ID22982A - PIRAZOL-PIRAZOL TERSUBSTITUSI SEBAGAI INHIBITOR KINASE p38 - Google Patents
PIRAZOL-PIRAZOL TERSUBSTITUSI SEBAGAI INHIBITOR KINASE p38Info
- Publication number
- ID22982A ID22982A IDW991425A ID991425A ID22982A ID 22982 A ID22982 A ID 22982A ID W991425 A IDW991425 A ID W991425A ID 991425 A ID991425 A ID 991425A ID 22982 A ID22982 A ID 22982A
- Authority
- ID
- Indonesia
- Prior art keywords
- pirazols
- substituted
- kinase inhibitors
- kinase
- inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4757097P | 1997-05-22 | 1997-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID22982A true ID22982A (id) | 1999-12-23 |
Family
ID=21949743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW991425A ID22982A (id) | 1997-05-22 | 1998-05-22 | PIRAZOL-PIRAZOL TERSUBSTITUSI SEBAGAI INHIBITOR KINASE p38 |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1000055A1 (ko) |
JP (1) | JP2002508754A (ko) |
KR (1) | KR20010012854A (ko) |
CN (1) | CN1264377A (ko) |
AP (1) | AP1246A (ko) |
AU (1) | AU754830C (ko) |
BG (1) | BG64313B1 (ko) |
BR (1) | BR9809147A (ko) |
CA (1) | CA2291115A1 (ko) |
EA (1) | EA003925B1 (ko) |
EE (1) | EE9900527A (ko) |
GE (1) | GEP20033053B (ko) |
HU (1) | HUP0001880A3 (ko) |
ID (1) | ID22982A (ko) |
IL (1) | IL132991A (ko) |
IS (1) | IS5257A (ko) |
NO (1) | NO995695L (ko) |
NZ (1) | NZ501112A (ko) |
OA (1) | OA12981A (ko) |
PL (1) | PL337020A1 (ko) |
SK (1) | SK157899A3 (ko) |
TR (1) | TR200000235T2 (ko) |
WO (1) | WO1998052940A1 (ko) |
ZA (1) | ZA984358B (ko) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW289752B (ko) * | 1994-03-11 | 1996-11-01 | Ciba Geigy Ag | |
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
EP1019394A1 (en) | 1997-05-22 | 2000-07-19 | G.D. Searle & Co. | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
WO1998056377A1 (en) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
JP2002526388A (ja) | 1998-10-07 | 2002-08-20 | スミスクライン・ビーチャム・コーポレイション | 発作を管理するための新規な処置 |
EP1140916B1 (en) | 1998-12-16 | 2002-11-13 | Aventis Pharma Limited | Heteroaryl-cyclic acetals |
US6191147B1 (en) | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
CN1326848C (zh) | 1998-12-25 | 2007-07-18 | 帝国脏器制药株式会社 | 氨基吡唑衍生物 |
BR0009322A (pt) | 1999-03-26 | 2002-04-30 | Euro Celtique Sa | Pirazóis, imidazóis, oxazóis, tiazóis e pirróis substituìdos com arila e o uso dos mesmos |
CN1178931C (zh) * | 1999-06-03 | 2004-12-08 | 帝国脏器制药株式会社 | 取代吡唑化合物 |
US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
KR20020030791A (ko) * | 1999-08-12 | 2002-04-25 | 버텍스 파마슈티칼스 인코포레이티드 | c-JUN N-말단 키나제(JNK) 및 기타의 단백질키나제 억제제 |
AU7922100A (en) * | 1999-10-25 | 2001-05-08 | Basf Aktiengesellschaft | Agrochemical compositions containing pyrazoles as the active agents and use of said compositions as plant protection agents with a fungicidal action |
DE19952147A1 (de) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | Neue Cyclopropane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
JP2003514899A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | CSBP/p38キナーゼ阻害剤としての3,4‐ジヒドロ−(1H)−キナゾリン−2−オン化合物 |
MXPA03001420A (es) | 2000-08-14 | 2004-01-26 | Johnson & Johnson | Pirazoles sustituidos. |
CA2437248A1 (en) * | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
GB0102687D0 (en) | 2001-02-02 | 2001-03-21 | Pharmacia & Upjohn Spa | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them |
US7074801B1 (en) | 2001-04-26 | 2006-07-11 | Eisai Co., Ltd. | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof |
EP1397364B1 (en) | 2001-05-24 | 2007-07-25 | Eli Lilly And Company | Novel pyrrole derivatives as pharmaceutical agents |
MXPA04002855A (es) | 2001-09-25 | 2004-07-05 | Pharmacia Corp | Proceso para producir pirazoles sustituidos. |
US7057049B2 (en) | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
BR0311619A (pt) * | 2002-06-05 | 2005-03-08 | Pharmacia Corp | Derivados de pirazol como inibidores de cinase p38 |
GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
DE60310730T2 (de) | 2002-07-09 | 2007-05-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
GB0217786D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
US6649638B1 (en) | 2002-08-14 | 2003-11-18 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
WO2004016592A1 (en) | 2002-08-14 | 2004-02-26 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
WO2004026302A1 (en) * | 2002-09-19 | 2004-04-01 | Eli Lilly And Company | Methods of inhibiting tgf beta with substituted pyrazoles |
GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
US7622471B2 (en) | 2003-02-07 | 2009-11-24 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives having a pyridazine and pyridine functionality |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
AP2326A (en) | 2004-08-12 | 2011-11-24 | Pfizer | Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors. |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
CN101080404B (zh) | 2004-12-28 | 2011-06-08 | Aska制药株式会社 | 嘧啶基异噁唑衍生物 |
CA2643066A1 (en) * | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
CA2655999A1 (en) * | 2006-06-28 | 2008-01-03 | Aska Pharmaceutical Co., Ltd. | Treating agent of inflammatory bowel disease |
US8207203B2 (en) | 2006-06-28 | 2012-06-26 | Aska Pharmaceutical Co., Ltd. | Pyridylisoxazole derivatives |
EP2123255B1 (en) | 2007-02-16 | 2013-05-15 | ASKA Pharmaceutical Co., Ltd. | Pharmaceutical composition containing fine particle oil-based suspension |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
EA201070143A1 (ru) * | 2007-07-13 | 2010-08-30 | Аддекс Фарма С.А. | Новые гетероароматические производные и их использование в качестве положительных аллостерических модуляторов метаботропных глутаматных рецепторов |
JP5769970B2 (ja) | 2007-11-16 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
CL2009000904A1 (es) * | 2008-04-21 | 2010-04-30 | Shionogi & Co | Compuestos derivados de ciclohexil sulfonamidas que tienen actividad antagonista en el receptor npy y5, composicion farmaceutica y formulacion farmaceutica que los comprende. |
AR071719A1 (es) | 2008-05-13 | 2010-07-07 | Boehringer Ingelheim Int | Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion |
CN102105459B (zh) | 2008-07-24 | 2014-09-10 | 内尔维阿诺医学科学有限公司 | 作为蛋白激酶抑制剂的3,4-二芳基吡唑类 |
CA2735204C (en) * | 2008-08-25 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
JP2012506388A (ja) * | 2008-10-23 | 2012-03-15 | ロンザ リミテッド | 置換されたピラゾールの合成方法 |
EP2386546B1 (en) * | 2008-11-21 | 2015-08-19 | RaQualia Pharma Inc | Novel pyrazole-3-carboxamide derivate having 5-ht2b receptor antagonist activity |
JP5670440B2 (ja) | 2009-06-02 | 2015-02-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状阻害剤 |
US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
EA201200321A1 (ru) * | 2009-08-26 | 2012-09-28 | Новартис Аг | Тетразамещенные гетероарильные соединения и их применение в качестве модуляторов mdm2 и/или mdm4 |
JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
BR112012018358A2 (pt) | 2009-12-21 | 2016-08-09 | Bayer Cropscience Ag | tienilpiri(mi)dinilazol e seu uso para controlar fungos fitopatogênicos |
CN104958294A (zh) | 2010-01-27 | 2015-10-07 | 内尔维安诺医学科学有限公司 | 作为蛋白激酶抑制剂的3,4-二芳基吡唑的亚磺酰氨基衍生物 |
AR081810A1 (es) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | Piridinilpirazoles biciclicos |
WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
CN103153980B (zh) | 2010-08-03 | 2015-12-16 | 内尔维安诺医学科学有限公司 | 吡唑并苯基苯磺酰胺化合物的衍生物及其作为抗肿瘤药的用途 |
DK2654750T3 (en) * | 2010-12-20 | 2017-05-01 | Pfizer | HIS UNKNOWN CONDENSED PYRIDINE COMPOUNDS AS CASEIN-KINASE INHIBITORS |
AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
EP2744783A1 (en) | 2011-08-17 | 2014-06-25 | Boehringer Ingelheim International GmbH | Indenopyridine derivatives |
MX355016B (es) | 2011-10-06 | 2018-04-02 | Bayer Ip Gmbh | Heterociclilpiri(mi)dinilpirazoles como fungicidas. |
CN103958518B (zh) | 2011-10-06 | 2017-07-04 | 拜耳知识产权有限责任公司 | 杂环基吡啶基吡唑/杂环基嘧啶基吡唑 |
DE102011115525A1 (de) | 2011-10-11 | 2013-04-11 | Boehringer Ingelheim International Gmbh | Zweiteilige Flasche mit einem darin angeordneten Trockenmittel |
MX354725B (es) | 2011-11-11 | 2018-03-16 | Novartis Ag | Metodo de tratamiento de una enfermedad proliferativa. |
JP6216325B2 (ja) | 2011-11-23 | 2017-10-18 | ノバルティス アーゲー | 医薬製剤 |
US10500210B2 (en) | 2013-03-15 | 2019-12-10 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
US9573904B2 (en) * | 2013-12-12 | 2017-02-21 | Sumitomo Chemical Company, Limited | Aromatic compound and use thereof |
CN104829536B (zh) * | 2015-05-04 | 2017-12-29 | 陕西科技大学 | 一种具抗肿瘤活性的苯基吡唑羧酸类化合物及其合成方法 |
ES2791340T3 (es) * | 2015-05-27 | 2020-11-03 | Kyorin Seiyaku Kk | Derivado de urea o sal farmacológicamente aceptable del mismo |
CN112457255B (zh) * | 2017-11-08 | 2022-08-19 | 北京嘉林药业股份有限公司 | 化合物及其治疗癌症的用途 |
AU2019387370A1 (en) | 2018-11-30 | 2021-06-10 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
JP2023509452A (ja) | 2020-01-03 | 2023-03-08 | バーグ エルエルシー | がんを処置するためのube2kモジュレータとしての多環式アミド |
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US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
-
1998
- 1998-05-22 GE GEAP19985095A patent/GEP20033053B/en unknown
- 1998-05-22 EP EP98923642A patent/EP1000055A1/en not_active Withdrawn
- 1998-05-22 AP APAP/P/1999/001715A patent/AP1246A/en active
- 1998-05-22 CN CN98807369A patent/CN1264377A/zh active Pending
- 1998-05-22 WO PCT/US1998/010436 patent/WO1998052940A1/en not_active Application Discontinuation
- 1998-05-22 ID IDW991425A patent/ID22982A/id unknown
- 1998-05-22 JP JP55065098A patent/JP2002508754A/ja not_active Withdrawn
- 1998-05-22 ZA ZA984358A patent/ZA984358B/xx unknown
- 1998-05-22 EE EEP199900527A patent/EE9900527A/xx unknown
- 1998-05-22 TR TR2000/00235T patent/TR200000235T2/xx unknown
- 1998-05-22 CA CA002291115A patent/CA2291115A1/en not_active Abandoned
- 1998-05-22 KR KR19997010820A patent/KR20010012854A/ko not_active Application Discontinuation
- 1998-05-22 SK SK1578-99A patent/SK157899A3/sk unknown
- 1998-05-22 NZ NZ501112A patent/NZ501112A/xx unknown
- 1998-05-22 AU AU75883/98A patent/AU754830C/en not_active Ceased
- 1998-05-22 EA EA199900953A patent/EA003925B1/ru not_active IP Right Cessation
- 1998-05-22 IL IL13299198A patent/IL132991A/xx not_active IP Right Cessation
- 1998-05-22 BR BR9809147-6A patent/BR9809147A/pt not_active Application Discontinuation
- 1998-05-22 PL PL98337020A patent/PL337020A1/xx unknown
- 1998-05-22 HU HU0001880A patent/HUP0001880A3/hu unknown
-
1999
- 1999-11-19 NO NO995695A patent/NO995695L/no not_active Application Discontinuation
- 1999-11-19 IS IS5257A patent/IS5257A/is unknown
- 1999-11-22 OA OA9900252A patent/OA12981A/en unknown
- 1999-12-08 BG BG103964A patent/BG64313B1/bg unknown
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SK157899A3 (en) | 2000-08-14 |
HUP0001880A3 (en) | 2002-03-28 |
HUP0001880A2 (en) | 2001-03-28 |
AP1246A (en) | 2004-02-07 |
EA003925B1 (ru) | 2003-10-30 |
TR200000235T2 (tr) | 2000-05-22 |
GEP20033053B (en) | 2003-08-25 |
ZA984358B (en) | 1999-05-24 |
JP2002508754A (ja) | 2002-03-19 |
BR9809147A (pt) | 2000-08-01 |
AU754830B2 (en) | 2002-11-28 |
BG64313B1 (bg) | 2004-09-30 |
IL132991A0 (en) | 2001-03-19 |
EP1000055A1 (en) | 2000-05-17 |
NO995695L (no) | 2000-01-21 |
EE9900527A (et) | 2000-06-15 |
CN1264377A (zh) | 2000-08-23 |
AU754830C (en) | 2004-02-12 |
EA199900953A1 (ru) | 2000-10-30 |
NZ501112A (en) | 2002-10-25 |
NO995695D0 (no) | 1999-11-19 |
AP9901715A0 (en) | 1999-12-31 |
CA2291115A1 (en) | 1998-11-26 |
BG103964A (en) | 2000-08-31 |
IS5257A (is) | 1999-11-19 |
OA12981A (en) | 2006-10-13 |
PL337020A1 (en) | 2000-07-31 |
WO1998052940A1 (en) | 1998-11-26 |
IL132991A (en) | 2005-11-20 |
AU7588398A (en) | 1998-12-11 |
KR20010012854A (ko) | 2001-02-26 |
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