GB1345502A - Quinazoline compounds and processes for their production - Google Patents

Quinazoline compounds and processes for their production

Info

Publication number
GB1345502A
GB1345502A GB1345502DA GB1345502A GB 1345502 A GB1345502 A GB 1345502A GB 1345502D A GB1345502D A GB 1345502DA GB 1345502 A GB1345502 A GB 1345502A
Authority
GB
United Kingdom
Prior art keywords
processes
production
quinazoline compounds
quinazoline
monohalonaphthyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB1345502A publication Critical patent/GB1345502A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1345502 Derivatives of 2,4-diaminoquinazoline PARKE DAVIS & CO 6 July 1972 31827/72 Heading C2C [Also in Division A5] The invention comprises compounds of formula and their acid addition salts, wherein Y is H, NO, HCO or Ac; Z is H, Me or Cl: and Ar is naphthyl, monohalonaphthyl or R 1-3 C 6 H 4-2 , where R is halogen, CF 3 and/or MeO.The triamines are prepared by reacting in presence of H 2 and catalyst, a 6-cyano-2,4-diamino-5-Z-quinazoline, and may then be nitrosated or acylated.
GB1345502D 1972-07-06 1972-07-06 Quinazoline compounds and processes for their production Expired GB1345502A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3182772 1972-07-06

Publications (1)

Publication Number Publication Date
GB1345502A true GB1345502A (en) 1974-01-30

Family

ID=10329006

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1345502D Expired GB1345502A (en) 1972-07-06 1972-07-06 Quinazoline compounds and processes for their production

Country Status (1)

Country Link
GB (1) GB1345502A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051415A1 (en) * 1980-10-31 1982-05-12 Warner-Lambert Company Water-soluble salts of 2,4-diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline, compositions containing such salts and the production of such salts
US4376858A (en) * 1980-10-31 1983-03-15 Warner Lambert Company 2-4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline salts
US4677219A (en) * 1986-07-17 1987-06-30 Warner-Lambert Company Substituted benzonitriles
US4853221A (en) * 1980-11-13 1989-08-01 Warner-Lambert Company Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
EP0804197A1 (en) * 1995-01-13 1997-11-05 Paul E. Kennedy Crystalline trimetrexate salts and the process for making the same
US6017922A (en) * 1998-05-18 2000-01-25 U.S. Bioscience, Inc. Thermally stable trimetrexates and processes for producing the same
US6258821B1 (en) 1999-04-26 2001-07-10 Medimmune Oncology, Inc. Compositions comprising trimetrexate and methods of their synthesis and use
EP1964577A2 (en) 2005-05-05 2008-09-03 Chroma Therapeutics Limited Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376858A (en) * 1980-10-31 1983-03-15 Warner Lambert Company 2-4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline salts
EP0051415A1 (en) * 1980-10-31 1982-05-12 Warner-Lambert Company Water-soluble salts of 2,4-diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline, compositions containing such salts and the production of such salts
US4853221A (en) * 1980-11-13 1989-08-01 Warner-Lambert Company Method for treating non-small cell lung cancer, head and neck cancers and breast cancer
US4677219A (en) * 1986-07-17 1987-06-30 Warner-Lambert Company Substituted benzonitriles
US6017921A (en) * 1995-01-13 2000-01-25 U.S. Bioscience, Inc. Crystalline trimetrexate salts and the process for making the same
EP0804197A1 (en) * 1995-01-13 1997-11-05 Paul E. Kennedy Crystalline trimetrexate salts and the process for making the same
EP0804197A4 (en) * 1995-01-13 1998-09-30 Paul E Kennedy Crystalline trimetrexate salts and the process for making the same
EP1080079A1 (en) * 1998-05-18 2001-03-07 U.S. Bioscience, Inc. Thermally stable trimetrexates and processes for producing the same
US6017922A (en) * 1998-05-18 2000-01-25 U.S. Bioscience, Inc. Thermally stable trimetrexates and processes for producing the same
US6258952B1 (en) 1998-05-18 2001-07-10 Medimmune Oncology, Inc. Thermally stable trimetrexates and processes for producing the same
EP1080079A4 (en) * 1998-05-18 2001-10-04 Us Bioscience Thermally stable trimetrexates and processes for producing the same
JP2002515493A (en) * 1998-05-18 2002-05-28 ユー．エス．バイオサイエンス，インコーポレーテッド Thermally stable trimetrexate and its manufacturing process
US6258821B1 (en) 1999-04-26 2001-07-10 Medimmune Oncology, Inc. Compositions comprising trimetrexate and methods of their synthesis and use
US6576635B2 (en) 1999-04-26 2003-06-10 Medimmune Oncology, Inc. Compositions comprising trimetrexate
EP1964577A2 (en) 2005-05-05 2008-09-03 Chroma Therapeutics Limited Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase
EP1964578A2 (en) 2005-05-05 2008-09-03 Chroma Therapeutics Limited Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase
EP3530290A1 (en) 2005-05-05 2019-08-28 GlaxoSmithKline Intellectual Property Development Limited Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years