IE48077B1 - Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents - Google Patents

Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents

Info

Publication number
IE48077B1
IE48077B1 IE31/79A IE3179A IE48077B1 IE 48077 B1 IE48077 B1 IE 48077B1 IE 31/79 A IE31/79 A IE 31/79A IE 3179 A IE3179 A IE 3179A IE 48077 B1 IE48077 B1 IE 48077B1
Authority
IE
Ireland
Prior art keywords
formula
hydrogen
compound
cis
acid
Prior art date
Application number
IE31/79A
Other languages
English (en)
Other versions
IE790031L (en
Inventor
Guramufusein Kasawara Fuaizura
Jii Heidaa Jon
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/881,780 external-priority patent/US4229463A/en
Priority claimed from US05/891,298 external-priority patent/US4194002A/en
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE790031L publication Critical patent/IE790031L/xx
Publication of IE48077B1 publication Critical patent/IE48077B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B22/00—Use of inorganic materials as active ingredients for mortars, concrete or artificial stone, e.g. accelerators or shrinkage compensating agents
    • C04B22/0013—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Structural Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IE31/79A 1978-01-09 1979-01-08 Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents IE48077B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US86782478A 1978-01-09 1978-01-09
US86781378A 1978-01-09 1978-01-09
US87283678A 1978-01-27 1978-01-27
US88178178A 1978-02-27 1978-02-27
US05/881,780 US4229463A (en) 1978-02-27 1978-02-27 Unsaturated fatty acid hydrazides
US05/891,298 US4194002A (en) 1978-03-29 1978-03-29 Cholesterol ester-reducing amides of hexahydroindolinols

Publications (2)

Publication Number Publication Date
IE790031L IE790031L (en) 1979-07-09
IE48077B1 true IE48077B1 (en) 1984-09-19

Family

ID=27560330

Family Applications (1)

Application Number Title Priority Date Filing Date
IE31/79A IE48077B1 (en) 1978-01-09 1979-01-08 Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents

Country Status (20)

Country Link
JP (1) JPS54109930A (enrdf_load_stackoverflow)
AU (1) AU529328B2 (enrdf_load_stackoverflow)
CA (1) CA1101871A (enrdf_load_stackoverflow)
CH (1) CH644842A5 (enrdf_load_stackoverflow)
CY (1) CY1294A (enrdf_load_stackoverflow)
DE (1) DE2856856A1 (enrdf_load_stackoverflow)
DK (1) DK3079A (enrdf_load_stackoverflow)
FI (1) FI790025A7 (enrdf_load_stackoverflow)
FR (1) FR2416885A1 (enrdf_load_stackoverflow)
GB (1) GB2012261B (enrdf_load_stackoverflow)
HK (1) HK80985A (enrdf_load_stackoverflow)
IE (1) IE48077B1 (enrdf_load_stackoverflow)
IL (1) IL56393A (enrdf_load_stackoverflow)
IT (1) IT1110603B (enrdf_load_stackoverflow)
KE (1) KE3546A (enrdf_load_stackoverflow)
MY (1) MY8500133A (enrdf_load_stackoverflow)
NZ (1) NZ189331A (enrdf_load_stackoverflow)
PT (1) PT69052A (enrdf_load_stackoverflow)
SE (1) SE446093B (enrdf_load_stackoverflow)
SG (1) SG42985G (enrdf_load_stackoverflow)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2937175A1 (de) * 1978-09-18 1980-03-27 Sandoz Ag Sekundaere amide von 2-alkynoylsaeuren, deren herstellung und deren pharmazeutischen zusammensetzungen
US4297349A (en) 1980-04-15 1981-10-27 Sandoz, Inc. Silicon-bearing carboxylic acids and amides
US4722927A (en) * 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
FR2633617B1 (fr) * 1988-07-04 1991-02-08 Adir Nouveaux derives du benzocycloheptene, leur procede de preparation et les compositions pharmaceutiques les renfermant
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
CA2758424C (en) * 2008-04-21 2018-03-06 Signum Biosciences, Inc. Tryptamine derivatives as pp2a methylation modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1814334B2 (de) * 1967-12-21 1973-04-19 Sumitomo Chemical Co Ltd , Osaka (Japan) Fettsaeureamide und diese verbindungen enthaltende arzneimittel
FR2000945A1 (enrdf_load_stackoverflow) * 1968-01-30 1969-09-19 Sumitomo Chemical Co
JPS5835505B2 (ja) * 1976-01-09 1983-08-03 エーザイ株式会社 Ｎ−（α−メチル−ベンジル）−脂肪酸アミド

Also Published As

Publication number Publication date
GB2012261A (en) 1979-07-25
PT69052A (fr) 1979-02-01
IL56393A (en) 1982-08-31
KE3546A (en) 1985-07-19
FR2416885A1 (fr) 1979-09-07
CH644842A5 (de) 1984-08-31
IE790031L (en) 1979-07-09
IT1110603B (it) 1985-12-23
NZ189331A (en) 1981-07-13
SE446093B (sv) 1986-08-11
MY8500133A (en) 1985-12-31
HK80985A (en) 1985-10-25
CY1294A (en) 1985-10-18
FR2416885B1 (enrdf_load_stackoverflow) 1983-04-22
JPS6323987B2 (enrdf_load_stackoverflow) 1988-05-18
SE7900142L (sv) 1979-07-10
DE2856856A1 (de) 1979-07-12
DK3079A (da) 1979-07-10
FI790025A7 (fi) 1979-07-10
CA1101871A (en) 1981-05-26
JPS54109930A (en) 1979-08-29
AU529328B2 (en) 1983-06-02
SG42985G (en) 1985-12-13
AU4323379A (en) 1979-07-19
IL56393A0 (en) 1979-03-12
IT7919059A0 (it) 1979-01-04
GB2012261B (en) 1982-12-22

Similar Documents

Publication Publication Date Title
US4448785A (en) N-Unsaturated fatty acid amides of tryptophan ester homologues and anti-cholesteric use thereof
KR100791798B1 (ko) 페르시퀴닌, 이의 제조방법 및 이를 포함하는 약제학적 조성물
JPH0347167A (ja) メバロノラクトンの複素環同族体
HK1039617A1 (en) Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory products
IE48077B1 (en) Long-chain fatty acid amides and cyclopropano analogues thereof,their production and their use as anti-atherosclerotic agents
EP0305492A1 (en) Phospholipase a 2? inhibitors
EP0055588A1 (en) Analgesic and anti-inflammatory agents
US4248893A (en) Arterial wall cholesterol ester reducing cyclopropanyl-bearing amides
Raguž et al. A modular approach to the antifungal sphingofungin family: concise total synthesis of sphingofungin A and C
US4297349A (en) Silicon-bearing carboxylic acids and amides
US4420475A (en) Silicon-bearing amides
AU2001230192B2 (en) Method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives
US4201785A (en) Cyclopropanyl-bearing hydrazides
US4456619A (en) Amides of 2-alkynoic acids and use for inhibiting accumulation of cholesterol ester in arterial walls
US4194002A (en) Cholesterol ester-reducing amides of hexahydroindolinols
AU2021227966A1 (en) Small molecule inhibitors of SLC15A4 with anti-inflammatory activity
US4855489A (en) 2-Acyloxypropylamino derivatives, processes for the preparation thereof, and pharmaceutical compositions containing them
US4185118A (en) Benzocycloalkylamides
KR20010071197A (ko) ｓＰＬＡ2 억제제 에스테르
US4229463A (en) Unsaturated fatty acid hydrazides
US4434161A (en) Sulfur and silicon-containing fatty acid amides
CA2254152C (fr) Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US4611063A (en) Silicon-bearing amides
US4296240A (en) Silacycloalkane amides
US4384124A (en) Cyclopropanyl-bearing amides of tryptophane