IL132991A0 - Substituted pyrazoles as p38 kinase inhibitors - Google Patents
Substituted pyrazoles as p38 kinase inhibitorsInfo
- Publication number
- IL132991A0 IL132991A0 IL13299198A IL13299198A IL132991A0 IL 132991 A0 IL132991 A0 IL 132991A0 IL 13299198 A IL13299198 A IL 13299198A IL 13299198 A IL13299198 A IL 13299198A IL 132991 A0 IL132991 A0 IL 132991A0
- Authority
- IL
- Israel
- Prior art keywords
- kinase inhibitors
- substituted pyrazoles
- pyrazoles
- substituted
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4757097P | 1997-05-22 | 1997-05-22 | |
PCT/US1998/010436 WO1998052940A1 (en) | 1997-05-22 | 1998-05-22 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
Publications (2)
Publication Number | Publication Date |
---|---|
IL132991A0 true IL132991A0 (en) | 2001-03-19 |
IL132991A IL132991A (en) | 2005-11-20 |
Family
ID=21949743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13299198A IL132991A (en) | 1997-05-22 | 1998-05-22 | Substituted pyrazoles, pharmaceutical compositionscomprising them and their use as p38 inase inhibi tors |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1000055A1 (en) |
JP (1) | JP2002508754A (en) |
KR (1) | KR20010012854A (en) |
CN (1) | CN1264377A (en) |
AP (1) | AP1246A (en) |
AU (1) | AU754830C (en) |
BG (1) | BG64313B1 (en) |
BR (1) | BR9809147A (en) |
CA (1) | CA2291115A1 (en) |
EA (1) | EA003925B1 (en) |
EE (1) | EE9900527A (en) |
GE (1) | GEP20033053B (en) |
HU (1) | HUP0001880A3 (en) |
ID (1) | ID22982A (en) |
IL (1) | IL132991A (en) |
IS (1) | IS5257A (en) |
NO (1) | NO995695L (en) |
NZ (1) | NZ501112A (en) |
OA (1) | OA12981A (en) |
PL (1) | PL337020A1 (en) |
SK (1) | SK157899A3 (en) |
TR (1) | TR200000235T2 (en) |
WO (1) | WO1998052940A1 (en) |
ZA (1) | ZA984358B (en) |
Families Citing this family (77)
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TW289752B (en) * | 1994-03-11 | 1996-11-01 | Ciba Geigy Ag | |
US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
US6087381A (en) | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
WO1998056377A1 (en) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
EP1119254A4 (en) | 1998-10-07 | 2004-05-12 | Smithkline Beecham Corp | Novel treatment for stroke management |
JP4634613B2 (en) | 1998-12-16 | 2011-02-16 | アベンティス・フアーマ・リミテッド | Heteroaryl cyclic acetals |
US6191147B1 (en) | 1998-12-24 | 2001-02-20 | Ppd Discovery, Inc. | Pyrazole compounds and uses thereof |
JP4632544B2 (en) * | 1998-12-25 | 2011-02-16 | あすか製薬株式会社 | Aminopyrazole derivatives |
DE60044395D1 (en) | 1999-03-26 | 2010-06-24 | Euro Celtique Sa | ARYLSUBSTITUTED PYRAZOLE, IMIDAZOLE, OXAZOLE, THIAZOLE AND PYRROLE, AND THEIR USE |
US6667325B1 (en) | 1999-06-03 | 2003-12-23 | Teikoku Hormone Mfg. Co., Ltd. | Substituted pyrazole compounds |
US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
EP1218369B1 (en) * | 1999-08-13 | 2008-07-23 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES |
WO2001030154A2 (en) * | 1999-10-25 | 2001-05-03 | Basf Aktiengesellschaft | Agrochemical compositions containing pyrazoles and use thereof as fungicidal plant protection agents |
DE19952147A1 (en) | 1999-10-29 | 2001-05-03 | Boehringer Ingelheim Pharma | New cyclopropanes, pharmaceutical compositions containing these compounds and process for their preparation |
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JP2005538958A (en) * | 2002-06-05 | 2005-12-22 | ファルマシア・コーポレーション | Pyrazole derivatives as p38 kinase inhibitors |
GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
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US7166619B2 (en) | 2002-08-14 | 2007-01-23 | Ppd Discovery , Inc. | Prenylation inhibitors and methods of their synthesis and use |
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CN107848962B (en) * | 2015-05-27 | 2021-04-09 | 杏林制药株式会社 | Urea derivative or pharmacologically acceptable salt thereof |
CN112480079B (en) * | 2017-11-08 | 2022-03-11 | 北京嘉林药业股份有限公司 | Compounds and their use for treating cancer |
EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
AU2020417293A1 (en) | 2020-01-03 | 2022-09-01 | Berg Llc | Polycyclic amides as UBE2K modulators for treating cancer |
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US5559137A (en) * | 1994-05-16 | 1996-09-24 | Smithkline Beecham Corp. | Compounds |
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
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1998
- 1998-05-22 JP JP55065098A patent/JP2002508754A/en not_active Withdrawn
- 1998-05-22 CA CA002291115A patent/CA2291115A1/en not_active Abandoned
- 1998-05-22 GE GEAP19985095A patent/GEP20033053B/en unknown
- 1998-05-22 AU AU75883/98A patent/AU754830C/en not_active Ceased
- 1998-05-22 IL IL13299198A patent/IL132991A/en not_active IP Right Cessation
- 1998-05-22 PL PL98337020A patent/PL337020A1/en unknown
- 1998-05-22 AP APAP/P/1999/001715A patent/AP1246A/en active
- 1998-05-22 EA EA199900953A patent/EA003925B1/en not_active IP Right Cessation
- 1998-05-22 ID IDW991425A patent/ID22982A/en unknown
- 1998-05-22 SK SK1578-99A patent/SK157899A3/en unknown
- 1998-05-22 WO PCT/US1998/010436 patent/WO1998052940A1/en not_active Application Discontinuation
- 1998-05-22 TR TR2000/00235T patent/TR200000235T2/en unknown
- 1998-05-22 HU HU0001880A patent/HUP0001880A3/en unknown
- 1998-05-22 ZA ZA984358A patent/ZA984358B/en unknown
- 1998-05-22 EE EEP199900527A patent/EE9900527A/en unknown
- 1998-05-22 BR BR9809147-6A patent/BR9809147A/en not_active Application Discontinuation
- 1998-05-22 CN CN98807369A patent/CN1264377A/en active Pending
- 1998-05-22 EP EP98923642A patent/EP1000055A1/en not_active Withdrawn
- 1998-05-22 NZ NZ501112A patent/NZ501112A/en unknown
- 1998-05-22 KR KR19997010820A patent/KR20010012854A/en not_active Application Discontinuation
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1999
- 1999-11-19 IS IS5257A patent/IS5257A/en unknown
- 1999-11-19 NO NO995695A patent/NO995695L/en not_active Application Discontinuation
- 1999-11-22 OA OA9900252A patent/OA12981A/en unknown
- 1999-12-08 BG BG103964A patent/BG64313B1/en unknown
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CA2291115A1 (en) | 1998-11-26 |
BG103964A (en) | 2000-08-31 |
PL337020A1 (en) | 2000-07-31 |
WO1998052940A1 (en) | 1998-11-26 |
NZ501112A (en) | 2002-10-25 |
ID22982A (en) | 1999-12-23 |
EE9900527A (en) | 2000-06-15 |
BG64313B1 (en) | 2004-09-30 |
EA199900953A1 (en) | 2000-10-30 |
AP9901715A0 (en) | 1999-12-31 |
KR20010012854A (en) | 2001-02-26 |
IL132991A (en) | 2005-11-20 |
NO995695D0 (en) | 1999-11-19 |
AU754830B2 (en) | 2002-11-28 |
OA12981A (en) | 2006-10-13 |
BR9809147A (en) | 2000-08-01 |
AU7588398A (en) | 1998-12-11 |
JP2002508754A (en) | 2002-03-19 |
ZA984358B (en) | 1999-05-24 |
HUP0001880A2 (en) | 2001-03-28 |
SK157899A3 (en) | 2000-08-14 |
HUP0001880A3 (en) | 2002-03-28 |
EA003925B1 (en) | 2003-10-30 |
NO995695L (en) | 2000-01-21 |
EP1000055A1 (en) | 2000-05-17 |
TR200000235T2 (en) | 2000-05-22 |
AP1246A (en) | 2004-02-07 |
AU754830C (en) | 2004-02-12 |
GEP20033053B (en) | 2003-08-25 |
CN1264377A (en) | 2000-08-23 |
IS5257A (en) | 1999-11-19 |
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