HUT67667A - Pharmaceutical composition causes inhibition of phosphatidylinositol-3-kinase containing wortmannin and analogs thereof and process for its production - Google Patents
Pharmaceutical composition causes inhibition of phosphatidylinositol-3-kinase containing wortmannin and analogs thereof and process for its production Download PDFInfo
- Publication number
- HUT67667A HUT67667A HU9402128A HU9402128A HUT67667A HU T67667 A HUT67667 A HU T67667A HU 9402128 A HU9402128 A HU 9402128A HU 9402128 A HU9402128 A HU 9402128A HU T67667 A HUT67667 A HU T67667A
- Authority
- HU
- Hungary
- Prior art keywords
- kinase
- formula
- phosphatidylinositol
- compound
- pharmaceutical composition
- Prior art date
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- 239000012058 sterile packaged powder Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 108091005990 tyrosine-phosphorylated proteins Proteins 0.000 description 1
- 150000003668 tyrosines Chemical class 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/094,279 US5378725A (en) | 1993-07-19 | 1993-07-19 | Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9402128D0 HU9402128D0 (en) | 1994-09-28 |
| HUT67667A true HUT67667A (en) | 1995-04-28 |
Family
ID=22244209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9402128A HUT67667A (en) | 1993-07-19 | 1994-07-18 | Pharmaceutical composition causes inhibition of phosphatidylinositol-3-kinase containing wortmannin and analogs thereof and process for its production |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5378725A (2) |
| EP (1) | EP0635268A1 (2) |
| JP (1) | JPH0753370A (2) |
| KR (1) | KR950002755A (2) |
| CN (1) | CN1111127A (2) |
| AU (1) | AU678831B2 (2) |
| CA (1) | CA2128046A1 (2) |
| CZ (1) | CZ283806B6 (2) |
| HU (1) | HUT67667A (2) |
| IL (1) | IL110325A0 (2) |
| NO (1) | NO942641L (2) |
| PH (1) | PH30794A (2) |
| PL (1) | PL304317A1 (2) |
| RU (1) | RU94026082A (2) |
| TW (1) | TW287102B (2) |
| ZA (1) | ZA945103B (2) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5504103A (en) * | 1993-08-25 | 1996-04-02 | Eli Lilly And Company | Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof |
| US5468773A (en) * | 1993-08-25 | 1995-11-21 | Eli Lilly And Company | Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs |
| US7863429B2 (en) * | 1995-12-21 | 2011-01-04 | Qlt Inc. | Treatment of inflammatory diseases including psoriasis |
| US5910417A (en) * | 1996-05-31 | 1999-06-08 | National Jewish Center For Immunology And Respiratory Medicine | Regulation of cytokine production in a hematopoietic cell |
| US7670767B1 (en) | 1997-01-16 | 2010-03-02 | The Regents Of The University Of California | Genetic alterations associated with cancer |
| EP1072273B1 (en) * | 1998-03-24 | 2006-07-26 | Chugai Seiyaku Kabushiki Kaisha | Vascularization inhibitors |
| US6413773B1 (en) * | 1998-06-01 | 2002-07-02 | The Regents Of The University Of California | Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation |
| IL142094A0 (en) * | 1998-09-29 | 2002-03-10 | Gamida Cell Ltd | Methods of controlling proliferation and differentiation of stem and progenitor cells |
| WO2000041698A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
| US8124630B2 (en) * | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US6566081B1 (en) | 1999-10-06 | 2003-05-20 | The Brigham And Women's Hospital, Inc. | Methods of identifying a compound which modulates the non-transcriptional non-map-kinase induced effects of steroid hormones |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| CA2410514A1 (en) * | 2000-05-30 | 2001-12-06 | Advanced Research & Technology Institute | Compositions and methods for identifying agents which modulate pten function and pi-3 kinase pathways |
| AU2002258798A1 (en) * | 2001-04-13 | 2002-10-28 | Children's Hospital Medical Center | Methods for the treatment of hepatic disorders |
| US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
| GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| US6703414B2 (en) * | 2001-09-14 | 2004-03-09 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Device and method for treating restenosis |
| US20080108672A1 (en) * | 2002-01-11 | 2008-05-08 | Bernd Riedl | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors |
| IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
| EP1465982A4 (en) * | 2002-01-25 | 2006-06-07 | Gamida Cell Ltd | PROCESS FOR EXPANSION OF STEM AND PRESERVATIVE CELLS AND EXPANDED CELL POPULATIONS THEREWITH OBTAINED |
| EP2324825A1 (en) * | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Aryl ureas with angiogenesis inhibiting activity |
| US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
| WO2004005532A2 (en) * | 2002-07-10 | 2004-01-15 | Massachusetts Institute Of Technology | Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans |
| US20050054097A1 (en) * | 2002-11-17 | 2005-03-10 | Tony Peled | EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| GB0304632D0 (en) * | 2003-02-28 | 2003-04-02 | Proxara Biotechnology Ltd | Method |
| EP1601759A4 (en) * | 2003-03-07 | 2007-02-14 | Gamida Cell Ltd | EXPANSION OF RENEWABLE STEM CELL POPULATIONS USING PI-3 KINASE MODULATORS |
| EP1615669A2 (en) * | 2003-04-23 | 2006-01-18 | Wyeth Holdings Corporation | Peg-wortmannin conjugates |
| DK1626714T3 (da) * | 2003-05-20 | 2007-10-15 | Bayer Pharmaceuticals Corp | Dirarylurinstoffer mod sygdomme medieret af PDGFR |
| IL161903A0 (en) * | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
| CN1856469B (zh) * | 2003-07-23 | 2013-03-06 | 拜耳医药保健有限责任公司 | 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 |
| JP2007501836A (ja) | 2003-08-13 | 2007-02-01 | クドス ファーマシューティカルズ リミテッド | アミノピロン類及びａｔｍ阻害剤としてのその使用 |
| WO2005016349A1 (en) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Methods of inhibiting leukocyte accumulation |
| US20050043239A1 (en) * | 2003-08-14 | 2005-02-24 | Jason Douangpanya | Methods of inhibiting immune responses stimulated by an endogenous factor |
| ES2605792T3 (es) | 2004-05-13 | 2017-03-16 | Icos Corporation | Quinazolinona usada como inhibidor de la fosfatidilinositol 3-quinasa delta humana |
| CA2567883A1 (en) * | 2004-05-25 | 2005-12-15 | Icos Corporation | Methods for treating and/or preventing aberrant proliferation of hematopoietic cells |
| EP1799812A4 (en) * | 2004-09-16 | 2009-09-09 | Gamida Cell Ltd | EX VIVO CULTIVATION METHODS OF STEM CELLS AND PRECURSOR BY CO-CULTURE WITH MESENCHYMAL CELLS |
| WO2006032869A1 (en) | 2004-09-20 | 2006-03-30 | Kudos Pharmaceuticals Limited | Dna-pk inhibitors |
| CN101039952A (zh) * | 2004-10-13 | 2007-09-19 | 惠氏公司 | 作为pi3k抑制剂的17－羟基渥曼青霉素类似物 |
| CN1875959B (zh) * | 2004-10-14 | 2010-05-12 | 孔庆忠 | 一种抗癌药物组合物 |
| CN100369632C (zh) * | 2004-10-14 | 2008-02-20 | 孔庆忠 | 抗癌药物组合物 |
| WO2006085067A1 (en) | 2005-02-09 | 2006-08-17 | Kudos Pharmaceuticals Limited | Atm inhibitors |
| WO2006089106A2 (en) * | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
| AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| US20090305236A1 (en) * | 2005-05-11 | 2009-12-10 | Genetic Technologies Limited | Methods of enriching fetal cells |
| EP1888065A2 (en) * | 2005-05-27 | 2008-02-20 | Bayer HealthCare AG | Combination therapy comprising diaryl ureas for treating diseases |
| JP2007063205A (ja) * | 2005-08-31 | 2007-03-15 | Japan Science & Technology Agency | 神経因性疼痛治療剤 |
| US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
| WO2008056368A2 (en) * | 2006-11-09 | 2008-05-15 | Gamida-Cell Ltd. | Use of ex-vivo cultured hematopoietic cells for treatment of peripheral vascular diseases |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| US20100109416A1 (en) * | 2008-11-03 | 2010-05-06 | Jones Margaret L | Adjustable safety harness |
| CN102271683B (zh) | 2008-11-13 | 2014-07-09 | 吉里德卡利斯托加公司 | 恶性血液病的治疗 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| US20100233733A1 (en) * | 2009-02-10 | 2010-09-16 | Nodality, Inc., A Delaware Corporation | Multiple mechanisms for modulation of the pi3 kinase pathway |
| SG174529A1 (en) | 2009-03-24 | 2011-10-28 | Gilead Calistoga Llc | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| KR20120005523A (ko) * | 2009-04-20 | 2012-01-16 | 길리아드 칼리스토가 엘엘씨 | 고형 종양의 치료 방법 |
| MX2012000817A (es) | 2009-07-21 | 2012-05-08 | Gilead Calistoga Llc | Tratamiento para desordenes del higado con inhibidores pi3k. |
| BRPI1107182B1 (pt) * | 2011-12-29 | 2022-03-08 | Fundação De Amparo À Pesquisa Do Estado De Minas Gerais - Fapemig | Composições farmacêuticas contendo ang-(1-7) ou outro agonista do receptor mas em combinação com inibidores de pi3k/akt para tratamento terapêutico anticâncer |
| EP2814950A1 (en) | 2012-02-13 | 2014-12-24 | Gamida-Cell Ltd. | Mesenchymal stem cells conditioned medium and methods of generating and using the same |
| CA2864305C (en) | 2012-03-05 | 2021-02-16 | Gilead Calistoga Llc | Polymorphic forms of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one |
| US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
| US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
| WO2014203129A1 (en) | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Combinations of benzopyran compounds, compositions and uses thereof |
| ES2752552T3 (es) | 2013-12-20 | 2020-04-06 | Gilead Calistoga Llc | Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa |
| JP2017500319A (ja) | 2013-12-20 | 2017-01-05 | ギリアード カリストガ エルエルシー | （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態 |
| NZ726360A (en) | 2014-06-13 | 2018-04-27 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
| CN104774239B (zh) * | 2015-03-13 | 2017-01-04 | 暨南大学 | 多节孢绿胶霉素类化合物及其用途 |
| CN107058137B (zh) * | 2017-06-14 | 2020-02-07 | 海正药业(杭州)有限公司 | 一种渥曼青霉及其生产渥曼青霉素的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3668222A (en) * | 1969-05-14 | 1972-06-06 | Sandoz Ltd | 11-desacetoxy-wortmannin |
| US4988682A (en) * | 1989-02-03 | 1991-01-29 | University Of Pittsburgh | Myo-inositol analogs and method for their use |
| JPH0328948A (ja) * | 1989-06-27 | 1991-02-07 | Nec Corp | 入出力制御装置の動作状態情報収集方式 |
-
1993
- 1993-07-19 US US08/094,279 patent/US5378725A/en not_active Expired - Fee Related
- 1993-11-23 TW TW082109883A patent/TW287102B/zh active
-
1994
- 1994-07-13 ZA ZA945103A patent/ZA945103B/xx unknown
- 1994-07-13 CZ CZ941692A patent/CZ283806B6/cs unknown
- 1994-07-14 IL IL11032594A patent/IL110325A0/xx unknown
- 1994-07-14 CA CA002128046A patent/CA2128046A1/en not_active Abandoned
- 1994-07-14 NO NO942641A patent/NO942641L/no unknown
- 1994-07-15 EP EP94305192A patent/EP0635268A1/en not_active Withdrawn
- 1994-07-15 PL PL94304317A patent/PL304317A1/xx unknown
- 1994-07-15 PH PH48651A patent/PH30794A/en unknown
- 1994-07-18 KR KR1019940017228A patent/KR950002755A/ko not_active Withdrawn
- 1994-07-18 JP JP6165068A patent/JPH0753370A/ja active Pending
- 1994-07-18 HU HU9402128A patent/HUT67667A/hu unknown
- 1994-07-18 AU AU67540/94A patent/AU678831B2/en not_active Ceased
- 1994-07-18 RU RU94026082/14A patent/RU94026082A/ru unknown
- 1994-07-18 CN CN94108398A patent/CN1111127A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NO942641D0 (no) | 1994-07-14 |
| JPH0753370A (ja) | 1995-02-28 |
| HU9402128D0 (en) | 1994-09-28 |
| NO942641L (no) | 1995-01-20 |
| US5378725A (en) | 1995-01-03 |
| AU6754094A (en) | 1995-01-27 |
| EP0635268A1 (en) | 1995-01-25 |
| AU678831B2 (en) | 1997-06-12 |
| PH30794A (en) | 1997-10-17 |
| RU94026082A (ru) | 1996-05-20 |
| TW287102B (2) | 1996-10-01 |
| ZA945103B (en) | 1996-03-27 |
| KR950002755A (ko) | 1995-02-16 |
| CA2128046A1 (en) | 1995-01-20 |
| CZ169294A3 (en) | 1995-02-15 |
| CZ283806B6 (cs) | 1998-06-17 |
| PL304317A1 (en) | 1995-01-23 |
| IL110325A0 (en) | 1994-10-21 |
| CN1111127A (zh) | 1995-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFD9 | Temporary protection cancelled due to non-payment of fee |