ATE198888T1 - Antifungizide trisubstituierte tetrahydrofurane - Google Patents

Antifungizide trisubstituierte tetrahydrofurane

Info

Publication number
ATE198888T1
ATE198888T1 AT92923060T AT92923060T ATE198888T1 AT E198888 T1 ATE198888 T1 AT E198888T1 AT 92923060 T AT92923060 T AT 92923060T AT 92923060 T AT92923060 T AT 92923060T AT E198888 T1 ATE198888 T1 AT E198888T1
Authority
AT
Austria
Prior art keywords
antifungicide
tetrahydrofuranes
trisubstituted
chem
lower alkyl
Prior art date
Application number
AT92923060T
Other languages
English (en)
Inventor
Anil K Saksena
Viyyoor M Girijavallabhan
Ashit K Ganguly
Raymond G Lovey
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE198888T1 publication Critical patent/ATE198888T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT92923060T 1991-10-30 1992-10-28 Antifungizide trisubstituierte tetrahydrofurane ATE198888T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78535791A 1991-10-30 1991-10-30
US90726292A 1992-07-01 1992-07-01
PCT/US1992/008981 WO1993009114A1 (en) 1991-10-30 1992-10-28 Tri-substituted tetrahydrofuran antifungals

Publications (1)

Publication Number Publication Date
ATE198888T1 true ATE198888T1 (de) 2001-02-15

Family

ID=27120397

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92923060T ATE198888T1 (de) 1991-10-30 1992-10-28 Antifungizide trisubstituierte tetrahydrofurane

Country Status (22)

Country Link
EP (2) EP0539938A1 (de)
JP (1) JP3210017B2 (de)
CN (1) CN1037267C (de)
AT (1) ATE198888T1 (de)
AU (1) AU665218B2 (de)
CA (1) CA2122270C (de)
CZ (1) CZ102794A3 (de)
DE (1) DE69231661T2 (de)
ES (1) ES2153364T3 (de)
FI (1) FI941986A (de)
HR (1) HRP921145A2 (de)
HU (1) HUT70742A (de)
IL (1) IL103558A0 (de)
MX (1) MX9206222A (de)
MY (1) MY109529A (de)
NO (1) NO941589L (de)
NZ (1) NZ244910A (de)
SG (1) SG42920A1 (de)
SI (1) SI9200285A (de)
SK (1) SK48894A3 (de)
WO (1) WO1993009114A1 (de)
YU (1) YU94792A (de)

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US5403937A (en) * 1993-04-30 1995-04-04 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
US5349099A (en) * 1993-12-13 1994-09-20 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
US5703079A (en) * 1993-12-21 1997-12-30 Schering Corporation Tetrahydrofuran antifungals
US5693626A (en) * 1993-12-21 1997-12-02 Schering Corporation Tetrahydrofuran antifungals
US5703236A (en) * 1993-12-21 1997-12-30 Schering Corporation Tetrahydrofuran antifungals
US5710154A (en) * 1993-12-21 1998-01-20 Schering Corporation Tetrahydrofuran antifungals
AU681753B2 (en) * 1993-12-21 1997-09-04 Merck Sharp & Dohme Corp. Tetrahydrofuran antifungals
US5714490A (en) * 1993-12-21 1998-02-03 Schering Corporation Tetrahydrofuran antifungals
US5661151A (en) * 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals
NZ278882A (en) * 1994-01-24 1997-06-24 Janssen Pharmaceutica Nv Piperazine-containing azole antifungal compounds
JP3828147B2 (ja) * 1994-04-19 2006-10-04 株式会社カネカ トリアゾール誘導体の製造法
US5442093A (en) * 1994-05-09 1995-08-15 Schering Corporation Process for preparing intermediates for the synthesis of antifungal agents
US5486625A (en) * 1994-07-08 1996-01-23 Schering Corporation Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents
EP0725146A4 (de) * 1994-07-18 1998-12-23 Daicel Chem Verfahren zur herstellung optischaktiver triazolverbindungen und methode zur razemisierung optischaktiver triazolverbindungen
US5616777A (en) * 1995-04-19 1997-04-01 Schering Corporation Chiral hydrazine derivatives
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
ATE240319T1 (de) * 1995-06-02 2003-05-15 Schering Corp Antifungale tetrahydrofurane
WO1997000255A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
TW593312B (en) * 1997-07-11 2004-06-21 Janssen Pharmaceutica Nv 2,4,4-trisubstituted-1,3-dioxolane antifungals
PL189317B1 (pl) * 1997-10-07 2005-07-29 Schering Corp Krystaliczny przeciwgrzybiczy polimorf (-)-4-[4-[4-[4-[(2R-cis)-5-(2,4-difluorofenylo)tetrahydro-5-(1H-1,2,4-triazol-1-ilo-metylo)furan-3-ilo]metoksy]fenylo]-1-piperazynylo]fenylo-2,4-dihydro-2-[(S)-1-etylo-2(S)-hydroksypropylo]-3H-1,2,4-triazol-3-onu
EA200401336A1 (ru) * 2002-04-12 2006-02-24 Ранбакси Лабораторис Лимитед Производные 2,2,4-тризамещенного тетрагидрофурана в качестве противогрибковых средств
AU2011254658B2 (en) 2010-05-19 2016-02-18 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
WO2011144653A1 (en) 2010-05-19 2011-11-24 Sandoz Ag Process for the preparation of chiral triazolones
WO2011144656A1 (en) 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
CN102892750B (zh) 2010-05-19 2016-03-02 桑多斯股份公司 制备手性酰肼的方法
CA2838051C (en) 2011-06-16 2019-09-24 Sandoz Ag Process for the preparation of a chiral compound
US9663499B2 (en) * 2013-06-07 2017-05-30 The California Institute For Biomedical Research Small molecule inhibitors of fibrosis
CN106397417A (zh) * 2016-08-30 2017-02-15 甘肃皓天化学科技有限公司 用于制备泊沙康唑的中间体的制备方法

Family Cites Families (13)

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US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
DE3346123A1 (de) 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
DK354185A (da) * 1984-08-31 1986-03-01 Hoffmann La Roche 1,3-dioxolanderivater
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US5006513A (en) 1987-11-09 1991-04-09 Miles Inc. Antimycotic compositions of nikkomycin compounds and azole antimycotica
EP0318214B1 (de) * 1987-11-20 1994-12-14 Schering Corporation Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte
US5002935A (en) 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
US5039676A (en) 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
US20040220100A1 (en) 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems

Also Published As

Publication number Publication date
SK48894A3 (en) 1995-02-08
NO941589D0 (de) 1994-04-29
DE69231661T2 (de) 2001-08-02
CN1037267C (zh) 1998-02-04
CZ102794A3 (en) 1995-03-15
WO1993009114A1 (en) 1993-05-13
FI941986A0 (fi) 1994-04-29
HU9401256D0 (en) 1994-08-29
DE69231661D1 (de) 2001-03-01
EP0539938A1 (de) 1993-05-05
CA2122270A1 (en) 1993-05-13
NZ244910A (en) 1996-01-26
SG42920A1 (en) 1997-10-17
HRP921145A2 (en) 1994-08-31
EP0610377A1 (de) 1994-08-17
YU94792A (sh) 1995-12-04
JPH07500605A (ja) 1995-01-19
HUT70742A (en) 1995-10-30
ES2153364T3 (es) 2001-03-01
JP3210017B2 (ja) 2001-09-17
AU665218B2 (en) 1995-12-21
EP0610377B1 (de) 2001-01-24
FI941986A (fi) 1994-04-29
SI9200285A (en) 1993-06-30
NO941589L (de) 1994-06-23
MY109529A (en) 1997-02-28
IL103558A0 (en) 1993-03-15
CN1073944A (zh) 1993-07-07
CA2122270C (en) 2006-05-23
AU2916992A (en) 1993-06-07
MX9206222A (es) 1993-04-01

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