IE49938B1 - Trans-quinazoline derivatives,process for their preparation,intermediates,and medicaments containing said quinazoline derivatives - Google Patents

Trans-quinazoline derivatives,process for their preparation,intermediates,and medicaments containing said quinazoline derivatives

Info

Publication number
IE49938B1
IE49938B1 IE1412/80A IE141280A IE49938B1 IE 49938 B1 IE49938 B1 IE 49938B1 IE 1412/80 A IE1412/80 A IE 1412/80A IE 141280 A IE141280 A IE 141280A IE 49938 B1 IE49938 B1 IE 49938B1
Authority
IE
Ireland
Prior art keywords
trans
alkyl
general formula
oxo
quinazolin
Prior art date
Application number
IE1412/80A
Other languages
English (en)
Other versions
IE801412L (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE801412L publication Critical patent/IE801412L/xx
Publication of IE49938B1 publication Critical patent/IE49938B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IE1412/80A 1979-07-09 1980-07-08 Trans-quinazoline derivatives,process for their preparation,intermediates,and medicaments containing said quinazoline derivatives IE49938B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5572879A 1979-07-09 1979-07-09
US06/142,903 US4281127A (en) 1979-07-09 1980-04-23 Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives

Publications (2)

Publication Number Publication Date
IE801412L IE801412L (en) 1981-01-09
IE49938B1 true IE49938B1 (en) 1986-01-08

Family

ID=26734565

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1412/80A IE49938B1 (en) 1979-07-09 1980-07-08 Trans-quinazoline derivatives,process for their preparation,intermediates,and medicaments containing said quinazoline derivatives

Country Status (21)

Country Link
US (1) US4281127A (enExample)
EP (1) EP0023594B1 (enExample)
AR (1) AR226854A1 (enExample)
AU (1) AU521014B2 (enExample)
CA (1) CA1134825A (enExample)
DE (1) DE3067830D1 (enExample)
DK (1) DK150483C (enExample)
ES (2) ES8106302A1 (enExample)
FI (1) FI74279C (enExample)
GR (1) GR65952B (enExample)
HK (1) HK52187A (enExample)
HU (1) HU184797B (enExample)
IE (1) IE49938B1 (enExample)
IL (1) IL60514A (enExample)
MC (1) MC1333A1 (enExample)
NO (1) NO154426C (enExample)
NZ (1) NZ194259A (enExample)
PH (1) PH16413A (enExample)
PT (1) PT71512B (enExample)
SG (1) SG20887G (enExample)
YU (1) YU42348B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599336A (en) * 1983-08-08 1986-07-08 Hoffmann-La Roche Inc. Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US6706721B1 (en) * 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7009049B2 (en) * 2002-02-15 2006-03-07 Cytokinetics, Inc. Syntheses of quinazolinones
US7214800B2 (en) * 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
US7038048B2 (en) * 2002-05-23 2006-05-02 Cytokinetics, Inc. 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
US7041676B2 (en) * 2002-06-14 2006-05-09 Cytokinetics, Inc. Compounds, compositions, and methods
JP2006501201A (ja) * 2002-07-23 2006-01-12 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
EP1539180A4 (en) * 2002-08-21 2006-08-30 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
EP1558083A4 (en) * 2002-09-30 2008-04-16 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
EP1682534A2 (en) * 2003-11-03 2006-07-26 Cytokinetics, Inc. Pyrimidin-4-one compounds, compositions, and methods
EP1680420A4 (en) * 2003-11-07 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
EP1692112A4 (en) * 2003-12-08 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS, AND METHODS
UY29198A1 (es) * 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786055A (en) * 1955-02-10 1957-03-19 Mallinckrodt Chemical Works Carboxyalkyl-iodoquinazolones
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3696102A (en) * 1970-03-09 1972-10-03 Pfizer & Co C Process for the synthesis of substituted quinazolin-4-ones

Also Published As

Publication number Publication date
DK294780A (da) 1981-01-10
ES499035A0 (es) 1982-09-16
MC1333A1 (fr) 1981-04-21
YU42348B (en) 1988-08-31
IL60514A0 (en) 1980-09-16
US4281127A (en) 1981-07-28
FI74279B (fi) 1987-09-30
SG20887G (en) 1988-09-16
ES493203A0 (es) 1981-05-16
NZ194259A (en) 1984-09-28
EP0023594A1 (de) 1981-02-11
AU6024480A (en) 1981-03-12
AU521014B2 (en) 1982-03-11
DE3067830D1 (en) 1984-06-20
IL60514A (en) 1985-03-31
ES8106302A1 (es) 1981-05-16
GR65952B (enExample) 1981-01-09
PT71512B (en) 1981-12-11
YU176680A (en) 1984-12-31
PH16413A (en) 1983-09-29
CA1134825A (en) 1982-11-02
EP0023594B1 (de) 1984-05-16
DK150483B (da) 1987-03-09
FI74279C (fi) 1988-01-11
HU184797B (en) 1984-10-29
NO154426C (no) 1986-09-17
PT71512A (en) 1980-08-01
AR226854A1 (es) 1982-08-31
NO802056L (no) 1981-01-12
IE801412L (en) 1981-01-09
FI802195A7 (fi) 1981-01-10
HK52187A (en) 1987-07-17
DK150483C (da) 1987-11-09
NO154426B (no) 1986-06-09
ES8207155A1 (es) 1982-09-16

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Legal Events

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MM4A Patent lapsed