HUP0001880A2 - Substituted pyrazoles as p38 kinase inhibitors - Google Patents
Substituted pyrazoles as p38 kinase inhibitorsInfo
- Publication number
- HUP0001880A2 HUP0001880A2 HU0001880A HUP0001880A HUP0001880A2 HU P0001880 A2 HUP0001880 A2 HU P0001880A2 HU 0001880 A HU0001880 A HU 0001880A HU P0001880 A HUP0001880 A HU P0001880A HU P0001880 A2 HUP0001880 A2 HU P0001880A2
- Authority
- HU
- Hungary
- Prior art keywords
- kinase inhibitors
- substituted pyrazoles
- pyrazoles
- substituted
- kinase
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4757097P | 1997-05-22 | 1997-05-22 | |
| PCT/US1998/010436 WO1998052940A1 (en) | 1997-05-22 | 1998-05-22 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001880A2 true HUP0001880A2 (en) | 2001-03-28 |
| HUP0001880A3 HUP0001880A3 (en) | 2002-03-28 |
Family
ID=21949743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001880A HUP0001880A3 (en) | 1997-05-22 | 1998-05-22 | Substituted pyrazoles as p38 kinase inhibitors |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1000055A1 (en) |
| JP (1) | JP2002508754A (en) |
| KR (1) | KR20010012854A (en) |
| CN (1) | CN1264377A (en) |
| AP (1) | AP1246A (en) |
| AU (1) | AU754830C (en) |
| BG (1) | BG64313B1 (en) |
| BR (1) | BR9809147A (en) |
| CA (1) | CA2291115A1 (en) |
| EA (1) | EA003925B1 (en) |
| EE (1) | EE9900527A (en) |
| GE (1) | GEP20033053B (en) |
| HU (1) | HUP0001880A3 (en) |
| ID (1) | ID22982A (en) |
| IL (1) | IL132991A (en) |
| IS (1) | IS5257A (en) |
| NO (1) | NO995695L (en) |
| NZ (1) | NZ501112A (en) |
| OA (1) | OA12981A (en) |
| PL (1) | PL337020A1 (en) |
| SK (1) | SK157899A3 (en) |
| TR (1) | TR200000235T2 (en) |
| WO (1) | WO1998052940A1 (en) |
| ZA (1) | ZA984358B (en) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW289752B (en) * | 1994-03-11 | 1996-11-01 | Ciba Geigy Ag | |
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| CA2288787A1 (en) | 1997-05-22 | 1998-11-26 | G.D. Searle And Co. | Pyrazole derivatives as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| JP2002504909A (en) | 1997-06-13 | 2002-02-12 | スミスクライン・ビーチャム・コーポレイション | New substituted pyrazole and pyrazoline compounds |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| WO2000019824A1 (en) | 1998-10-07 | 2000-04-13 | Smithkline Beecham Corporation | Novel treatment for stroke management |
| DE69903976T2 (en) | 1998-12-16 | 2003-07-24 | Aventis Pharma Ltd | HETEROARYL CYCLIC ACETALS |
| US6191147B1 (en) | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
| ES2244231T3 (en) * | 1998-12-25 | 2005-12-01 | Teikoku Hormone Mfg. Co., Ltd. | DERIVATIVES OF AMINOPIRAZOL. |
| NZ514756A (en) | 1999-03-26 | 2004-04-30 | Euro Celtique S | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| WO2000075131A1 (en) * | 1999-06-03 | 2000-12-14 | Teikoku Hormone Mfg. Co., Ltd. | Substituted pyrazole compounds |
| US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
| AU6909600A (en) * | 1999-08-13 | 2001-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
| WO2001030154A2 (en) * | 1999-10-25 | 2001-05-03 | Basf Aktiengesellschaft | Agrochemical compositions containing pyrazoles and use thereof as fungicidal plant protection agents |
| DE19952147A1 (en) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | New cyclopropanes, pharmaceutical compositions containing these compounds and process for their preparation |
| DE60015599T2 (en) | 1999-11-23 | 2005-11-03 | Smithkline Beecham Corp. | 3,4-DIHYDRO- (1H) CHINAZOLIN-2-ON COMPOUNDS AS CSBP / p38 KINASE INHIBITORS |
| EP1309592B9 (en) | 2000-08-14 | 2007-02-28 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| EP1364949A4 (en) | 2001-02-02 | 2005-11-23 | Takeda Pharmaceutical | Jnk inhibitor |
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| ES2289116T3 (en) | 2001-05-24 | 2008-02-01 | Eli Lilly And Company | NEW DERIVATIVES OF PIRROL AS PHARMACEUTICAL AGENTS. |
| US7057049B2 (en) | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
| MXPA04002855A (en) | 2001-09-25 | 2004-07-05 | Pharmacia Corp | Process for making substituted pyrazoles. |
| MXPA04011638A (en) * | 2002-06-05 | 2005-03-07 | Pharmacia Corp | Pyrazole-derivatives as p38 kinase inhibitors. |
| EP1534282B1 (en) | 2002-07-09 | 2006-12-27 | Boehringer Ingelheim Pharma GmbH & Co.KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0217786D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
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| CA2515119A1 (en) | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
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| CA2643066A1 (en) * | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
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| CN104829536B (en) * | 2015-05-04 | 2017-12-29 | 陕西科技大学 | A kind of Phenylpyrazole carboxylic acid compound and its synthetic method for having antitumor activity |
| JP6746614B2 (en) * | 2015-05-27 | 2020-08-26 | 杏林製薬株式会社 | Urea derivative or its pharmacologically acceptable salt |
| CN112480079B (en) * | 2017-11-08 | 2022-03-11 | 北京嘉林药业股份有限公司 | Compounds and their use for treating cancer |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| US11091447B2 (en) | 2020-01-03 | 2021-08-17 | Berg Llc | UBE2K modulators and methods for their use |
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|---|---|---|---|---|
| US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
| US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
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1998
- 1998-05-22 AP APAP/P/1999/001715A patent/AP1246A/en active
- 1998-05-22 KR KR19997010820A patent/KR20010012854A/en not_active Application Discontinuation
- 1998-05-22 HU HU0001880A patent/HUP0001880A3/en unknown
- 1998-05-22 CN CN98807369A patent/CN1264377A/en active Pending
- 1998-05-22 IL IL13299198A patent/IL132991A/en not_active IP Right Cessation
- 1998-05-22 JP JP55065098A patent/JP2002508754A/en not_active Withdrawn
- 1998-05-22 EP EP98923642A patent/EP1000055A1/en not_active Withdrawn
- 1998-05-22 SK SK1578-99A patent/SK157899A3/en unknown
- 1998-05-22 NZ NZ501112A patent/NZ501112A/en unknown
- 1998-05-22 PL PL98337020A patent/PL337020A1/en unknown
- 1998-05-22 EA EA199900953A patent/EA003925B1/en not_active IP Right Cessation
- 1998-05-22 BR BR9809147-6A patent/BR9809147A/en not_active Application Discontinuation
- 1998-05-22 WO PCT/US1998/010436 patent/WO1998052940A1/en not_active Application Discontinuation
- 1998-05-22 ID IDW991425A patent/ID22982A/en unknown
- 1998-05-22 AU AU75883/98A patent/AU754830C/en not_active Ceased
- 1998-05-22 TR TR2000/00235T patent/TR200000235T2/en unknown
- 1998-05-22 EE EEP199900527A patent/EE9900527A/en unknown
- 1998-05-22 CA CA002291115A patent/CA2291115A1/en not_active Abandoned
- 1998-05-22 ZA ZA984358A patent/ZA984358B/en unknown
- 1998-05-22 GE GEAP19985095A patent/GEP20033053B/en unknown
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1999
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- 1999-11-19 IS IS5257A patent/IS5257A/en unknown
- 1999-11-22 OA OA9900252A patent/OA12981A/en unknown
- 1999-12-08 BG BG103964A patent/BG64313B1/en unknown
Also Published As
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| AU7588398A (en) | 1998-12-11 |
| IL132991A (en) | 2005-11-20 |
| EA003925B1 (en) | 2003-10-30 |
| ZA984358B (en) | 1999-05-24 |
| PL337020A1 (en) | 2000-07-31 |
| OA12981A (en) | 2006-10-13 |
| IL132991A0 (en) | 2001-03-19 |
| BR9809147A (en) | 2000-08-01 |
| EA199900953A1 (en) | 2000-10-30 |
| AU754830B2 (en) | 2002-11-28 |
| NO995695D0 (en) | 1999-11-19 |
| EE9900527A (en) | 2000-06-15 |
| AU754830C (en) | 2004-02-12 |
| JP2002508754A (en) | 2002-03-19 |
| EP1000055A1 (en) | 2000-05-17 |
| NZ501112A (en) | 2002-10-25 |
| CA2291115A1 (en) | 1998-11-26 |
| NO995695L (en) | 2000-01-21 |
| HUP0001880A3 (en) | 2002-03-28 |
| AP9901715A0 (en) | 1999-12-31 |
| BG64313B1 (en) | 2004-09-30 |
| AP1246A (en) | 2004-02-07 |
| BG103964A (en) | 2000-08-31 |
| ID22982A (en) | 1999-12-23 |
| WO1998052940A1 (en) | 1998-11-26 |
| TR200000235T2 (en) | 2000-05-22 |
| KR20010012854A (en) | 2001-02-26 |
| GEP20033053B (en) | 2003-08-25 |
| CN1264377A (en) | 2000-08-23 |
| SK157899A3 (en) | 2000-08-14 |
| IS5257A (en) | 1999-11-19 |
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| FD9A | Lapse of provisional protection due to non-payment of fees |