 (en) 1990-05-16
DE68906647T2 (de) 1993-10-07
PT92319B (pt) 1995-08-09
KR0156241B1 (ko) 1998-11-16
CA2003023C (en) 2001-05-29
HUT53087A (en) 1990-09-28

Similar Documents

Publication Publication Date Title
PH25571A (en) Alpha'-alkyl-4-amino-3-quinolinemethanols, 1-(4-aralkylamino-3-quinolinyl) alaknones, their use as medicaments
ES2120404T3 (es) Heteroarilamino- y heteroariloxipiridinaminas y compuestos afines, un procedimiento para su preparacion y su uso como medicamentos.
AU541976B2 (en) Isoquinoline derivatives
ATE50571T1 (de) Dihydropyridin-carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
ES2054987T3 (es) Hidroxi-1,2,3,4-tetrahidroaminoacridinas, un procedimiento para su preparacion y su uso como medicamentos.
PT92234A (pt) Processo para a preparacao de 1,2,3,4-tetraidro-1,9-acridinodiaminas
ES2064533T3 (es) Acido(1,2,3,4-tetrahidro-9-acridinimino)-ciclohexanocarboxilico y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos.
FI943875A (fi) 2,3,4,5-Tetrahydro-1H-3-bentsatsepiinejä ja niiden farmaseuttisesti hyväksyttäviä happoadditiosuoloja
MX25922A (es) Pirido (3,4-b) pirrolo (1,2-e)(1,4,5)oxadiazepinasy compuestos analogos relacionados un procedimiento para su preparacion y su uso como medicamentos
ES2072334T3 (es) Derivados de 4,5,5a,6-tetrahidro-3h-isoxazolo(5,4,3-kl)acridinas, un procedimiento para su preparacion y su uso como medicamentos.
ES2033859T3 (es) Acidos y esteres 2-amino-3-aroil-gamma-oxobencenbutanoicos.
ATE7497T1 (de) Imidazodiazepin-derivate, verfahren und zwischenprodukte zu ihrer herstellung, diese enthaltende arzneimittel und deren therapeutische verwendung.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 369388

Country of ref document: ES