ES8106302A1 - Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico - Google Patents

Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico

Info

Publication number
ES8106302A1
ES8106302A1 ES493203A ES493203A ES8106302A1 ES 8106302 A1 ES8106302 A1 ES 8106302A1 ES 493203 A ES493203 A ES 493203A ES 493203 A ES493203 A ES 493203A ES 8106302 A1 ES8106302 A1 ES 8106302A1
Authority
ES
Spain
Prior art keywords
alkyl
derivatives
trans
preparation
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493203A
Other languages
English (en)
Other versions
ES493203A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8106302A1 publication Critical patent/ES8106302A1/es
Publication of ES493203A0 publication Critical patent/ES493203A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDO TRANS-(4-OXO-4H-QUINAZOLIN-3-IL)-2-PROPENOICO DE FORMULA (I) Y DE SUS SALES CON BASES FARMACOLOGICAMENTE COMPATIBLES, EN LA QUE R1 PUEDE SER UNO DE VARIOS RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE R2 ES UN RADICAL ALCOXILO INFERIOR Y R1 TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), MEDIANTE UN ACIDO MINERAL, EN UN DISOLVENTE TAL COMO AGUA O ACIDO ACETICO, A LA TEMPERATURA DE REFLUJO DEL DISOLVENTE. ESTOS COMPUESTOS SON UTILES EN EL TRATAMIENTO Y PREVENCION DE REACCIONES ALERGICAS. *FORMULA*
ES493203A 1979-07-09 1980-07-08 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico Granted ES493203A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5572879A 1979-07-09 1979-07-09
US06/142,903 US4281127A (en) 1979-07-09 1980-04-23 Trans-3-(4-oxo-4H-quinazolin-3-yl)-2-propenoic acid derivatives

Publications (2)

Publication Number Publication Date
ES8106302A1 true ES8106302A1 (es) 1981-05-16
ES493203A0 ES493203A0 (es) 1981-05-16

Family

ID=26734565

Family Applications (2)

Application Number Title Priority Date Filing Date
ES493203A Granted ES493203A0 (es) 1979-07-09 1980-07-08 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico
ES499035A Expired ES8207155A1 (es) 1979-07-09 1981-02-02 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES499035A Expired ES8207155A1 (es) 1979-07-09 1981-02-02 Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico

Country Status (21)

Country Link
US (1) US4281127A (es)
EP (1) EP0023594B1 (es)
AR (1) AR226854A1 (es)
AU (1) AU521014B2 (es)
CA (1) CA1134825A (es)
DE (1) DE3067830D1 (es)
DK (1) DK150483C (es)
ES (2) ES493203A0 (es)
FI (1) FI74279C (es)
GR (1) GR65952B (es)
HK (1) HK52187A (es)
HU (1) HU184797B (es)
IE (1) IE49938B1 (es)
IL (1) IL60514A (es)
MC (1) MC1333A1 (es)
NO (1) NO154426C (es)
NZ (1) NZ194259A (es)
PH (1) PH16413A (es)
PT (1) PT71512B (es)
SG (1) SG20887G (es)
YU (1) YU42348B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599336A (en) * 1983-08-08 1986-07-08 Hoffmann-La Roche Inc. Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
US6706721B1 (en) * 1998-04-29 2004-03-16 Osi Pharmaceuticals, Inc. N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US7087613B2 (en) * 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
AU2003213092A1 (en) * 2002-02-15 2003-09-09 Smithkline Beecham Corporation Syntheses of quinazolinones
BR0309892A2 (pt) * 2002-05-09 2011-04-05 Cytokinetics Inc composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto
JP2005530785A (ja) * 2002-05-09 2005-10-13 サイトキネティクス・インコーポレーテッド 化合物、組成物、及び方法
US7038048B2 (en) * 2002-05-23 2006-05-02 Cytokinetics, Inc. 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use
EP1556357A4 (en) * 2002-06-14 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
AU2003256805A1 (en) * 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
EP1558083A4 (en) * 2002-09-30 2008-04-16 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
JP2007510652A (ja) * 2003-11-03 2007-04-26 サイトキネティクス・インコーポレーテッド ピリミジン−４−オン化合物、組成物、および方法
EP1680420A4 (en) * 2003-11-07 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
JP2007513154A (ja) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
UY29198A1 (es) * 2004-11-09 2006-05-31 Cancer Rec Tech Ltd Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786055A (en) * 1955-02-10 1957-03-19 Mallinckrodt Chemical Works Carboxyalkyl-iodoquinazolones
US3517005A (en) * 1967-10-26 1970-06-23 Pfizer & Co C Certain 2- and 4-substituted quinazolines
US3696102A (en) * 1970-03-09 1972-10-03 Pfizer & Co C Process for the synthesis of substituted quinazolin-4-ones

Also Published As

Publication number Publication date
NO154426C (no) 1986-09-17
FI74279B (fi) 1987-09-30
PT71512A (en) 1980-08-01
IE801412L (en) 1981-01-09
FI74279C (fi) 1988-01-11
DK150483B (da) 1987-03-09
CA1134825A (en) 1982-11-02
NZ194259A (en) 1984-09-28
AU6024480A (en) 1981-03-12
IL60514A0 (en) 1980-09-16
NO802056L (no) 1981-01-12
IL60514A (en) 1985-03-31
DE3067830D1 (en) 1984-06-20
EP0023594B1 (de) 1984-05-16
YU176680A (en) 1984-12-31
PT71512B (en) 1981-12-11
ES499035A0 (es) 1982-09-16
AR226854A1 (es) 1982-08-31
DK294780A (da) 1981-01-10
US4281127A (en) 1981-07-28
IE49938B1 (en) 1986-01-08
ES8207155A1 (es) 1982-09-16
SG20887G (en) 1988-09-16
YU42348B (en) 1988-08-31
DK150483C (da) 1987-11-09
FI802195A (fi) 1981-01-10
GR65952B (es) 1981-01-09
HU184797B (en) 1984-10-29
ES493203A0 (es) 1981-05-16
AU521014B2 (en) 1982-03-11
PH16413A (en) 1983-09-29
NO154426B (no) 1986-06-09
EP0023594A1 (de) 1981-02-11
MC1333A1 (fr) 1981-04-21
HK52187A (en) 1987-07-17

Similar Documents

Publication Publication Date Title
ES8207155A1 (es) Un procedimiento para la preparacion de derivados de acido trans-(4-oxo-4h-quinazolin-3-il)-2-propenoico
AU557691B2 (en) 2-penem antibiotics and their oxa-aza-, and carba analogues
ES8706664A1 (es) Procedimiento para preparar compuestos carbostirilicos
ES8503667A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina.
ES8702427A1 (es) Un procedimiento para preparar derivados de 1,3-difosfonato
DE3170937D1 (en) 2-(1,4-benzodioxan-2-ylalkyl) imidazoles, their preparation and pharmaceutical compositions containing them
ATE71944T1 (de) Thiazolderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
ES8205770A1 (es) Procedimiento para la preparacion de derivados de 2,3-indo- lediona
ES8707217A1 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina
ES8500953A1 (es) Procedimiento para preparar derivados de tieno-tiazol
ES474367A1 (es) Procedimiento de preparacion de nuevos derivados del benzo- (d)tiazol.
EP0185221A3 (en) Process for the preparation of aminothiazolylacetic-acid derivatives
ES8801805A1 (es) Procedimiento para la obtencion de nuevos derivados de isoxazol
ES8106128A1 (es) Un procedimiento para la preparacion de derivados de ciclo- hexadieno
GR3000904T3 (en) Amide derivatives
ES8607943A1 (es) Procedimiento para la obtencion de derivados del 3-(ureidociclohexilamino)-propan-1, 2-diol
IE810901L (en) Naphthotriazoles.
ES2002113A6 (es) Procedimiento para la preparacion de derivados de 1-alquil-ergolinil-tiourea
ES8706623A1 (es) Procedimiento de preparar compuestos amidicos farmacologicamente activos
FR2312244A1 (fr) Nouvelles 2-imidazolines et leur utilisation comme agents hypoglycemiques
ES8205804A1 (es) Un procedimiento para la preparacio,n de nuevos derivados de denzopirano 2,3-d-v-triazol.
ES8505665A1 (es) Procedimiento para preparar derivados acilaminofenolicos
CA1261341A (en) SPIRO[BENZOFURANE-2(3H),1'-CYCLOHEPTANES]; METHOD AND INTERMEDIATE PRODUCTS FOR PREPARING THEM; THEIR USE AS MEDICINES
ATE29133T1 (de) Troponon-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
ES8305722A1 (es) Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinolina (tetrahidroisoquinolina).

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203