HUT64843A - Method for producing substituted cyclohexane derivatives - Google Patents
Method for producing substituted cyclohexane derivatives Download PDFInfo
- Publication number
- HUT64843A HUT64843A HU9302527A HU9302527A HUT64843A HU T64843 A HUT64843 A HU T64843A HU 9302527 A HU9302527 A HU 9302527A HU 9302527 A HU9302527 A HU 9302527A HU T64843 A HUT64843 A HU T64843A
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- compound
- hydroxy
- group
- hydrogen
- Prior art date
Links
- 0 O[C@](C[C@](C[C@]1OC(c2ccc(*Cc3ccccc3)cc2)=O)(C(O)=O)O)[C@]1O Chemical compound O[C@](C[C@](C[C@]1OC(c2ccc(*Cc3ccccc3)cc2)=O)(C(O)=O)O)[C@]1O 0.000 description 2
- HMFCRSKLXUFEPP-UHFFFAOYSA-N C=[O]C1C(C[O]#C)CCCC1 Chemical compound C=[O]C1C(C[O]#C)CCCC1 HMFCRSKLXUFEPP-UHFFFAOYSA-N 0.000 description 1
- QFJBZZPMSSVQFI-RMKNXTFCSA-N CC(C(CC(C1=C)OC(/C=C/c(cc2)ccc2O)=O)C(O)=O)C1=C Chemical compound CC(C(CC(C1=C)OC(/C=C/c(cc2)ccc2O)=O)C(O)=O)C1=C QFJBZZPMSSVQFI-RMKNXTFCSA-N 0.000 description 1
- OETSFOXBSYSUAB-UHFFFAOYSA-N CC1C=C(C)C=CC1O Chemical compound CC1C=C(C)C=CC1O OETSFOXBSYSUAB-UHFFFAOYSA-N 0.000 description 1
- LGAQBYWKWZHOKB-BIAAXOCRSA-N O[C@H](C[C@](C[C@H]1OC(c(cc2)ccc2O)=O)(C(O)=O)O)[C@H]1O Chemical compound O[C@H](C[C@](C[C@H]1OC(c(cc2)ccc2O)=O)(C(O)=O)O)[C@H]1O LGAQBYWKWZHOKB-BIAAXOCRSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/383—Cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4230156 | 1992-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HU9302527D0 HU9302527D0 (en) | 1993-11-29 |
| HUT64843A true HUT64843A (en) | 1994-03-28 |
Family
ID=6467599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9302527A HUT64843A (en) | 1992-09-09 | 1993-09-07 | Method for producing substituted cyclohexane derivatives |
Country Status (22)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4404848A1 (de) * | 1994-02-16 | 1995-08-17 | Hoechst Ag | Substituierte Cyclohexanolester, ihre Verwendung zur Behandlung von Krankheiten und pharmazeutische Präparate |
| DE4408082A1 (de) * | 1994-03-10 | 1995-09-14 | Hoechst Ag | Substituierte Propan-Derivate, Verfahren zu ihrer Herstellung und die Anwendung der Verbindungen zur Behandlung von Krankheiten |
| DE4416433A1 (de) * | 1994-05-10 | 1995-11-16 | Hoechst Ag | Cyclohexan-Derivate, Verfahren zu ihrer Herstellung und die Verwendung der Verbindungen zur Behandlung von Krankheiten |
| AR012449A1 (es) * | 1997-04-18 | 2000-10-18 | Hoechst Marion Roussell Deutschland Gmbh | Kodaistatinas a, b, c y d, proceso para su produccion, y su uso. |
| JP4810558B2 (ja) * | 1997-08-08 | 2011-11-09 | 江崎グリコ株式会社 | リン酸化糖およびその製造方法 |
| DE19740080A1 (de) * | 1997-09-12 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Neue Phthalaldehyd-Derivate, Verfahren zu deren Herstellung und deren Verwendung |
| EP1090136B1 (en) * | 1998-06-24 | 2006-05-31 | Sanofi-Aventis Deutschland GmbH | Mumbaistatin, a process for its production and its use as a pharmaceutical |
| AU779352B2 (en) * | 1999-10-25 | 2005-01-20 | Sanofi-Aventis Deutschland Gmbh | Aromatic di-keto derivatives, processes for their production and their use as a pharmaceutical |
| PE20021091A1 (es) * | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
| JP5226304B2 (ja) * | 2004-06-03 | 2013-07-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体の調製用中間体 |
| ZA200700755B (en) * | 2004-07-26 | 2009-05-27 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes |
| WO2009046308A1 (en) | 2007-10-03 | 2009-04-09 | Eisai R & D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin b analogs |
| MX2010010902A (es) | 2008-04-04 | 2010-12-21 | Eisai R&D Man Co Ltd | Analogos de halicondrina b. |
| US20100112098A1 (en) * | 2008-10-31 | 2010-05-06 | Naturex, S.A. | Effects of a decaffeinated green coffee extract on body weight control by regulation of glucose metabolism |
| MX2012008510A (es) | 2010-01-26 | 2012-11-21 | Eisai R&D Man Co Ltd | Derivados de furo [3, 2-b] pirano utiles en la sintesis de analogos de halicondrina b. |
| WO2015066729A1 (en) | 2013-11-04 | 2015-05-07 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| EP3505520A1 (en) | 2013-12-06 | 2019-07-03 | Eisai R&D Management Co., Ltd. | Methods useful in the synthesis of halichondrin b analogs |
| MX392296B (es) | 2015-05-07 | 2025-03-24 | Eisai R&D Man Co Ltd | Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina. |
| MX377663B (es) | 2016-02-12 | 2025-03-11 | Eisai R&D Man Co Ltd | Intermediarios en la sintesis de eribulina y metodos de sintesis relacionados. |
| JP7068204B2 (ja) | 2016-06-30 | 2022-05-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンマクロライドおよびその類縁体の合成に有用なプリンス反応および中間体 |
| US11542269B2 (en) | 2018-01-03 | 2023-01-03 | Eisai R&D Management Co., Ltd. | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60192555A (ja) * | 1984-03-13 | 1985-10-01 | Osaka Chem Lab | 抗アレルギ−食品 |
| JPS60243016A (ja) * | 1984-05-17 | 1985-12-03 | Tsumura Juntendo Inc | 抗インフルエンザウイルス剤 |
| EP0464858A1 (en) * | 1984-05-23 | 1992-01-08 | Green Cross Corporation | A lipoxygenase inhibitor |
| DE3603576A1 (de) * | 1986-02-06 | 1987-08-13 | Code Kaffee Handel | Verwendung von gerbstoffen und/oder chlorogensaeure sowie nahrungs-, genuss- und/oder arzneimittel mit gerbstoff- und/oder chlorogensaeurezusatz |
-
1993
- 1993-09-03 TW TW082107191A patent/TW255880B/zh active
- 1993-09-06 DE DE59309649T patent/DE59309649D1/de not_active Expired - Fee Related
- 1993-09-06 AT AT93114260T patent/ATE181237T1/de not_active IP Right Cessation
- 1993-09-06 DK DK93114260T patent/DK0587087T3/da active
- 1993-09-06 EP EP93114260A patent/EP0587087B1/de not_active Expired - Lifetime
- 1993-09-06 ES ES93114260T patent/ES2135429T3/es not_active Expired - Lifetime
- 1993-09-07 PH PH46828A patent/PH30278A/en unknown
- 1993-09-07 IL IL10693593A patent/IL106935A/xx not_active IP Right Cessation
- 1993-09-07 US US08/116,564 patent/US5451573A/en not_active Expired - Fee Related
- 1993-09-07 HU HU9302527A patent/HUT64843A/hu unknown
- 1993-09-07 FI FI933902A patent/FI933902A7/fi unknown
- 1993-09-08 NO NO933201A patent/NO179671C/no not_active IP Right Cessation
- 1993-09-08 CZ CZ931867A patent/CZ284995B6/cs not_active IP Right Cessation
- 1993-09-08 AU AU46170/93A patent/AU662836B2/en not_active Ceased
- 1993-09-08 ZA ZA936610A patent/ZA936610B/xx unknown
- 1993-09-08 CA CA002105707A patent/CA2105707A1/en not_active Abandoned
- 1993-09-08 RU RU93045145A patent/RU2131248C1/ru active
- 1993-09-08 PL PL93300328A patent/PL300328A1/xx unknown
- 1993-09-08 CN CN93116663A patent/CN1042329C/zh not_active Expired - Fee Related
- 1993-09-08 JP JP5223056A patent/JPH06211737A/ja not_active Abandoned
- 1993-09-09 KR KR1019930018066A patent/KR100299205B1/ko not_active Expired - Fee Related
-
1999
- 1999-08-11 GR GR990402034T patent/GR3030953T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFA9 | Temporary protection cancelled due to abandonment |