HUT70485A - Substituted mono- and bipyridyl-methyl-pyridone derivatives and process for producing them - Google Patents

Substituted mono- and bipyridyl-methyl-pyridone derivatives and process for producing them Download PDF

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Publication number
HUT70485A
HUT70485A HU9401417A HU9401417A HUT70485A HU T70485 A HUT70485 A HU T70485A HU 9401417 A HU9401417 A HU 9401417A HU 9401417 A HU9401417 A HU 9401417A HU T70485 A HUT70485 A HU T70485A
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HU
Hungary
Prior art keywords
carbon atoms
group
straight
branched
hydrogen
Prior art date
Application number
HU9401417A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9401417D0 (en
Inventor
Peter Fey
Walter Huebsch
Hilmar Bischoff
Andreas Knorr
Siegfried Zaiss
Stanislav Kazda
Thomas Kraemer
Martin Beuck
Stefan Wohlfeil
Rudolf Hanko
Ulrich Mueller
Johannes-Peter Stasch
Juergen Dressel
Matthias Mueller-Gliemann
Dirk Denzer
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of HU9401417D0 publication Critical patent/HU9401417D0/hu
Publication of HUT70485A publication Critical patent/HUT70485A/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU9401417A 1993-05-13 1994-05-06 Substituted mono- and bipyridyl-methyl-pyridone derivatives and process for producing them HUT70485A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4316077A DE4316077A1 (de) 1993-05-13 1993-05-13 Substituierte Mono- und Bihydridylmethylpyridone

Publications (2)

Publication Number Publication Date
HU9401417D0 HU9401417D0 (en) 1994-08-29
HUT70485A true HUT70485A (en) 1995-10-30

Family

ID=6488035

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9401417A HUT70485A (en) 1993-05-13 1994-05-06 Substituted mono- and bipyridyl-methyl-pyridone derivatives and process for producing them

Country Status (21)

Country Link
US (1) US5407948A (cg-RX-API-DMAC10.html)
EP (1) EP0624583B1 (cg-RX-API-DMAC10.html)
JP (1) JPH06329669A (cg-RX-API-DMAC10.html)
CN (1) CN1102648A (cg-RX-API-DMAC10.html)
AT (1) ATE155782T1 (cg-RX-API-DMAC10.html)
AU (1) AU672679B2 (cg-RX-API-DMAC10.html)
CA (1) CA2123243A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ117294A3 (cg-RX-API-DMAC10.html)
DE (2) DE4316077A1 (cg-RX-API-DMAC10.html)
DK (1) DK0624583T3 (cg-RX-API-DMAC10.html)
ES (1) ES2105408T3 (cg-RX-API-DMAC10.html)
FI (1) FI942160L (cg-RX-API-DMAC10.html)
GR (1) GR3024465T3 (cg-RX-API-DMAC10.html)
HU (1) HUT70485A (cg-RX-API-DMAC10.html)
IL (1) IL109604A0 (cg-RX-API-DMAC10.html)
NO (1) NO941770L (cg-RX-API-DMAC10.html)
NZ (1) NZ260490A (cg-RX-API-DMAC10.html)
PH (1) PH30908A (cg-RX-API-DMAC10.html)
SK (1) SK55694A3 (cg-RX-API-DMAC10.html)
TW (1) TW245718B (cg-RX-API-DMAC10.html)
ZA (1) ZA943246B (cg-RX-API-DMAC10.html)

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DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
ATE274510T1 (de) 1998-06-19 2004-09-15 Chiron Corp Glycogen synthase kinase 3 inhibitoren
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
JP4164031B2 (ja) * 2002-02-14 2008-10-08 ファルマシア コーポレーション Ｐ３８ｍａｐキナーゼのモジュレータとしての置換されたピリジノン
US6946479B2 (en) * 2002-11-09 2005-09-20 The Procter & Gamble Company N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
US6930117B2 (en) * 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
US7786130B2 (en) 2005-08-29 2010-08-31 Vertex Pharmaceuticals Incorporated Pyridones useful as inhibitors of kinases
WO2007027528A2 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases
CA2620269A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AR059898A1 (es) * 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
EP2200985B1 (en) 2007-09-14 2011-07-13 Ortho-McNeil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
CA2696948C (en) * 2007-09-14 2013-04-30 Jose Maria Cid-Nunez 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
NZ584148A (en) * 2007-09-14 2011-05-27 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
CN101861316B (zh) * 2007-11-14 2013-08-21 奥梅-杨森制药有限公司 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
CN102143955B (zh) 2008-09-02 2013-08-14 Omj制药公司 作为代谢型谷氨酸受体调节剂的3-氮杂二环[3.1.0]己烷衍生物
WO2010043396A1 (en) 2008-10-16 2010-04-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
CN102439015B (zh) 2009-05-12 2015-05-13 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
ES2440001T3 (es) 2009-05-12 2014-01-27 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-A]piridina y su uso para el tratamiento o prevención de trastornos neurológicos y psiquiátricos
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
BR112012010766A2 (pt) * 2009-11-06 2015-10-06 Aerpio Therapeutics Inc composições e métodos de tratamento da colite e de outras doenças instestinais
CA2814998C (en) 2010-11-08 2019-10-29 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US9271967B2 (en) 2010-11-08 2016-03-01 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
ES2552879T3 (es) 2010-11-08 2015-12-02 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
LT3431106T (lt) 2014-01-21 2021-02-10 Janssen Pharmaceutica Nv Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas
EA033889B1 (ru) 2014-01-21 2019-12-05 Янссен Фармацевтика Нв Комбинация на основе лиганда sv2a и положительного аллостерического модулятора метаботропного глутаматергического рецептора 2 подтипа
AU2022215844A1 (en) 2021-02-02 2023-09-14 Liminal Biosciences Limited Gpr84 antagonists and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5196537A (en) * 1991-03-21 1993-03-23 G. D. Searle & Co. 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
US5128327A (en) * 1991-03-25 1992-07-07 Merck & Co., Inc. Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5332750A (en) * 1991-09-04 1994-07-26 Merck Patent Gesellschaft Mit Beschrankter Haftung 1,2-dihydro-2-oxopyridines
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
CN1102648A (zh) 1995-05-17
GR3024465T3 (en) 1997-11-28
ES2105408T3 (es) 1997-10-16
HU9401417D0 (en) 1994-08-29
JPH06329669A (ja) 1994-11-29
CZ117294A3 (en) 1994-11-16
AU672679B2 (en) 1996-10-10
ATE155782T1 (de) 1997-08-15
NO941770L (no) 1994-11-14
US5407948A (en) 1995-04-18
FI942160A0 (fi) 1994-05-10
DE59403427D1 (de) 1997-08-28
AU6056194A (en) 1994-11-17
IL109604A0 (en) 1994-08-26
CA2123243A1 (en) 1994-11-14
SK55694A3 (en) 1995-02-08
TW245718B (cg-RX-API-DMAC10.html) 1995-04-21
EP0624583A1 (de) 1994-11-17
PH30908A (en) 1997-12-23
FI942160A7 (fi) 1994-11-14
NO941770D0 (no) 1994-05-11
NZ260490A (en) 1995-12-21
DE4316077A1 (de) 1994-11-17
FI942160L (fi) 1994-11-14
ZA943246B (en) 1995-01-18
DK0624583T3 (da) 1998-03-02
EP0624583B1 (de) 1997-07-23

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Legal Events

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DFD9 Temporary protection cancelled due to non-payment of fee