GB1444492A - Butyramides their preparation and pharmaceutical compositions containing them - Google Patents
Butyramides their preparation and pharmaceutical compositions containing themInfo
- Publication number
- GB1444492A GB1444492A GB3829174A GB3829174A GB1444492A GB 1444492 A GB1444492 A GB 1444492A GB 3829174 A GB3829174 A GB 3829174A GB 3829174 A GB3829174 A GB 3829174A GB 1444492 A GB1444492 A GB 1444492A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- acids
- butyrimidic
- pharmaceutical compositions
- sept
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
Abstract
1444492 Butyrimidic acids ROUSSEL UCLAF 2 Sept 1974 [3 Sept 1973] 38291/74 Heading C2C Novel butyrimidic acids of the formula wherein X<SP>1</SP> 1 , X<SP>11</SP> 1 , X<SP>1</SP> 2 and X<SP>11</SP> 2 each are H, halogen, C 1-5 alkyl, C 1-5 alkoxy, C 1-5 alkylthio, CF 3 , trifluoromethoxy, trifluoromethylthio, OH or di(C 1-5 alkyl)amino, X, Y and Z each are H or C 1-5 alkyl, R 1 is H or C 1-5 alkyl, R 2 is OH or C 1-5 alkoxy and the symbols # either both represent single C-C bonds or one represents a C-C bond and the other represents a C=C bond are prepared by reacting the corresponding butyric acids or functional derivatives thereof with compounds of the formula HN(R<SP>1</SP>)R 2 . 4 - (3 - p - Chlorobenzoyl - 2 - methylphenyl)- butyryl chloride is obtained by reacting the corresponding butyric acid with thionyl chloride. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above butyrimidic acids and pharmaceutical carriers or excipients. The compounds possess analgesic and anti-inflammatory properties.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7331699A FR2242077B1 (en) | 1973-09-03 | 1973-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1444492A true GB1444492A (en) | 1976-07-28 |
Family
ID=9124547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3829174A Expired GB1444492A (en) | 1973-09-03 | 1974-09-02 | Butyramides their preparation and pharmaceutical compositions containing them |
Country Status (19)
| Country | Link |
|---|---|
| JP (1) | JPS5050345A (en) |
| AT (1) | AT335998B (en) |
| BE (1) | BE819456A (en) |
| CA (1) | CA1030552A (en) |
| CH (1) | CH587799A5 (en) |
| DD (1) | DD116028A5 (en) |
| DE (1) | DE2442124A1 (en) |
| DK (1) | DK464674A (en) |
| ES (1) | ES429717A1 (en) |
| FR (1) | FR2242077B1 (en) |
| GB (1) | GB1444492A (en) |
| HU (1) | HU168678B (en) |
| IE (1) | IE40649B1 (en) |
| IL (1) | IL45506A (en) |
| LU (1) | LU70832A1 (en) |
| NL (1) | NL7411702A (en) |
| SE (1) | SE414496B (en) |
| SU (1) | SU576919A3 (en) |
| ZA (1) | ZA745400B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0196184A2 (en) * | 1985-03-16 | 1986-10-01 | The Wellcome Foundation Limited | Aryl derivatives |
| EP0301861A1 (en) * | 1987-07-29 | 1989-02-01 | Takeda Chemical Industries, Ltd. | Cell proliferation inhibitors |
| US4977188A (en) * | 1985-12-30 | 1990-12-11 | Burroughs Wellcome Co. | Method of treating inflammation |
| US5028629A (en) * | 1990-03-28 | 1991-07-02 | Eli Lilly And Company | 5-Lipoxygenase inhibitors |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6701694A (en) | 1993-04-16 | 1994-11-08 | Mccormick & Company, Inc. | Encapsulation compositions |
| WO2006004598A2 (en) * | 2004-06-01 | 2006-01-12 | The Scripps Research Institute | Proteomic analysis |
-
1973
- 1973-09-03 FR FR7331699A patent/FR2242077B1/fr not_active Expired
-
1974
- 1974-08-05 SE SE7410046-2A patent/SE414496B/en unknown
- 1974-08-13 DD DD180466A patent/DD116028A5/xx unknown
- 1974-08-20 IL IL45506A patent/IL45506A/en unknown
- 1974-08-22 ZA ZA00745400A patent/ZA745400B/en unknown
- 1974-08-28 JP JP49098005A patent/JPS5050345A/ja active Pending
- 1974-08-30 HU HURO793A patent/HU168678B/hu unknown
- 1974-08-30 CA CA208,178A patent/CA1030552A/en not_active Expired
- 1974-08-30 LU LU70832A patent/LU70832A1/xx unknown
- 1974-09-02 BE BE148139A patent/BE819456A/en unknown
- 1974-09-02 SU SU7402063057A patent/SU576919A3/en active
- 1974-09-02 ES ES429717A patent/ES429717A1/en not_active Expired
- 1974-09-02 CH CH1190174A patent/CH587799A5/xx not_active IP Right Cessation
- 1974-09-02 GB GB3829174A patent/GB1444492A/en not_active Expired
- 1974-09-03 IE IE1819/74A patent/IE40649B1/en unknown
- 1974-09-03 AT AT710474A patent/AT335998B/en not_active IP Right Cessation
- 1974-09-03 DK DK464674A patent/DK464674A/da not_active Application Discontinuation
- 1974-09-03 DE DE2442124A patent/DE2442124A1/en not_active Withdrawn
- 1974-09-03 NL NL7411702A patent/NL7411702A/en not_active Application Discontinuation
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0196184A2 (en) * | 1985-03-16 | 1986-10-01 | The Wellcome Foundation Limited | Aryl derivatives |
| EP0196184A3 (en) * | 1985-03-16 | 1988-04-20 | The Wellcome Foundation Limited | New aryl derivatives |
| US4977188A (en) * | 1985-12-30 | 1990-12-11 | Burroughs Wellcome Co. | Method of treating inflammation |
| EP0301861A1 (en) * | 1987-07-29 | 1989-02-01 | Takeda Chemical Industries, Ltd. | Cell proliferation inhibitors |
| US5028629A (en) * | 1990-03-28 | 1991-07-02 | Eli Lilly And Company | 5-Lipoxygenase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| DK464674A (en) | 1975-05-05 |
| CA1030552A (en) | 1978-05-02 |
| IL45506A (en) | 1978-07-31 |
| CH587799A5 (en) | 1977-05-13 |
| ZA745400B (en) | 1975-10-29 |
| AU7260674A (en) | 1976-02-26 |
| JPS5050345A (en) | 1975-05-06 |
| SE414496B (en) | 1980-08-04 |
| FR2242077A1 (en) | 1975-03-28 |
| HU168678B (en) | 1976-06-28 |
| IE40649L (en) | 1975-03-03 |
| IL45506A0 (en) | 1974-11-29 |
| IE40649B1 (en) | 1979-07-18 |
| ATA710474A (en) | 1976-08-15 |
| SE7410046L (en) | 1975-03-04 |
| AT335998B (en) | 1977-04-12 |
| SU576919A3 (en) | 1977-10-15 |
| FR2242077B1 (en) | 1977-01-28 |
| DD116028A5 (en) | 1975-11-05 |
| DE2442124A1 (en) | 1975-03-06 |
| BE819456A (en) | 1975-03-03 |
| LU70832A1 (en) | 1975-06-11 |
| ES429717A1 (en) | 1977-04-01 |
| NL7411702A (en) | 1975-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |