IE46726B1 - Esters of (6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid - Google Patents

Esters of (6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid

Info

Publication number
IE46726B1
IE46726B1 IE760/78A IE76078A IE46726B1 IE 46726 B1 IE46726 B1 IE 46726B1 IE 760/78 A IE760/78 A IE 760/78A IE 76078 A IE76078 A IE 76078A IE 46726 B1 IE46726 B1 IE 46726B1
Authority
IE
Ireland
Prior art keywords
formula
fur
ceph
cefuroxime
methoxyiminoacetamido
Prior art date
Application number
IE760/78A
Other languages
English (en)
Other versions
IE780760L (en
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of IE780760L publication Critical patent/IE780760L/xx
Publication of IE46726B1 publication Critical patent/IE46726B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IE760/78A 1977-04-19 1978-04-18 Esters of (6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid IE46726B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB16202/77A GB1598568A (en) 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid

Publications (2)

Publication Number Publication Date
IE780760L IE780760L (en) 1978-10-19
IE46726B1 true IE46726B1 (en) 1983-09-07

Family

ID=10073017

Family Applications (1)

Application Number Title Priority Date Filing Date
IE760/78A IE46726B1 (en) 1977-04-19 1978-04-18 Esters of (6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid

Country Status (20)

Country Link
JP (1) JPS53132592A (it)
KR (1) KR840000081B1 (it)
AT (1) AT363183B (it)
AU (1) AU521098B2 (it)
BE (1) BE866093A (it)
CA (1) CA1093068A (it)
CH (1) CH639096A5 (it)
DE (1) DE2816873A1 (it)
DK (1) DK147513C (it)
ES (1) ES468895A1 (it)
FR (1) FR2387988A1 (it)
GB (1) GB1598568A (it)
IE (1) IE46726B1 (it)
IL (1) IL54531A (it)
IT (1) IT1104842B (it)
NL (1) NL7804097A (it)
NZ (1) NZ186998A (it)
SE (1) SE433748B (it)
YU (1) YU90978A (it)
ZA (1) ZA782211B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482587A1 (fr) * 1980-05-14 1981-11-20 Poudres & Explosifs Ste Nale Procede de synthese de chloroformiates a-chlores et nouveaux chloroformiates a-chlores
AU8166182A (en) * 1981-03-23 1982-09-30 Kyoto Yakuhin Kogyo K.K. Cephalosporin derivatives
SE454879B (sv) * 1982-06-29 1988-06-06 Astra Laekemedel Ab Alfa-bromodietylkarbonat samt dess anvendning som mellanprodukt vid framstellning av penicillin g
GB2123821B (en) * 1982-06-29 1987-04-23 Astra Laekemedel Ab At-halogeno diethyl carbonates and their use in the preparation of antibiotics
FR2532933B1 (fr) * 1982-06-29 1987-11-13 Astra Laekemedel Ab Perfectionnements apportes a la preparation d'antibiotiques
IT1190897B (it) * 1982-06-29 1988-02-24 Opos Biochimica Srl Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
US4606865A (en) * 1982-09-20 1986-08-19 Astra Lakemedel Aktiebolag Methods for the preparation of α-bromodiethylcarbonate
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
FR2551058B1 (fr) * 1983-08-26 1986-09-26 Poudres & Explosifs Ste Nale Procede de preparation de chloroformiates a-chlores
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
US4612143A (en) * 1984-09-17 1986-09-16 Societe Nationale Des Poudres Et Explosifs Process for the preparation of fluoroformates
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates
KR100342944B1 (ko) 1999-11-08 2002-07-02 민경윤 고순도 세프포독심 프록세틸의 제조방법
GB0301938D0 (en) * 2003-01-28 2003-02-26 Biochemie Gmbh Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
CA1093549A (en) * 1976-02-16 1981-01-13 Michael Gregson Cephalosporin antibiotics

Also Published As

Publication number Publication date
CA1093068A (en) 1981-01-06
SE7804400L (sv) 1978-10-20
JPS53132592A (en) 1978-11-18
IL54531A (en) 1981-07-31
KR830000246A (ko) 1983-03-30
GB1598568A (en) 1981-09-23
AU3518778A (en) 1979-10-25
AU521098B2 (en) 1982-03-18
DK168778A (da) 1978-10-20
DE2816873A1 (de) 1978-11-02
FR2387988B1 (it) 1982-06-11
IE780760L (en) 1978-10-19
IT7848941A0 (it) 1978-04-18
IL54531A0 (en) 1978-07-31
SE433748B (sv) 1984-06-12
BE866093A (fr) 1978-10-18
YU90978A (en) 1983-01-21
AT363183B (de) 1981-07-10
NL7804097A (nl) 1978-10-23
DK147513B (da) 1984-09-10
KR840000081B1 (ko) 1984-02-08
ATA274878A (de) 1980-12-15
ZA782211B (en) 1979-04-25
CH639096A5 (en) 1983-10-31
NZ186998A (en) 1981-05-01
FR2387988A1 (fr) 1978-11-17
IT1104842B (it) 1985-10-28
ES468895A1 (es) 1978-12-01
DK147513C (da) 1985-03-18

Similar Documents

Publication Publication Date Title
US4267320A (en) Cephalosporin antibiotics
IE46726B1 (en) Esters of (6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
CH634578A5 (de) Verfahren zur herstellung von neuen cephalosporinderivaten.
HU190442B (en) Process for producing new cepheme-carboxylic acid derivatives
GB1571683A (en) Ester derivatives of cefuroxime
US4463002A (en) Syn-isomers of 7-substituted-3-cephem-4-carboxylic acid esters
US4602012A (en) Cephalosporin antibiotics
CH662120A5 (de) Verfahren zur herstellung von cephalosporinen.
US4918068A (en) Cephem compounds
US4496562A (en) 7-Substituted-3-cephem-4-carboxylic acid esters
DD282691A5 (de) Verfahren zur herstellung von cephalosporin
JPH041757B2 (it)
GB2092575A (en) 7-acylaminocephalosporanic acid derivatives
US4446317A (en) Cephalosporin antibiotics
DE69613385T2 (de) Cephemverbindungen
PT92890A (pt) Processo para a preparacao de derivados de cefalosporina e de composicoes farmaceuticas que os contem
JPH021835B2 (it)
GB1572993A (en) Ester derivatives of cefuroxime
US4385054A (en) 1-Acetoxyethyl-3-(2-chloroethylcarbamoyloxymethyl)-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylate
KR0157589B1 (ko) 신규 세팔로스포린계 항생제 및 이의 제조방법
JPS6156238B2 (it)
US4761409A (en) Cephem derivatives
KR830001543B1 (ko) 세파로스포린 항생물질의 제조방법
EP0108627A2 (en) Cephalosporin derivatives and process for producing the same
JPH01131183A (ja) セフエム誘導体およびその製法