HUT70742A - Trisubstituted tetrahydrofuran derivatives and antifungal compositions containing them as active components - Google Patents
Trisubstituted tetrahydrofuran derivatives and antifungal compositions containing them as active componentsInfo
- Publication number
- HUT70742A HUT70742A HU9401256A HU9401256A HUT70742A HU T70742 A HUT70742 A HU T70742A HU 9401256 A HU9401256 A HU 9401256A HU 9401256 A HU9401256 A HU 9401256A HU T70742 A HUT70742 A HU T70742A
- Authority
- HU
- Hungary
- Prior art keywords
- compositions containing
- active components
- tetrahydrofuran derivatives
- antifungal compositions
- chem
- Prior art date
Links
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title 1
- 239000012871 anti-fungal composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78535791A | 1991-10-30 | 1991-10-30 | |
| US90726292A | 1992-07-01 | 1992-07-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9401256D0 HU9401256D0 (en) | 1994-08-29 |
| HUT70742A true HUT70742A (en) | 1995-10-30 |
Family
ID=27120397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9401256A HUT70742A (en) | 1991-10-30 | 1992-10-28 | Trisubstituted tetrahydrofuran derivatives and antifungal compositions containing them as active components |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP0610377B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP3210017B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN1037267C (cg-RX-API-DMAC10.html) |
| AT (1) | ATE198888T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU665218B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2122270C (cg-RX-API-DMAC10.html) |
| CZ (1) | CZ102794A3 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69231661T2 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2153364T3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI941986A0 (cg-RX-API-DMAC10.html) |
| HR (1) | HRP921145A2 (cg-RX-API-DMAC10.html) |
| HU (1) | HUT70742A (cg-RX-API-DMAC10.html) |
| IL (1) | IL103558A0 (cg-RX-API-DMAC10.html) |
| MX (1) | MX9206222A (cg-RX-API-DMAC10.html) |
| MY (1) | MY109529A (cg-RX-API-DMAC10.html) |
| NO (1) | NO941589L (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ244910A (cg-RX-API-DMAC10.html) |
| SG (1) | SG42920A1 (cg-RX-API-DMAC10.html) |
| SI (1) | SI9200285A (cg-RX-API-DMAC10.html) |
| SK (1) | SK48894A3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO1993009114A1 (cg-RX-API-DMAC10.html) |
| YU (1) | YU94792A (cg-RX-API-DMAC10.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5349099A (en) * | 1993-12-13 | 1994-09-20 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| DE69428125T2 (de) * | 1993-12-21 | 2002-05-02 | Schering Corp., Kenilworth | Fungizide tetrahydrofurane |
| US5693626A (en) * | 1993-12-21 | 1997-12-02 | Schering Corporation | Tetrahydrofuran antifungals |
| US5661151A (en) * | 1993-12-21 | 1997-08-26 | Schering Corporation | Tetrahydrofuran antifungals |
| US5703236A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| US5714490A (en) * | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| US5710154A (en) * | 1993-12-21 | 1998-01-20 | Schering Corporation | Tetrahydrofuran antifungals |
| US5703079A (en) * | 1993-12-21 | 1997-12-30 | Schering Corporation | Tetrahydrofuran antifungals |
| JP3764750B2 (ja) * | 1994-01-24 | 2006-04-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 水溶性アゾール抗真菌剤 |
| CN1126987A (zh) * | 1994-04-19 | 1996-07-17 | 钟渊化学工业株式会社 | 三唑衍生物的制造方法 |
| US5442093A (en) * | 1994-05-09 | 1995-08-15 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| US5486625A (en) * | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| EP0725146A4 (en) * | 1994-07-18 | 1998-12-23 | Daicel Chem | METHOD FOR PRODUCING OPTICALLY ACTIVE TRIAZOLE COMPOUNDS AND METHOD FOR RAZEMIZING OPTICALLY ACTIVE TRIAZOLE COMPOUNDS |
| US5616777A (en) * | 1995-04-19 | 1997-04-01 | Schering Corporation | Chiral hydrazine derivatives |
| US5625064A (en) * | 1995-04-19 | 1997-04-29 | Schering Corporation | Process for the preparation of triazolones |
| MX9701229A (es) * | 1995-06-02 | 1997-05-31 | Schering Corp | Antifungicos de tetrahidrofurano. |
| US5698557A (en) * | 1995-06-19 | 1997-12-16 | Schering Corporation | Hydroxy-substituted antifungals |
| EP0837859B1 (en) * | 1995-06-19 | 2003-08-13 | Schering Corporation | Tetrahydrofuran antifungals |
| US5834472A (en) * | 1996-05-24 | 1998-11-10 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| US5846971A (en) * | 1996-06-28 | 1998-12-08 | Schering Corporation | Oral antifungal composition |
| TW593312B (en) * | 1997-07-11 | 2004-06-21 | Janssen Pharmaceutica Nv | 2,4,4-trisubstituted-1,3-dioxolane antifungals |
| HU225233B1 (en) * | 1997-10-07 | 2006-08-28 | Schering Corp | Crystalline polymorph of antifungal triazole derivative, pharmaceuticals containing the same and its use |
| AU2002253440A1 (en) * | 2002-04-12 | 2003-10-27 | Ranbaxy Laboratories Limited | Derivatives of 2,2,4-trisubstituted tetrahydrofuran as antifungal agents |
| RU2580318C2 (ru) | 2010-05-19 | 2016-04-10 | Сандоз Аг | Получение промежуточных продуктов для синтеза позаконазола |
| AU2011254658B2 (en) | 2010-05-19 | 2016-02-18 | Sandoz Ag | Purification of posaconazole and of posaconazole intermediates |
| JP5956980B2 (ja) | 2010-05-19 | 2016-07-27 | サンド・アクチエンゲゼルシヤフト | キラル化合物の調製の方法 |
| WO2011144653A1 (en) | 2010-05-19 | 2011-11-24 | Sandoz Ag | Process for the preparation of chiral triazolones |
| US9493428B2 (en) | 2011-06-16 | 2016-11-15 | Sandoz Ag | Process for the preparation of a chiral compound |
| DK3003038T3 (da) * | 2013-06-07 | 2019-11-11 | Scripps Research Inst | 2h-1,2,3-triazolderivater som inhibitorer af fibrose |
| CN106397417A (zh) * | 2016-08-30 | 2017-02-15 | 甘肃皓天化学科技有限公司 | 用于制备泊沙康唑的中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| DE3346123A1 (de) | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| DK354185A (da) * | 1984-08-31 | 1986-03-01 | Hoffmann La Roche | 1,3-dioxolanderivater |
| NZ223799A (en) * | 1987-03-25 | 1989-12-21 | Janssen Pharmaceutica Nv | Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions |
| US5006513A (en) | 1987-11-09 | 1991-04-09 | Miles Inc. | Antimycotic compositions of nikkomycin compounds and azole antimycotica |
| DE3852477T2 (de) * | 1987-11-20 | 1995-05-04 | Schering Corp | Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte. |
| US5002935A (en) | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| CA1331757C (en) * | 1988-02-29 | 1994-08-30 | Janssen Pharmaceutica Naamloze Vennootschap | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols |
| NZ233502A (en) * | 1989-06-09 | 1991-11-26 | Janssen Pharmaceutica Nv | 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US20040220100A1 (en) | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
-
1992
- 1992-10-27 IL IL103558A patent/IL103558A0/xx unknown
- 1992-10-28 EP EP92923060A patent/EP0610377B1/en not_active Expired - Lifetime
- 1992-10-28 AT AT92923060T patent/ATE198888T1/de active
- 1992-10-28 JP JP50846493A patent/JP3210017B2/ja not_active Expired - Fee Related
- 1992-10-28 CA CA002122270A patent/CA2122270C/en not_active Expired - Lifetime
- 1992-10-28 WO PCT/US1992/008981 patent/WO1993009114A1/en not_active Ceased
- 1992-10-28 AU AU29169/92A patent/AU665218B2/en not_active Ceased
- 1992-10-28 CZ CZ941027A patent/CZ102794A3/cs unknown
- 1992-10-28 HU HU9401256A patent/HUT70742A/hu unknown
- 1992-10-28 ES ES92923060T patent/ES2153364T3/es not_active Expired - Lifetime
- 1992-10-28 DE DE69231661T patent/DE69231661T2/de not_active Expired - Lifetime
- 1992-10-28 SG SG1996000735A patent/SG42920A1/en unknown
- 1992-10-28 NZ NZ244910A patent/NZ244910A/en unknown
- 1992-10-28 SK SK488-94A patent/SK48894A3/sk unknown
- 1992-10-28 MX MX9206222A patent/MX9206222A/es unknown
- 1992-10-28 MY MYPI92001943A patent/MY109529A/en unknown
- 1992-10-28 EP EP92118413A patent/EP0539938A1/en active Pending
- 1992-10-29 HR HR921145A patent/HRP921145A2/hr not_active Application Discontinuation
- 1992-10-29 YU YU94792A patent/YU94792A/sh unknown
- 1992-10-29 SI SI19929200285A patent/SI9200285A/sl unknown
- 1992-10-29 CN CN92113399A patent/CN1037267C/zh not_active Expired - Fee Related
-
1994
- 1994-04-29 NO NO941589A patent/NO941589L/no unknown
- 1994-04-29 FI FI941986A patent/FI941986A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993009114A1 (en) | 1993-05-13 |
| IL103558A0 (en) | 1993-03-15 |
| AU2916992A (en) | 1993-06-07 |
| NZ244910A (en) | 1996-01-26 |
| SG42920A1 (en) | 1997-10-17 |
| DE69231661D1 (de) | 2001-03-01 |
| CZ102794A3 (en) | 1995-03-15 |
| NO941589D0 (cg-RX-API-DMAC10.html) | 1994-04-29 |
| SI9200285A (en) | 1993-06-30 |
| MY109529A (en) | 1997-02-28 |
| DE69231661T2 (de) | 2001-08-02 |
| ATE198888T1 (de) | 2001-02-15 |
| YU94792A (sh) | 1995-12-04 |
| MX9206222A (es) | 1993-04-01 |
| JPH07500605A (ja) | 1995-01-19 |
| EP0610377A1 (en) | 1994-08-17 |
| CN1073944A (zh) | 1993-07-07 |
| NO941589L (cg-RX-API-DMAC10.html) | 1994-06-23 |
| AU665218B2 (en) | 1995-12-21 |
| CN1037267C (zh) | 1998-02-04 |
| HRP921145A2 (en) | 1994-08-31 |
| JP3210017B2 (ja) | 2001-09-17 |
| ES2153364T3 (es) | 2001-03-01 |
| CA2122270A1 (en) | 1993-05-13 |
| HU9401256D0 (en) | 1994-08-29 |
| EP0610377B1 (en) | 2001-01-24 |
| FI941986A7 (fi) | 1994-04-29 |
| SK48894A3 (en) | 1995-02-08 |
| CA2122270C (en) | 2006-05-23 |
| EP0539938A1 (en) | 1993-05-05 |
| FI941986A0 (fi) | 1994-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC4 | Cancellation of temporary protection due to refusal |