IE35366B1 - Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable - Google Patents
Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainableInfo
- Publication number
- IE35366B1 IE35366B1 IE76271A IE76271A IE35366B1 IE 35366 B1 IE35366 B1 IE 35366B1 IE 76271 A IE76271 A IE 76271A IE 76271 A IE76271 A IE 76271A IE 35366 B1 IE35366 B1 IE 35366B1
- Authority
- IE
- Ireland
- Prior art keywords
- formula
- salt
- derivatives
- manufacture
- solvolysis
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004492 methyl ester group Chemical group 0.000 abstract 2
- 238000006303 photolysis reaction Methods 0.000 abstract 2
- 230000015843 photosynthesis, light reaction Effects 0.000 abstract 2
- 238000003797 solvolysis reaction Methods 0.000 abstract 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000012876 carrier material Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 229910003480 inorganic solid Inorganic materials 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH923270 | 1970-06-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35366L IE35366L (en) | 1971-12-18 |
| IE35366B1 true IE35366B1 (en) | 1976-01-21 |
Family
ID=4349775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE76271A IE35366B1 (en) | 1970-06-18 | 1971-06-14 | Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable |
Country Status (12)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE412238B (sv) * | 1971-05-24 | 1980-02-25 | Ciba Geigy | Forfarande for framstellning av 7 beta-amino-cefem-4-karboxylsyraforeningar genom dekarbonylering av en 3-formyl-cefem-4-karboxylsyraforening |
| CH590873A5 (en) * | 1972-06-29 | 1977-08-31 | Ciba Geigy Ag | Substd 7-beta-amino-cephamone carboxylic acid derivs - antibiotic inters |
| CA1109860A (en) * | 1972-12-08 | 1981-09-29 | Shinji Terao | Process for producing lactol-type cephalosporins |
| US4122260A (en) * | 1977-10-04 | 1978-10-24 | Yeda Research And Development Co., Ltd. | Cephalosporin derivatives |
| AT402929B (de) * | 1994-05-25 | 1997-09-25 | Biochemie Gmbh | Neue cephalosporinderivate, verfahren zu ihrer herstellung und ihre verwendung |
| US5856474A (en) * | 1994-04-25 | 1999-01-05 | Biochemie Gesellschaft, M.B.H. | Cephalosporin synthesis |
| US5631366A (en) * | 1995-01-12 | 1997-05-20 | Hoffmann-La Roche Inc. | Process for making 3-formylcephem derivatives |
| ATE335747T1 (de) | 1999-09-30 | 2006-09-15 | Otsuka Kagaku Kk | Kristallines 3-cephem derivat |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH549053A (de) * | 1967-11-03 | 1974-05-15 | Ciba Geigy Ag | Verfahren zur herstellung von 7-substituierten 3-desacetylisocephalosporansaeuren. |
-
1970
- 1970-06-18 CH CH546794D patent/CH546794A/xx not_active IP Right Cessation
-
1971
- 1971-06-09 DE DE19712128605 patent/DE2128605A1/de active Pending
- 1971-06-14 IE IE76271A patent/IE35366B1/xx unknown
- 1971-06-15 CA CA115657A patent/CA929517A/en not_active Expired
- 1971-06-16 SE SE780371A patent/SE379354B/xx unknown
- 1971-06-16 SU SU1672625A patent/SU414793A3/ru active
- 1971-06-17 NL NL7108351A patent/NL7108351A/xx unknown
- 1971-06-17 BE BE768653A patent/BE768653A/xx unknown
- 1971-06-17 AT AT524871A patent/AT304762B/de not_active IP Right Cessation
- 1971-06-17 HU HUCI001131 patent/HU163508B/hu unknown
- 1971-06-17 FR FR7122010A patent/FR2100776B1/fr not_active Expired
- 1971-06-18 GB GB2875271A patent/GB1356437A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE35366L (en) | 1971-12-18 |
| BE768653A (fr) | 1971-12-17 |
| SU414793A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-02-05 |
| CA929517A (en) | 1973-07-03 |
| FR2100776B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-30 |
| HU163508B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-09-27 |
| FR2100776A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-03-24 |
| SE379354B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-10-06 |
| GB1356437A (en) | 1974-06-12 |
| DE2128605A1 (de) | 1971-12-23 |
| NL7108351A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1971-12-21 |
| CH546794A (de) | 1974-03-15 |
| AT304762B (de) | 1973-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EG10530A (en) | Process for preparation of 7-aminocephalosporanic acid derivatives having a substituent at position 7,their use as antibiotics | |
| GEP19960467B (en) | Method of producing derivatives of quinoline or their pharmaceutically acceptable esters or acid-additive salts | |
| IE37757L (en) | Penicillin and cephalosporin esters | |
| IE35366B1 (en) | Process for the manufacture of cephalosporanic acid derivatives and the derivatives thus obtainable | |
| IE36084L (en) | 3-methylene cephalosporins | |
| IE34314L (en) | Dibenzodioxocine derivatives | |
| GB1300128A (en) | Derivatives of cephalosporin | |
| IE35879L (en) | Penicillins | |
| GB1325889A (en) | Derivatives of 7-aminocephalosporanic acid and process for their manufacture | |
| GB1252286A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| IE32859L (en) | Penicilloic acid derivatives. | |
| GB1203538A (en) | Cubane derivatives | |
| GB1300419A (en) | New morphinone derivatives and their preparation | |
| IE42191L (en) | 7ó-methoxy cephalosporin compounds. | |
| GB1126860A (en) | Novel 4-substituted-7- and 8-chloroquinolines and a process for the preparation thereof | |
| GB1288967A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| GB1014883A (en) | Therapeutically active derivatives of 7-amino-cephalosporanic acid and process for the manufacture of 7-amino-cephalosporanic acid | |
| GB1426200A (en) | Nahpthyridine derivatives | |
| GB1315091A (en) | 2-diethylaminoethyl nicotinate p-chlorophenoxy-isobutyric acid salt | |
| GB1423386A (en) | Derivatives of penam-3-carboxylic acid and cephem-4-carboxylic acid and processes for their manufacture | |
| GB985004A (en) | 6-methyl-ergoline i derivatives | |
| GB1381160A (en) | Penicillin and cephalosporin c antibiotics the preparation thereof and pharmaceutical compositions containing them | |
| GB1382958A (en) | Azabicyclic esters of omega- 4-biphenylyl- alkanoic acids | |
| IE43582L (en) | Desoxystreptamine derivatives | |
| GB1319204A (en) | Penicillin derivatives |