HUT67048A - Method for production of conjugates - Google Patents

Method for production of conjugates

Info

Publication number
HUT67048A
HUT67048A HU9202219A HU9202219A HUT67048A HU T67048 A HUT67048 A HU T67048A HU 9202219 A HU9202219 A HU 9202219A HU 9202219 A HU9202219 A HU 9202219A HU T67048 A HUT67048 A HU T67048A
Authority
HU
Hungary
Prior art keywords
conjugates
antibody
production
toxin
tumours
Prior art date
Application number
HU9202219A
Other languages
English (en)
Other versions
HU9202219D0 (en
HU215243B (hu
Inventor
Leif Lindholm
Peter Lind
Andrew Firman Wright
John Edward Fitton
David Charles Blakey
Jan Holmgren
Original Assignee
Kabi Pharmacia Ab
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia Ab, Zeneca Ltd filed Critical Kabi Pharmacia Ab
Publication of HU9202219D0 publication Critical patent/HU9202219D0/hu
Publication of HUT67048A publication Critical patent/HUT67048A/hu
Publication of HU215243B publication Critical patent/HU215243B/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44Antibodies bound to carriers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046Stomach, Intestines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6863Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Bipolar Transistors (AREA)
  • Semiconductor Lasers (AREA)
  • Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU9202219A 1991-07-03 1992-07-03 Eljárás konjugátumok előállítására HU215243B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919114399A GB9114399D0 (en) 1991-07-03 1991-07-03 Conjugates

Publications (3)

Publication Number Publication Date
HU9202219D0 HU9202219D0 (en) 1992-10-28
HUT67048A true HUT67048A (en) 1995-01-30
HU215243B HU215243B (hu) 1998-11-30

Family

ID=10697775

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9202219A HU215243B (hu) 1991-07-03 1992-07-03 Eljárás konjugátumok előállítására

Country Status (24)

Country Link
EP (1) EP0528527B1 (hu)
JP (1) JP3735379B2 (hu)
KR (1) KR100252147B1 (hu)
AT (1) ATE164768T1 (hu)
AU (1) AU665546B2 (hu)
CA (1) CA2073113C (hu)
CZ (1) CZ209792A3 (hu)
DE (1) DE69225035T2 (hu)
DK (1) DK0528527T3 (hu)
ES (1) ES2113923T3 (hu)
FI (1) FI106928B (hu)
GB (2) GB9114399D0 (hu)
GR (1) GR3026575T3 (hu)
HU (1) HU215243B (hu)
IE (1) IE922190A1 (hu)
IL (1) IL102399A (hu)
MY (1) MY110513A (hu)
NO (1) NO308539B1 (hu)
NZ (1) NZ243437A (hu)
PT (1) PT100660B (hu)
SK (1) SK209792A3 (hu)
TW (1) TW329425B (hu)
ZA (1) ZA924973B (hu)
ZW (1) ZW10192A1 (hu)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5686121A (en) * 1979-12-14 1981-07-13 Teijin Ltd Antitumor proten complex and its preparation
ATE68703T1 (de) 1984-02-08 1991-11-15 Cetus Corp Toxinkonjugate.
US5165923A (en) * 1989-11-20 1992-11-24 Imperial Cancer Research Technology Methods and compositions for the treatment of hodgkin's disease
ES2094231T3 (es) * 1990-07-20 1997-01-16 Pharmacia & Upjohn Ab Conjugados de anticuerpos superantigenos especificos de una diana y su preparacion.

Also Published As

Publication number Publication date
ZA924973B (en) 1993-04-28
GR3026575T3 (en) 1998-07-31
TW329425B (en) 1998-04-11
AU1943092A (en) 1993-01-07
SK209792A3 (en) 1994-06-08
GB9212880D0 (en) 1992-07-29
CZ209792A3 (en) 1993-01-13
FI106928B (fi) 2001-05-15
KR930001928A (ko) 1993-02-22
EP0528527A2 (en) 1993-02-24
NO922383L (no) 1993-01-04
FI923085A (fi) 1993-01-04
PT100660B (pt) 1999-06-30
MY110513A (en) 1998-07-31
GB9114399D0 (en) 1991-08-21
DE69225035T2 (de) 1998-08-13
ZW10192A1 (en) 1993-03-31
DK0528527T3 (da) 1999-01-18
JPH05320065A (ja) 1993-12-03
ES2113923T3 (es) 1998-05-16
IL102399A (en) 2003-05-29
PT100660A (pt) 1993-10-29
CA2073113A1 (en) 1993-01-04
IL102399A0 (en) 1993-01-14
NO922383D0 (no) 1992-06-17
JP3735379B2 (ja) 2006-01-18
HU9202219D0 (en) 1992-10-28
AU665546B2 (en) 1996-01-11
IE922190A1 (en) 1993-01-13
NO308539B1 (no) 2000-09-25
DE69225035D1 (de) 1998-05-14
CA2073113C (en) 2004-09-14
HU215243B (hu) 1998-11-30
NZ243437A (en) 1994-10-26
ATE164768T1 (de) 1998-04-15
FI923085A0 (fi) 1992-07-03
EP0528527A3 (en) 1993-03-17
KR100252147B1 (ko) 2000-09-01
EP0528527B1 (en) 1998-04-08

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