ES2064533T3 - Acido(1,2,3,4-tetrahidro-9-acridinimino)-ciclohexanocarboxilico y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents
Acido(1,2,3,4-tetrahidro-9-acridinimino)-ciclohexanocarboxilico y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos.Info
- Publication number
- ES2064533T3 ES2064533T3 ES90111814T ES90111814T ES2064533T3 ES 2064533 T3 ES2064533 T3 ES 2064533T3 ES 90111814 T ES90111814 T ES 90111814T ES 90111814 T ES90111814 T ES 90111814T ES 2064533 T3 ES2064533 T3 ES 2064533T3
- Authority
- ES
- Spain
- Prior art keywords
- cyclohexanocarboxilico
- acridinimino
- tetrahydro
- medicines
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE PRESENTAN LOS COMPUESTOS DE LA FORMULA (I) EN DONDE X ES HIDROGENO, ALQUIL INFERIOR, ALCOXIDO INFERIOR O HALOGENO; R CUANDO ESTA PRESENTE ES HIDROGENO, ALQUIL INFERIOR O ALQUIL INFERIOR DE ARIL; R1 ES HIDROGENO, ALQUIL INFERIOR O ALQUIL INFERIOR DE ARIL; Y R2 CUANDO ESTA PRESENTE ES HIDROGENO O ALQUIL INFERIOR. DICHOS COMPUESTOS SON UTILES PARA ALIVIAR VARIOS DISFUNCIONES DE MEMORIA CARACTERIZADAS POR UNA DISMINUCION DE LA FUNCION COLINERGICA, TALES COMO LA ENFERMEDAD DE ALZHEIMER.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/371,228 US4999358A (en) | 1989-06-26 | 1989-06-26 | (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064533T3 true ES2064533T3 (es) | 1995-02-01 |
Family
ID=23463058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90111814T Expired - Lifetime ES2064533T3 (es) | 1989-06-26 | 1990-06-22 | Acido(1,2,3,4-tetrahidro-9-acridinimino)-ciclohexanocarboxilico y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos. |
Country Status (17)
Country | Link |
---|---|
US (1) | US4999358A (es) |
EP (1) | EP0405342B1 (es) |
JP (1) | JP2600013B2 (es) |
KR (1) | KR0163186B1 (es) |
AT (1) | ATE115133T1 (es) |
AU (1) | AU625221B2 (es) |
CA (1) | CA2019717C (es) |
DE (1) | DE69014730T2 (es) |
DK (1) | DK0405342T3 (es) |
ES (1) | ES2064533T3 (es) |
FI (1) | FI96307C (es) |
IE (1) | IE65462B1 (es) |
IL (3) | IL94854A (es) |
NO (1) | NO177053C (es) |
NZ (1) | NZ234199A (es) |
PT (1) | PT94472B (es) |
ZA (1) | ZA904914B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2640508B1 (fr) * | 1988-12-19 | 1994-07-01 | Dietlin Francois | Nouvelles compositions et nouveaux produits pharmaceutiques assurant la regeneration de leucocytes et leur emploi pour le traitement du syndrome immuno-deficitaire |
US5149813A (en) * | 1989-06-26 | 1992-09-22 | Hoechst-Roussel Pharmaceuticals Incorporated | Process for (1,2,3,4-tetrahydro-9-acridinimino)cyclohexane carboxylic acid and related compounds |
US6100276A (en) * | 1996-04-12 | 2000-08-08 | Aventis Pharmaceuticals Inc. | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
US5968517A (en) * | 1996-05-23 | 1999-10-19 | Duncan; Kelvin Winston | Process for extraction of proanthocyanidins from botanical material |
CN1535682A (zh) | 1998-09-30 | 2004-10-13 | ����ҩƷ��ҵ��ʽ���� | 改善膀胱排泄能力的药物 |
US8328939B2 (en) * | 2004-05-12 | 2012-12-11 | Applied Materials, Inc. | Diffuser plate with slit valve compensation |
WO2012154879A2 (en) * | 2011-05-09 | 2012-11-15 | Van Andel Research Institute | Autophagy inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB595603A (en) * | 1944-08-21 | 1947-12-10 | Ward Blenkinsop & Co Ltd | Process for the production of arylamino acridine derivatives |
DK569087A (da) * | 1986-10-31 | 1988-05-01 | Sumitomo Pharma | Quinolin-derivater, deres fremstilling og anvendelse |
US4851536A (en) * | 1987-05-07 | 1989-07-25 | American Home Products Corporation | Cyclohexylquinolines as inhibitors of interleukin 1 |
EP0306826A1 (en) * | 1987-09-08 | 1989-03-15 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(substituted alkylidene)fused bicycloalkylidene and hetero-alkylidene quinolinamines, a process for their preparation and their use as medicaments |
IL87861A0 (en) * | 1987-10-05 | 1989-03-31 | Pfizer | 4-aminopyridine derivatives |
-
1989
- 1989-06-26 US US07/371,228 patent/US4999358A/en not_active Expired - Fee Related
-
1990
- 1990-06-22 EP EP90111814A patent/EP0405342B1/en not_active Expired - Lifetime
- 1990-06-22 ES ES90111814T patent/ES2064533T3/es not_active Expired - Lifetime
- 1990-06-22 DK DK90111814.1T patent/DK0405342T3/da active
- 1990-06-22 AT AT90111814T patent/ATE115133T1/de not_active IP Right Cessation
- 1990-06-22 NZ NZ234199A patent/NZ234199A/en unknown
- 1990-06-22 DE DE69014730T patent/DE69014730T2/de not_active Expired - Fee Related
- 1990-06-24 IL IL9485490A patent/IL94854A/en not_active IP Right Cessation
- 1990-06-24 IL IL10700190A patent/IL107001A/en not_active IP Right Cessation
- 1990-06-25 ZA ZA904914A patent/ZA904914B/xx unknown
- 1990-06-25 KR KR1019900009374A patent/KR0163186B1/ko not_active IP Right Cessation
- 1990-06-25 FI FI903181A patent/FI96307C/fi active IP Right Grant
- 1990-06-25 AU AU57753/90A patent/AU625221B2/en not_active Ceased
- 1990-06-25 PT PT94472A patent/PT94472B/pt not_active IP Right Cessation
- 1990-06-25 JP JP2164371A patent/JP2600013B2/ja not_active Expired - Fee Related
- 1990-06-25 NO NO902813A patent/NO177053C/no not_active IP Right Cessation
- 1990-06-25 IE IE229090A patent/IE65462B1/en not_active IP Right Cessation
- 1990-06-25 CA CA002019717A patent/CA2019717C/en not_active Expired - Fee Related
-
1993
- 1993-09-14 IL IL107001A patent/IL107001A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2019717A1 (en) | 1990-12-26 |
ATE115133T1 (de) | 1994-12-15 |
IE902290A1 (en) | 1991-01-16 |
IE902290L (en) | 1990-12-26 |
DE69014730D1 (de) | 1995-01-19 |
IL94854A (en) | 1994-08-26 |
EP0405342A1 (en) | 1991-01-02 |
FI96307B (fi) | 1996-02-29 |
ZA904914B (en) | 1992-02-26 |
IL107001A (en) | 1994-10-21 |
FI903181A0 (fi) | 1990-06-25 |
KR910000652A (ko) | 1991-01-29 |
JP2600013B2 (ja) | 1997-04-16 |
NO177053C (no) | 1995-07-12 |
EP0405342B1 (en) | 1994-12-07 |
DE69014730T2 (de) | 1995-05-11 |
KR0163186B1 (ko) | 1998-12-01 |
IL94854A0 (en) | 1991-04-15 |
NO902813L (no) | 1990-12-27 |
NZ234199A (en) | 1992-05-26 |
US4999358A (en) | 1991-03-12 |
AU625221B2 (en) | 1992-07-02 |
CA2019717C (en) | 2001-01-23 |
IL107001A0 (en) | 1993-12-28 |
PT94472B (pt) | 1997-05-28 |
JPH0395161A (ja) | 1991-04-19 |
FI96307C (fi) | 1996-06-10 |
DK0405342T3 (da) | 1995-05-15 |
NO177053B (no) | 1995-04-03 |
NO902813D0 (no) | 1990-06-25 |
IE65462B1 (en) | 1995-11-01 |
AU5775390A (en) | 1991-01-03 |
PT94472A (pt) | 1991-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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