ES8305722A1 - Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinolina (tetrahidroisoquinolina). - Google Patents

Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinolina (tetrahidroisoquinolina).

Info

Publication number
ES8305722A1
ES8305722A1 ES510879A ES510879A ES8305722A1 ES 8305722 A1 ES8305722 A1 ES 8305722A1 ES 510879 A ES510879 A ES 510879A ES 510879 A ES510879 A ES 510879A ES 8305722 A1 ES8305722 A1 ES 8305722A1
Authority
ES
Spain
Prior art keywords
preparation
lower alkyl
processes
compounds
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES510879A
Other languages
English (en)
Other versions
ES510879A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES510879A0 publication Critical patent/ES510879A0/es
Publication of ES8305722A1 publication Critical patent/ES8305722A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TETRAHIDROISOQUINOLINA, Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R Y R SON ALQUILO O FENILALQUILO INFERIOR; R ES HIDROGENO O ALQUILO INFERIOR Y R ES HIDROGENO, ALQUILO INFERIOR O ARALQUILO. CONSISTE EN LA REACCION DE FOSGENO CON UN COMPUESTO RACEMICO U OPTICAMENTE ACTIVO DE FORMULA R NHCH CHR COOR , EN LA QUE R ES ALQUILO INFERIOR, Y R Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); SEGUIDA DE LA REACCION DE CONDENSACION DEL PRODUCTO FORMADO, EN UN DISOLVENTE INERTE, A UNA TEMPERATURA ENTRE 0 C Y 80 C. TAMBIEN SE PUEDE HACER REACCIONAR DIRECTAMENTE EL FOSGENO CON UN COMPUESTO DE FORMULA (II), EN LA QUE R ES ALQUILO INFERIOR O ARALQUILO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES HIPOTENSORES.
ES510879A 1981-03-27 1982-03-26 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinolina (tetrahidroisoquinolina). Expired ES8305722A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56045727A JPS57159771A (en) 1981-03-27 1981-03-27 Tetrahydroisoquinoline derivative and its preparation

Publications (2)

Publication Number Publication Date
ES510879A0 ES510879A0 (es) 1983-04-16
ES8305722A1 true ES8305722A1 (es) 1983-04-16

Family

ID=12727349

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510879A Expired ES8305722A1 (es) 1981-03-27 1982-03-26 Un procedimiento para la preparacion de nuevos derivados de tetrahidroisoquinolina (tetrahidroisoquinolina).
ES520336A Granted ES520336A0 (es) 1981-03-27 1983-03-04 Un procedimiento para la preparacion de derivados de tetrahidroisoquinolina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES520336A Granted ES520336A0 (es) 1981-03-27 1983-03-04 Un procedimiento para la preparacion de derivados de tetrahidroisoquinolina.

Country Status (4)

Country Link
EP (1) EP0061745A1 (es)
JP (1) JPS57159771A (es)
KR (1) KR830009039A (es)
ES (2) ES8305722A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5910570A (ja) * 1982-07-08 1984-01-20 Wakamoto Pharmaceut Co Ltd 新規イソカルボスチリル誘導体及びその製法
CN106542961B (zh) * 2016-11-04 2019-02-01 山东铂源药业有限公司 一种消旋卡多曲中间体的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof

Also Published As

Publication number Publication date
KR830009039A (ko) 1983-12-17
ES8502094A1 (es) 1984-04-16
EP0061745A1 (en) 1982-10-06
ES520336A0 (es) 1984-04-16
JPS57159771A (en) 1982-10-01
ES510879A0 (es) 1983-04-16

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