HUT72712A - Purification of factor vii - Google Patents

Purification of factor vii Download PDF

Info

Publication number
HUT72712A
HUT72712A HU9502846A HU9502846A HUT72712A HU T72712 A HUT72712 A HU T72712A HU 9502846 A HU9502846 A HU 9502846A HU 9502846 A HU9502846 A HU 9502846A HU T72712 A HUT72712 A HU T72712A
Authority
HU
Hungary
Prior art keywords
buffer
fvii
purification
nacl
activation
Prior art date
Application number
HU9502846A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9502846D0 (en
Inventor
Tony Jorgensen
Anders H Pedersen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of HU9502846D0 publication Critical patent/HU9502846D0/hu
Publication of HUT72712A publication Critical patent/HUT72712A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
HU9502846A 1993-03-31 1994-03-24 Purification of factor vii HUT72712A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK93382A DK38293D0 (da) 1993-03-31 1993-03-31 Fremstilling af proteiner

Publications (2)

Publication Number Publication Date
HU9502846D0 HU9502846D0 (en) 1995-12-28
HUT72712A true HUT72712A (en) 1996-05-28

Family

ID=8092871

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9502846A HUT72712A (en) 1993-03-31 1994-03-24 Purification of factor vii

Country Status (16)

Country Link
US (1) US5700914A (2)
EP (1) EP0691984A1 (2)
JP (1) JPH08508264A (2)
CN (1) CN1039231C (2)
AU (1) AU677309B2 (2)
CA (1) CA2159313A1 (2)
CZ (1) CZ253395A3 (2)
DK (1) DK38293D0 (2)
FI (1) FI954649A7 (2)
HU (1) HUT72712A (2)
IL (1) IL109164A0 (2)
NO (1) NO953883L (2)
PL (1) PL310887A1 (2)
TW (1) TW278079B (2)
WO (1) WO1994022905A1 (2)
ZA (1) ZA941956B (2)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19538716A1 (de) * 1995-10-18 1997-04-24 Behringwerke Ag Verfahren zur Quantifizierung von aktiviertem Gerinnungsfaktor VII (FVIIa)
DE19538715A1 (de) * 1995-10-18 1997-04-30 Behringwerke Ag Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII
CN1260249C (zh) 1998-05-06 2006-06-21 基因技术股份有限公司 用离子交换层析纯化蛋白质
AT408613B (de) * 1998-06-17 2002-01-25 Immuno Ag Pharmazeutisches faktor vii-präparat
CN100488562C (zh) 2000-02-11 2009-05-20 拜耳医药保健有限公司 凝血因子VⅡ或VⅡa样分子
ES2325653T3 (es) 2001-12-21 2009-09-11 Novo Nordisk Health Care Ag Composicion liquida de polipeptidos del factor vii.
US20040009918A1 (en) * 2002-05-03 2004-01-15 Hanne Nedergaard Stabilised solid compositions of modified factor VII
DK1517698T4 (da) * 2002-06-21 2018-01-29 Novo Nordisk Healthcare Ag Stabiliserede faste sammensætninger af Faktor VIIa-polypeptider
BRPI0408417A (pt) * 2003-03-18 2006-03-21 Novo Nordisk Healthcare Ag métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição
US7897734B2 (en) 2003-03-26 2011-03-01 Novo Nordisk Healthcare Ag Method for the production of proteins
KR20060015574A (ko) * 2003-05-23 2006-02-17 노보 노르디스크 헬스 케어 악티엔게젤샤프트 용액 중 단백질 안정화
WO2004112828A1 (en) * 2003-06-25 2004-12-29 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
JP5306597B2 (ja) * 2003-07-01 2013-10-02 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第ｖｉｉ因子ポリペプチドの液体水性薬学的組成物
RU2388460C2 (ru) 2003-08-14 2010-05-10 Ново Нордиск Хелс Кеа Аг Жидкая водная фармацевтическая композиция, содержащая полипептид фактора vii
ES2507091T3 (es) 2003-12-01 2014-10-14 Novo Nordisk Health Care Ag Nanofiltración de soluciones del factor VII para eliminar virus
KR20140093711A (ko) * 2003-12-19 2014-07-28 노보 노르디스크 헬스 케어 악티엔게젤샤프트 인자 ｖｉｉ 폴리펩티드의 안정화된 조성물
AU2005318106B2 (en) * 2004-12-23 2011-11-03 Novo Nordisk Health Care Ag Reduction of the content of protein contaminants in compositions comprising a Vitamin K-dependent protein of interest
US20090047723A1 (en) * 2005-01-14 2009-02-19 Bayer Healthcare Llc Method for purification of factor vii
EP1907540B1 (en) * 2005-07-22 2012-12-19 Bayer HealthCare LLC In-solution activation of factor vii
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
CN101384272B (zh) * 2005-12-20 2013-05-01 杜克大学 用于递送具有增强的药理性质的活性剂的方法和组合物
US8178495B2 (en) 2008-06-27 2012-05-15 Duke University Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide
CN103539852B (zh) * 2012-07-12 2015-08-12 上海泰龙生物医药科技有限公司 一种从细胞培养液中分离纯化重组人凝血八因子的方法
EP2687595B1 (en) * 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Method for purifying transgenic factor VII
US10285915B2 (en) 2012-10-17 2019-05-14 The Procter & Gamble Company Strip for the delivery of an oral care active and methods for applying oral care actives
AU2017381677B2 (en) * 2016-12-22 2019-10-03 Km Biologics Co., Ltd. Chromatographic method for collecting blood coagulation factor VII with high yield

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins

Also Published As

Publication number Publication date
TW278079B (2) 1996-06-11
FI954649A0 (fi) 1995-09-29
CZ253395A3 (en) 1996-01-17
WO1994022905A1 (en) 1994-10-13
PL310887A1 (en) 1996-01-08
AU677309B2 (en) 1997-04-17
ZA941956B (en) 1994-09-30
NO953883D0 (no) 1995-09-29
FI954649L (fi) 1995-09-29
NO953883L (no) 1995-11-28
CN1039231C (zh) 1998-07-22
US5700914A (en) 1997-12-23
CA2159313A1 (en) 1994-10-13
EP0691984A1 (en) 1996-01-17
IL109164A0 (en) 1994-06-24
CN1121723A (zh) 1996-05-01
FI954649A7 (fi) 1995-09-29
JPH08508264A (ja) 1996-09-03
HU9502846D0 (en) 1995-12-28
AU6423994A (en) 1994-10-24
DK38293D0 (da) 1993-03-31

Similar Documents

Publication Publication Date Title
HUT72712A (en) Purification of factor vii
JP3459416B2 (ja) 修飾されたファクター▲ｖｉｉ▼
US5580560A (en) Modified factor VII/VIIa
AT405516B (de) Faktor x-analoge mit modifizierter proteasespaltstelle
EP2504349B1 (en) Method of purifying pegylated proteins
AU2008209986B2 (en) FVIII-independent FIX-mutant proteins for hemophilia A treatment
AU732953B2 (en) Factor X deletion mutants and analogues thereof
KR20110036071A (ko) 그의 보조인자의 부존재하에서 응고활성을 갖는 인자 ｉｘ 변이체 및 출혈 질환을 치료하기 위한 그의 용도
KR100457984B1 (ko) 인자 vii 및 활성화된 인자 vii의 정제방법
Chavin Factor VIII: structure and function in blood clotting
CA2105282C (en) Preparation of factor ix
RU2167936C2 (ru) Способ минимизации деградации активированного протеина с (варианты), стабилизированная композиция активированного протеина с
JP4680329B2 (ja) 血管障害の治療方法
Rezaie et al. Proline at the P2 position in protein C is important for calcium-mediated regulation of protein C activation and secretion
AU703760B2 (en) Modified Factor VII pharmaceutical
CZ2000982A3 (cs) Farmaceutický preparát obsahující jednotlivé faktory, závislé na vitaminu K a jeho použití

Legal Events

Date Code Title Description
DFD9 Temporary protection cancelled due to non-payment of fee