ID22982A - SUBSTITUTED PIRAZOLS AS KINASE INHIBITORS p38 - Google Patents
SUBSTITUTED PIRAZOLS AS KINASE INHIBITORS p38Info
- Publication number
- ID22982A ID22982A IDW991425A ID991425A ID22982A ID 22982 A ID22982 A ID 22982A ID W991425 A IDW991425 A ID W991425A ID 991425 A ID991425 A ID 991425A ID 22982 A ID22982 A ID 22982A
- Authority
- ID
- Indonesia
- Prior art keywords
- pirazols
- substituted
- kinase inhibitors
- kinase
- inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4757097P | 1997-05-22 | 1997-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID22982A true ID22982A (en) | 1999-12-23 |
Family
ID=21949743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW991425A ID22982A (en) | 1997-05-22 | 1998-05-22 | SUBSTITUTED PIRAZOLS AS KINASE INHIBITORS p38 |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1000055A1 (en) |
JP (1) | JP2002508754A (en) |
KR (1) | KR20010012854A (en) |
CN (1) | CN1264377A (en) |
AP (1) | AP1246A (en) |
AU (1) | AU754830C (en) |
BG (1) | BG64313B1 (en) |
BR (1) | BR9809147A (en) |
CA (1) | CA2291115A1 (en) |
EA (1) | EA003925B1 (en) |
EE (1) | EE9900527A (en) |
GE (1) | GEP20033053B (en) |
HU (1) | HUP0001880A3 (en) |
ID (1) | ID22982A (en) |
IL (1) | IL132991A (en) |
IS (1) | IS5257A (en) |
NO (1) | NO995695L (en) |
NZ (1) | NZ501112A (en) |
OA (1) | OA12981A (en) |
PL (1) | PL337020A1 (en) |
SK (1) | SK157899A3 (en) |
TR (1) | TR200000235T2 (en) |
WO (1) | WO1998052940A1 (en) |
ZA (1) | ZA984358B (en) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW289752B (en) * | 1994-03-11 | 1996-11-01 | Ciba Geigy Ag | |
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
AU7726898A (en) | 1997-05-22 | 1998-12-11 | G.D. Searle & Co. | Pyrazole derivatives as p38 kinase inhibitors |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
AU7966198A (en) | 1997-06-13 | 1998-12-30 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
US6649617B1 (en) | 1998-10-07 | 2003-11-18 | Smithkline Beecham Corporation | Treatment for stroke management |
WO2000035911A1 (en) | 1998-12-16 | 2000-06-22 | Aventis Pharma Limited | Heteroaryl-cyclic acetals |
US6191147B1 (en) | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
JP4632544B2 (en) * | 1998-12-25 | 2011-02-16 | あすか製薬株式会社 | Aminopyrazole derivatives |
AR023171A1 (en) | 1999-03-26 | 2002-09-04 | Cocensys Inc | PIRAZOLES, IMIDAZOLES, OXAZOLES, TIAZOLES, AND PIRROLES REPLACED BY ARILO, AND THE USE OF THEMSELVES. |
KR100697585B1 (en) | 1999-06-03 | 2007-03-22 | 아스카 세이야쿠 가부시키가이샤 | Substituted pyrazole compounds |
US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
MXPA02001565A (en) * | 1999-08-13 | 2005-07-14 | Vertex Pharma | INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES. |
WO2001030154A2 (en) * | 1999-10-25 | 2001-05-03 | Basf Aktiengesellschaft | Agrochemical compositions containing pyrazoles and use thereof as fungicidal plant protection agents |
DE19952147A1 (en) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | New cyclopropanes, pharmaceutical compositions containing these compounds and process for their preparation |
JP2003514899A (en) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | 3,4-Dihydro- (1H) -quinazolin-2-one compounds as CSBP / p38 kinase inhibitors |
MXPA03001420A (en) | 2000-08-14 | 2004-01-26 | Johnson & Johnson | Substituted pyrazoles. |
GB0102687D0 (en) | 2001-02-02 | 2001-03-21 | Pharmacia & Upjohn Spa | Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them |
CA2437248A1 (en) | 2001-02-02 | 2002-08-15 | Takeda Chemical Industries, Ltd. | Jnk inhibitor |
US7074801B1 (en) | 2001-04-26 | 2006-07-11 | Eisai Co., Ltd. | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof |
DE60221392T2 (en) | 2001-05-24 | 2008-04-17 | Eli Lilly And Co., Indianapolis | NEW PYROL DERIVATIVES AS PHARMACEUTICAL AGENTS |
US7057049B2 (en) | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
CN1321644C (en) | 2001-09-25 | 2007-06-20 | 法玛西雅公司 | Process for making substituted pyrazoles |
CA2488402A1 (en) * | 2002-06-05 | 2003-12-18 | Pharmacia Corporation | Pyrazole-derivatives as p38 kinase inhibitors |
GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
ES2278170T3 (en) | 2002-07-09 | 2007-08-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | PHARMACEUTICAL COMPOSITIONS OF ANTICOLINERGIC AND INHIBITORS OF QUINASE P38 IN THE TREATMENT OF RESPIRATORY DISEASES. |
GB0217786D0 (en) * | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
US7166619B2 (en) | 2002-08-14 | 2007-01-23 | Ppd Discovery , Inc. | Prenylation inhibitors and methods of their synthesis and use |
US6649638B1 (en) | 2002-08-14 | 2003-11-18 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
WO2004026302A1 (en) * | 2002-09-19 | 2004-04-01 | Eli Lilly And Company | Methods of inhibiting tgf beta with substituted pyrazoles |
GB0229618D0 (en) | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
CA2515119A1 (en) | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
DK1778686T3 (en) | 2004-08-12 | 2009-01-12 | Pfizer | Triazolopyridinylsulfanyl derivatives as P38 MAP kinase inhibitors |
PE20060777A1 (en) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES |
JP5100126B2 (en) | 2004-12-28 | 2012-12-19 | あすか製薬株式会社 | Pyrimidinyl isoxazole derivatives |
JP2009530261A (en) * | 2006-03-16 | 2009-08-27 | ファイザー・プロダクツ・インク | Pyrazole compounds |
US8207203B2 (en) | 2006-06-28 | 2012-06-26 | Aska Pharmaceutical Co., Ltd. | Pyridylisoxazole derivatives |
US20090192164A1 (en) * | 2006-06-28 | 2009-07-30 | Aska Pharmaceutical Co., Ltd. | Treating agent of inflammatory bowel disease |
KR101434706B1 (en) | 2007-02-16 | 2014-08-26 | 아스카 세이야쿠 가부시키가이샤 | Pharmaceutical composition containing fine particle oil-based suspension |
EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
US20100144756A1 (en) * | 2007-07-13 | 2010-06-10 | Bolea Christelle | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
CL2008003407A1 (en) | 2007-11-16 | 2010-01-11 | Boehringer Ingelheim Int | Substituted heterobicyclo aryl- and heteroarylcarbonyl derivative compounds; pharmaceutical composition; preparation procedure; and its use in the treatment and / or prevention of metabolic disorders, mediated by the inhibition of the enzyme hsd-1. |
CL2009000904A1 (en) | 2008-04-21 | 2010-04-30 | Shionogi & Co | Compounds derived from cyclohexyl sulfonamides having antagonist activity at the npy y5 receptor, pharmaceutical composition and pharmaceutical formulation comprising them. |
CL2009001151A1 (en) | 2008-05-13 | 2010-08-13 | Boehringer Ingelheim Int | Compounds derived from benzomorphane alicyclic carbocyclic acids, preparation procedure, pharmaceutical composition, useful for treating diseases influenced by the inhibition of the enzyme 11beta-hydroxysteroid dehydrogenase, such as metabolic disorders. |
CN102105459B (en) | 2008-07-24 | 2014-09-10 | 内尔维阿诺医学科学有限公司 | 3,4-diarylpyrazoles as protein kinase inhibitors |
WO2010023161A1 (en) * | 2008-08-25 | 2010-03-04 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
JP2012506388A (en) * | 2008-10-23 | 2012-03-15 | ロンザ リミテッド | Method for the synthesis of substituted pyrazoles |
WO2010058858A1 (en) * | 2008-11-21 | 2010-05-27 | ラクオリア創薬株式会社 | Novel pyrazole-3-carboxamide derivative having 5-ht2b receptor antagonist activity |
EP2438049B1 (en) | 2009-06-02 | 2014-05-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
WO2011023677A1 (en) * | 2009-08-26 | 2011-03-03 | Novartis Ag | Tetra-substituted heteroaryl compounds and their use as mdm2 and/or mdm4 modulators |
JO3002B1 (en) | 2009-08-28 | 2016-09-05 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
EP2308866A1 (en) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazoles and their use as fungicides |
AR079545A1 (en) | 2009-12-21 | 2012-02-01 | Bayer Cropscience Ag | TIENILPIRI (MI) DINILAZOL |
JP5806239B2 (en) | 2010-01-27 | 2015-11-10 | ネルヴィアーノ・メディカル・サイエンシズ・ソチエタ・ア・レスポンサビリタ・リミタータ | Sulfonamide derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors |
AR081810A1 (en) | 2010-04-07 | 2012-10-24 | Bayer Cropscience Ag | BICYCLE PIRIDINYL PIRAZOLS |
EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
WO2012016993A1 (en) | 2010-08-03 | 2012-02-09 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
DK2654750T3 (en) * | 2010-12-20 | 2017-05-01 | Pfizer | HIS UNKNOWN CONDENSED PYRIDINE COMPOUNDS AS CASEIN-KINASE INHIBITORS |
WO2012175513A1 (en) | 2011-06-20 | 2012-12-27 | Bayer Intellectual Property Gmbh | Thienylpyri(mi)dinylpyrazole |
WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
AU2012320581B2 (en) | 2011-10-06 | 2017-03-30 | Bayer Intellectual Property Gmbh | Heterocyclylpyri (mi) dinylpyrazole as fungicidals |
US9314026B2 (en) | 2011-10-06 | 2016-04-19 | Bayer Intellectual Property Gmbh | Heterocyclylpyri(mi)dinylpyrazole |
DE102011115525A1 (en) | 2011-10-11 | 2013-04-11 | Boehringer Ingelheim International Gmbh | Two-part bottle packaging device for containing pharmaceutical tablets or capsules, has bottle body and bottle base, where bottle is closed with pressure lock or with pressure lock injected at bottle body or with separate rotary lock |
CA2855243C (en) | 2011-11-11 | 2020-04-14 | Novartis Ag | Method of treating a proliferative disease |
MY172729A (en) | 2011-11-23 | 2019-12-11 | Array Biopharma Inc | Pharmaceutical formulations |
ES2900815T3 (en) | 2013-03-15 | 2022-03-18 | Scripps Research Inst | Compounds and methods for inducing chondrogenesis |
WO2015088038A1 (en) * | 2013-12-12 | 2015-06-18 | 住友化学株式会社 | Aromatic compound and application for same |
CN104829536B (en) * | 2015-05-04 | 2017-12-29 | 陕西科技大学 | A kind of Phenylpyrazole carboxylic acid compound and its synthetic method for having antitumor activity |
ES2791340T3 (en) * | 2015-05-27 | 2020-11-03 | Kyorin Seiyaku Kk | Derived from urea or pharmacologically acceptable salt thereof |
CN112480005B (en) * | 2017-11-08 | 2022-08-19 | 北京嘉林药业股份有限公司 | Compounds and their use for treating cancer |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
US11091447B2 (en) | 2020-01-03 | 2021-08-17 | Berg Llc | UBE2K modulators and methods for their use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
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1998
- 1998-05-22 EP EP98923642A patent/EP1000055A1/en not_active Withdrawn
- 1998-05-22 GE GEAP19985095A patent/GEP20033053B/en unknown
- 1998-05-22 CN CN98807369A patent/CN1264377A/en active Pending
- 1998-05-22 AU AU75883/98A patent/AU754830C/en not_active Ceased
- 1998-05-22 ZA ZA984358A patent/ZA984358B/en unknown
- 1998-05-22 JP JP55065098A patent/JP2002508754A/en not_active Withdrawn
- 1998-05-22 EA EA199900953A patent/EA003925B1/en not_active IP Right Cessation
- 1998-05-22 SK SK1578-99A patent/SK157899A3/en unknown
- 1998-05-22 TR TR2000/00235T patent/TR200000235T2/en unknown
- 1998-05-22 NZ NZ501112A patent/NZ501112A/en unknown
- 1998-05-22 WO PCT/US1998/010436 patent/WO1998052940A1/en not_active Application Discontinuation
- 1998-05-22 ID IDW991425A patent/ID22982A/en unknown
- 1998-05-22 PL PL98337020A patent/PL337020A1/en unknown
- 1998-05-22 EE EEP199900527A patent/EE9900527A/en unknown
- 1998-05-22 KR KR19997010820A patent/KR20010012854A/en not_active Application Discontinuation
- 1998-05-22 HU HU0001880A patent/HUP0001880A3/en unknown
- 1998-05-22 CA CA002291115A patent/CA2291115A1/en not_active Abandoned
- 1998-05-22 BR BR9809147-6A patent/BR9809147A/en not_active Application Discontinuation
- 1998-05-22 AP APAP/P/1999/001715A patent/AP1246A/en active
- 1998-05-22 IL IL13299198A patent/IL132991A/en not_active IP Right Cessation
-
1999
- 1999-11-19 IS IS5257A patent/IS5257A/en unknown
- 1999-11-19 NO NO995695A patent/NO995695L/en not_active Application Discontinuation
- 1999-11-22 OA OA9900252A patent/OA12981A/en unknown
- 1999-12-08 BG BG103964A patent/BG64313B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL337020A1 (en) | 2000-07-31 |
OA12981A (en) | 2006-10-13 |
AP9901715A0 (en) | 1999-12-31 |
TR200000235T2 (en) | 2000-05-22 |
JP2002508754A (en) | 2002-03-19 |
AU7588398A (en) | 1998-12-11 |
IS5257A (en) | 1999-11-19 |
AU754830B2 (en) | 2002-11-28 |
WO1998052940A1 (en) | 1998-11-26 |
EP1000055A1 (en) | 2000-05-17 |
HUP0001880A3 (en) | 2002-03-28 |
GEP20033053B (en) | 2003-08-25 |
BG64313B1 (en) | 2004-09-30 |
NO995695L (en) | 2000-01-21 |
AU754830C (en) | 2004-02-12 |
CA2291115A1 (en) | 1998-11-26 |
SK157899A3 (en) | 2000-08-14 |
BG103964A (en) | 2000-08-31 |
EE9900527A (en) | 2000-06-15 |
IL132991A (en) | 2005-11-20 |
IL132991A0 (en) | 2001-03-19 |
ZA984358B (en) | 1999-05-24 |
AP1246A (en) | 2004-02-07 |
HUP0001880A2 (en) | 2001-03-28 |
BR9809147A (en) | 2000-08-01 |
NO995695D0 (en) | 1999-11-19 |
KR20010012854A (en) | 2001-02-26 |
EA003925B1 (en) | 2003-10-30 |
CN1264377A (en) | 2000-08-23 |
NZ501112A (en) | 2002-10-25 |
EA199900953A1 (en) | 2000-10-30 |
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