IE35366B1 - Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable - Google Patents

Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable

Info

Publication number
IE35366B1
IE35366B1 IE76271A IE76271A IE35366B1 IE 35366 B1 IE35366 B1 IE 35366B1 IE 76271 A IE76271 A IE 76271A IE 76271 A IE76271 A IE 76271A IE 35366 B1 IE35366 B1 IE 35366B1
Authority
IE
Ireland
Prior art keywords
formula
salt
derivatives
manufacture
solvolysis
Prior art date
Application number
IE76271A
Other versions
IE35366L (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IE35366L publication Critical patent/IE35366L/en
Publication of IE35366B1 publication Critical patent/IE35366B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1356437 3-formyl cephalosporins CIBAGEIGY AG 18 June 1971 [18 June 1970] 28752/71 Heading C2A The invention comprises a process for the manufacture of a 7-amino-cephalosporanic acid derivative of the Formula I wherein X is a hydrogen atom or an acyl residue and R 1 represents a hydrogen atom, a saltforming cation or OR 1 represents a substituted methyl ester group that can be split off by solvolysis, enzymolysis, photolysis or reduction, wherein a compound of the Formula II in which X has the meaning given above and OR stands for a substituted methyl ester group that can be split off by solvolysis, enzymolysis, photolysis or reduction, is oxidized with an aliphatic sulphoxide in the presence of an anhydride of a carboxylic acid and, if desired, the resulting compound is converted into a salt or a resulting salt is converted into another salt. The compounds of Formula I may be used as the active ingredient in pharmaceutical preparations in admixture with a pharmaceutically acceptable organic or inorganic solid or liquid carrier material suitable for enteral, topical or parenteral administration. [GB1356437A]
IE76271A 1970-06-18 1971-06-14 Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable IE35366B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH923270 1970-06-18

Publications (2)

Publication Number Publication Date
IE35366L IE35366L (en) 1971-12-18
IE35366B1 true IE35366B1 (en) 1976-01-21

Family

ID=4349775

Family Applications (1)

Application Number Title Priority Date Filing Date
IE76271A IE35366B1 (en) 1970-06-18 1971-06-14 Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable

Country Status (12)

Country Link
AT (1) AT304762B (en)
BE (1) BE768653A (en)
CA (1) CA929517A (en)
CH (1) CH546794A (en)
DE (1) DE2128605A1 (en)
FR (1) FR2100776B1 (en)
GB (1) GB1356437A (en)
HU (1) HU163508B (en)
IE (1) IE35366B1 (en)
NL (1) NL7108351A (en)
SE (1) SE379354B (en)
SU (1) SU414793A3 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE412238B (en) * 1971-05-24 1980-02-25 Ciba Geigy PROCEDURE FOR PREPARING 7 BETA-AMINO-CEFEM-4-CARBOXYLIC ACID COMPOUNDS BY DECARBONYLATION OF A 3-FORMYL-CEFEM-4-CARBOXYLIC ACID COMPOUND
CH590873A5 (en) * 1972-06-29 1977-08-31 Ciba Geigy Ag Substd 7-beta-amino-cephamone carboxylic acid derivs - antibiotic inters
CA1109860A (en) * 1972-12-08 1981-09-29 Shinji Terao Process for producing lactol-type cephalosporins
US4122260A (en) * 1977-10-04 1978-10-24 Yeda Research And Development Co., Ltd. Cephalosporin derivatives
AT402929B (en) * 1994-05-25 1997-09-25 Biochemie Gmbh Novel cephalosporin derivatives, process for their preparation and their use
US5856474A (en) * 1994-04-25 1999-01-05 Biochemie Gesellschaft, M.B.H. Cephalosporin synthesis
US5631366A (en) * 1995-01-12 1997-05-20 Hoffmann-La Roche Inc. Process for making 3-formylcephem derivatives
EP1227100B1 (en) 1999-09-30 2004-05-26 Otsuka Kagaku Kabushiki Kaisha 3-cephem derivative crystal and method for preparing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH549053A (en) * 1967-11-03 1974-05-15 Ciba Geigy Ag Cephalosporanic acid derivs antibacterials feed supplements

Also Published As

Publication number Publication date
BE768653A (en) 1971-12-17
AT304762B (en) 1973-01-25
CA929517A (en) 1973-07-03
HU163508B (en) 1973-09-27
SE379354B (en) 1975-10-06
CH546794A (en) 1974-03-15
NL7108351A (en) 1971-12-21
SU414793A3 (en) 1974-02-05
IE35366L (en) 1971-12-18
DE2128605A1 (en) 1971-12-23
FR2100776B1 (en) 1974-08-30
GB1356437A (en) 1974-06-12
FR2100776A1 (en) 1972-03-24

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