ES8106302A1 - Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico - Google Patents

Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico

Info

Publication number
ES8106302A1
ES8106302A1 ES493203A ES493203A ES8106302A1 ES 8106302 A1 ES8106302 A1 ES 8106302A1 ES 493203 A ES493203 A ES 493203A ES 493203 A ES493203 A ES 493203A ES 8106302 A1 ES8106302 A1 ES 8106302A1
Authority
ES
Spain
Prior art keywords
alkyl
derivatives
trans
preparation
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493203A
Other languages
English (en)
Other versions
ES493203A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES493203A0 publication Critical patent/ES493203A0/es
Publication of ES8106302A1 publication Critical patent/ES8106302A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO TRANS-(4-OXO-4H-QUINAZOLIN-3-IL)-2-PROPENOICO DE FORMULA (I) Y DE SUS SALES CON BASES FARMACOLOGICAMENTE COMPATIBLES, EN LA QUE R1 PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE R2 ES UN RADICAL ALCOXILO INFERIOR Y R1 TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), MEDIANTE UN ACIDO MINERAL, EN UN DISOLVENTE TAL COMO AGUA O ACIDO ACETICO, A LA TEMPERATURA DE REFLUJO DEL DISOLVENTE. ESTOS COMPUESTOS SON UTILES EN EL TRATAMIENTO Y PREVENCION DE REACCIONES ALERGICAS. *FORMULA*
ES493203A 1979-07-09 1980-07-08 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico Expired ES8106302A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5572879A 1979-07-09 1979-07-09
US06/142,903 US4281127A (en) 1979-07-09 1980-04-23 Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives

Publications (2)

Publication Number Publication Date
ES493203A0 ES493203A0 (es) 1981-05-16
ES8106302A1 true ES8106302A1 (es) 1981-05-16

Family

ID=26734565

Family Applications (2)

Application Number Title Priority Date Filing Date
ES493203A Expired ES8106302A1 (es) 1979-07-09 1980-07-08 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico
ES499035A Expired ES8207155A1 (es) 1979-07-09 1981-02-02 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES499035A Expired ES8207155A1 (es) 1979-07-09 1981-02-02 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico

Country Status (21)

Country Link
US (1) US4281127A (es)
EP (1) EP0023594B1 (es)
AR (1) AR226854A1 (es)
AU (1) AU521014B2 (es)
CA (1) CA1134825A (es)
DE (1) DE3067830D1 (es)
DK (1) DK150483C (es)
ES (2) ES8106302A1 (es)
FI (1) FI74279C (es)
GR (1) GR65952B (es)
HK (1) HK52187A (es)
HU (1) HU184797B (es)
IE (1) IE49938B1 (es)
IL (1) IL60514A (es)
MC (1) MC1333A1 (es)
NO (1) NO154426C (es)
NZ (1) NZ194259A (es)
PH (1) PH16413A (es)
PT (1) PT71512B (es)
SG (1) SG20887G (es)
YU (1) YU42348B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599336A (en) * 1983-08-08 1986-07-08 Hoffmann-La Roche Inc. Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US6706721B1 (en) * 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
AU2003213092A1 (en) * 2002-02-15 2003-09-09 Smithkline Beecham Corporation Syntheses of quinazolinones
CA2485148A1 (en) * 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
AU2003270015A1 (en) * 2002-05-09 2003-12-02 Cytokinetics, Inc. Compounds, compositions, and methods
AU2003265242A1 (en) * 2002-05-23 2003-12-22 Cytokinetics, Inc. Compounds, compositions, and methods
EP1556357A4 (en) * 2002-06-14 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
AU2003256805A1 (en) * 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
EP1539180A4 (en) * 2002-08-21 2006-08-30 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
AU2003277079A1 (en) * 2002-09-30 2004-05-04 Cytokinetics, Inc. Compounds, compositions, and methods
US20050197327A1 (en) * 2003-11-03 2005-09-08 Gustave Bergnes Compounds, compositions, and methods
US20050148593A1 (en) * 2003-11-07 2005-07-07 Gustave Bergnes Compounds, compositions, and methods
US7439254B2 (en) * 2003-12-08 2008-10-21 Cytokinetics, Inc. Compounds, compositions, and methods
UY29198A1 (es) * 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786055A (en) * 1955-02-10 1957-03-19 Mallinckrodt Chemical Works Carboxyalkyl-iodoquinazolones
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3696102A (en) * 1970-03-09 1972-10-03 Pfizer & Co C Process for the synthesis of substituted quinazolin-4-ones

Also Published As

Publication number Publication date
ES499035A0 (es) 1982-09-16
SG20887G (en) 1988-09-16
NZ194259A (en) 1984-09-28
PT71512B (en) 1981-12-11
AU521014B2 (en) 1982-03-11
EP0023594B1 (de) 1984-05-16
IE49938B1 (en) 1986-01-08
DK150483B (da) 1987-03-09
GR65952B (es) 1981-01-09
FI74279C (fi) 1988-01-11
IL60514A0 (en) 1980-09-16
PH16413A (en) 1983-09-29
YU42348B (en) 1988-08-31
HU184797B (en) 1984-10-29
IE801412L (en) 1981-01-09
AU6024480A (en) 1981-03-12
EP0023594A1 (de) 1981-02-11
DE3067830D1 (en) 1984-06-20
ES8207155A1 (es) 1982-09-16
FI802195A (fi) 1981-01-10
MC1333A1 (fr) 1981-04-21
FI74279B (fi) 1987-09-30
NO154426C (no) 1986-09-17
DK294780A (da) 1981-01-10
AR226854A1 (es) 1982-08-31
HK52187A (en) 1987-07-17
NO802056L (no) 1981-01-12
CA1134825A (en) 1982-11-02
ES493203A0 (es) 1981-05-16
US4281127A (en) 1981-07-28
DK150483C (da) 1987-11-09
IL60514A (en) 1985-03-31
NO154426B (no) 1986-06-09
PT71512A (en) 1980-08-01
YU176680A (en) 1984-12-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203