IE38102B1 - New quinazoline compounds and processes for their production - Google Patents
New quinazoline compounds and processes for their productionInfo
- Publication number
- IE38102B1 IE38102B1 IE1437/73A IE143773A IE38102B1 IE 38102 B1 IE38102 B1 IE 38102B1 IE 1437/73 A IE1437/73 A IE 1437/73A IE 143773 A IE143773 A IE 143773A IE 38102 B1 IE38102 B1 IE 38102B1
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- reacted
- compounds
- product
- alkylthiophenyl
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical compound NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- IOHPVZBSOKLVMN-UHFFFAOYSA-N 2-(2-phenylethyl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1CCC1=CC=CC=C1 IOHPVZBSOKLVMN-UHFFFAOYSA-N 0.000 abstract 1
- KLGQWSOYKYFBTR-UHFFFAOYSA-N 2-nitrobenzamide Chemical compound NC(=O)C1=CC=CC=C1[N+]([O-])=O KLGQWSOYKYFBTR-UHFFFAOYSA-N 0.000 abstract 1
- 229910010082 LiAlH Inorganic materials 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- VYFOAVADNIHPTR-UHFFFAOYSA-N isatoic anhydride Chemical compound NC1=CC=CC=C1CO VYFOAVADNIHPTR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00282332A US3819630A (en) | 1972-08-21 | 1972-08-21 | 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38102L IE38102L (en) | 1974-02-21 |
| IE38102B1 true IE38102B1 (en) | 1977-12-21 |
Family
ID=23081024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1437/73A IE38102B1 (en) | 1972-08-21 | 1973-08-20 | New quinazoline compounds and processes for their production |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US3819630A (en:Method) |
| JP (1) | JPS4985077A (en:Method) |
| AR (1) | AR200736A1 (en:Method) |
| AT (1) | AT327923B (en:Method) |
| AU (1) | AU476177B2 (en:Method) |
| BE (1) | BE803800A (en:Method) |
| CA (1) | CA990293A (en:Method) |
| CH (1) | CH586695A5 (en:Method) |
| DE (1) | DE2342028A1 (en:Method) |
| DK (1) | DK132758C (en:Method) |
| ES (1) | ES418036A1 (en:Method) |
| FI (1) | FI57937C (en:Method) |
| FR (1) | FR2196803B1 (en:Method) |
| GB (1) | GB1379188A (en:Method) |
| IE (1) | IE38102B1 (en:Method) |
| IL (1) | IL43033A (en:Method) |
| NL (1) | NL7311458A (en:Method) |
| NO (1) | NO138660C (en:Method) |
| PH (1) | PH9220A (en:Method) |
| SE (1) | SE398120B (en:Method) |
| ZA (1) | ZA735728B (en:Method) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879395A (en) * | 1973-10-23 | 1975-04-22 | Parke Davis & Co | 3-(1-Piperazinylalkylamino)-2-cycloalken-1-one compounds and methods for their production |
| US4268511A (en) * | 1980-03-11 | 1981-05-19 | Berri-Balzac | 3-Amino(1H,3H)quinazoline-2,4-dione derivatives and their therapeutic applications |
| EP0040793B1 (en) * | 1980-05-22 | 1985-08-28 | Masayuki Ishikawa | Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof |
| JPS58159480A (ja) * | 1982-03-17 | 1983-09-21 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| JPS5955878A (ja) * | 1982-09-24 | 1984-03-31 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| JPS60169467A (ja) * | 1984-02-10 | 1985-09-02 | Chugai Pharmaceut Co Ltd | 新規なフエニルピペラジン誘導体 |
| US4711883A (en) * | 1985-09-30 | 1987-12-08 | Ortho Pharmaceutical Corporation | Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use |
| US5160727A (en) * | 1990-02-13 | 1992-11-03 | Warner-Lambert Company | Tumor cell sensitization method using quinazolinedione derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274194A (en) * | 1963-03-29 | 1966-09-20 | Miles Lab | Quinazolinedione derivatives |
-
1972
- 1972-08-21 US US00282332A patent/US3819630A/en not_active Expired - Lifetime
-
1973
- 1973-08-20 SE SE7311297A patent/SE398120B/xx unknown
- 1973-08-20 CA CA179,161A patent/CA990293A/en not_active Expired
- 1973-08-20 GB GB3932673A patent/GB1379188A/en not_active Expired
- 1973-08-20 AU AU59420/73A patent/AU476177B2/en not_active Expired
- 1973-08-20 IE IE1437/73A patent/IE38102B1/xx unknown
- 1973-08-20 BE BE134748A patent/BE803800A/xx unknown
- 1973-08-20 CH CH1194973A patent/CH586695A5/xx not_active IP Right Cessation
- 1973-08-20 AR AR249617A patent/AR200736A1/es active
- 1973-08-20 AT AT722773A patent/AT327923B/de not_active IP Right Cessation
- 1973-08-20 NL NL7311458A patent/NL7311458A/xx not_active Application Discontinuation
- 1973-08-20 FR FR7330161A patent/FR2196803B1/fr not_active Expired
- 1973-08-20 ES ES418036A patent/ES418036A1/es not_active Expired
- 1973-08-20 DK DK457173A patent/DK132758C/da active
- 1973-08-20 IL IL43033A patent/IL43033A/en unknown
- 1973-08-20 DE DE19732342028 patent/DE2342028A1/de not_active Withdrawn
- 1973-08-20 JP JP48093222A patent/JPS4985077A/ja active Pending
- 1973-08-20 FI FI2591/73A patent/FI57937C/fi active
- 1973-08-20 NO NO3283/73A patent/NO138660C/no unknown
- 1973-08-21 ZA ZA00735728A patent/ZA735728B/xx unknown
- 1973-09-26 PH PH15053*UA patent/PH9220A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US3819630A (en) | 1974-06-25 |
| ZA735728B (en) | 1975-04-30 |
| IL43033A (en) | 1976-09-30 |
| SE398120B (sv) | 1977-12-05 |
| DK132758B (da) | 1976-02-02 |
| PH9220A (en) | 1975-07-10 |
| IE38102L (en) | 1974-02-21 |
| NL7311458A (en:Method) | 1974-02-25 |
| BE803800A (fr) | 1973-12-17 |
| CA990293A (en) | 1976-06-01 |
| DE2342028A1 (de) | 1974-03-07 |
| JPS4985077A (en:Method) | 1974-08-15 |
| FR2196803B1 (en:Method) | 1976-05-14 |
| NO138660C (no) | 1978-10-18 |
| ATA722773A (de) | 1975-05-15 |
| DK132758C (da) | 1976-08-23 |
| AU476177B2 (en) | 1976-09-16 |
| GB1379188A (en) | 1975-01-02 |
| CH586695A5 (en:Method) | 1977-04-15 |
| NO138660B (no) | 1978-07-10 |
| FI57937B (fi) | 1980-07-31 |
| AU5942073A (en) | 1975-02-20 |
| FR2196803A1 (en:Method) | 1974-03-22 |
| ES418036A1 (es) | 1976-03-01 |
| AR200736A1 (es) | 1974-12-13 |
| FI57937C (fi) | 1980-11-10 |
| IL43033A0 (en) | 1973-11-28 |
| AT327923B (de) | 1976-02-25 |
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