HUT64568A - Method for producing antibody-antagonists of human interleukin-4 - Google Patents

Method for producing antibody-antagonists of human interleukin-4

Info

Publication number
HUT64568A
HUT64568A HU9202073A HU207392A HUT64568A HU T64568 A HUT64568 A HU T64568A HU 9202073 A HU9202073 A HU 9202073A HU 207392 A HU207392 A HU 207392A HU T64568 A HUT64568 A HU T64568A
Authority
HU
Hungary
Prior art keywords
antagonists
binding
receptors
human interleukin
producing antibody
Prior art date
Application number
HU9202073A
Other languages
English (en)
Other versions
HU215245B (hu
HU9202073D0 (en
Inventor
Lata Ramanathan
Gail Foure Seelig
Paul P Trotta
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HU9202073D0 publication Critical patent/HU9202073D0/hu
Publication of HUT64568A publication Critical patent/HUT64568A/hu
Publication of HU215245B publication Critical patent/HU215245B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HU9202073A 1989-12-20 1990-12-18 Eljárás a humán interleukin-4 (IL-4) polipeptidek, ezekkel termelt antitestek és az antitesteket tartalmazó gyógyszerkészítmények előállítására HU215245B (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45357089A 1989-12-20 1989-12-20

Publications (3)

Publication Number Publication Date
HU9202073D0 HU9202073D0 (en) 1992-09-28
HUT64568A true HUT64568A (en) 1994-01-28
HU215245B HU215245B (hu) 1998-11-30

Family

ID=23801108

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9202073A HU215245B (hu) 1989-12-20 1990-12-18 Eljárás a humán interleukin-4 (IL-4) polipeptidek, ezekkel termelt antitestek és az antitesteket tartalmazó gyógyszerkészítmények előállítására

Country Status (26)

Country Link
US (1) US6358509B1 (hu)
EP (1) EP0506826B1 (hu)
JP (1) JPH0730116B2 (hu)
KR (1) KR960016862B1 (hu)
AT (1) ATE136906T1 (hu)
AU (1) AU639754B2 (hu)
CA (1) CA2071908C (hu)
CZ (1) CZ283050B6 (hu)
DE (1) DE69026627T2 (hu)
DK (1) DK0506826T3 (hu)
ES (1) ES2085983T3 (hu)
FI (1) FI104180B1 (hu)
GR (1) GR3020325T3 (hu)
HU (1) HU215245B (hu)
IE (1) IE74708B1 (hu)
IL (1) IL96714A0 (hu)
MX (1) MX9203401A (hu)
MY (1) MY106507A (hu)
NO (1) NO922457D0 (hu)
NZ (1) NZ236511A (hu)
OA (1) OA09704A (hu)
PT (1) PT96230B (hu)
SK (1) SK635290A3 (hu)
TW (1) TW221675B (hu)
WO (1) WO1991009059A1 (hu)
ZA (1) ZA9010190B (hu)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714146A (en) * 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
ZA946765B (en) 1993-09-02 1996-02-15 Dartmouth College Methods of prolonged suppression of humoral immunity
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
BR9407575A (pt) * 1993-09-07 1996-07-16 Smithkline Beecham Corp Recombinaçao il4 de anticorpos uteis no tratamento de desordens do il4
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5597710A (en) * 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5705154A (en) * 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
JP2001511187A (ja) * 1997-02-28 2001-08-07 エンゾー セラピュウティクス， インコーポレイテッド 選択的免疫ダウンレギュレーション（ｓｉｄｒ）を行う新規プロセス
US7553487B2 (en) 1998-12-14 2009-06-30 Genetics Institute, Llc Method and compositions for treating asthma
CN104611339A (zh) 1998-12-14 2015-05-13 遗传研究所有限责任公司 细胞因子受体链
DE60135170D1 (de) * 2000-04-06 2008-09-18 Fujifilm Corp Farbstoffkomplex und optisches Informationsaufzeichnungsmedium
EP2292665B1 (en) 2000-05-26 2015-07-08 Immunex Corporation Use of interleukin-4 antibodies and compositions thereof
US20020076409A1 (en) * 2000-07-12 2002-06-20 March Carl J. Method for treating cancer
US20030170258A1 (en) * 2001-05-09 2003-09-11 Enzo Therapeutics, Inc. Novel processes implementing selective immune down regulation (SIDR)
FR2838444B1 (fr) * 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
AU2003251633A1 (en) * 2002-07-01 2004-01-19 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Il-21 as a regulator of immunoglobin production
US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
WO2004096849A2 (en) * 2003-04-25 2004-11-11 University Of Manitoba Peptide-based cytokine/chemokine vaccines against allergy
ATE548388T1 (de) 2003-11-07 2012-03-15 Immunex Corp An den interleukin-4-rezeptor bindende antikörper
HUE049161T2 (hu) 2003-12-23 2020-09-28 Genentech Inc Új anti-IL13 antitestek és alkalmazásaik
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
AR049390A1 (es) 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
AR050044A1 (es) * 2004-08-03 2006-09-20 Novartis Ag Anticuerpo especifico de il-4
CN102216323B (zh) * 2008-11-17 2016-08-03 哥本哈根大学 用于调节慢性炎症反应和治疗自身免疫性疾病的源自il-4的肽
EP2560683B2 (en) 2010-04-23 2022-07-20 F. Hoffmann-La Roche AG Production of heteromultimeric proteins
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
MX355255B (es) 2011-02-04 2018-04-11 Genentech Inc Variantes de fc y métodos para su producción.
MX2015013901A (es) * 2013-04-05 2015-12-11 Genentech Inc Anticuerpos anti-il-4 y anticuerpos biespecificos y sus usos.
SG10201802525QA (en) 2013-09-13 2018-04-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
BR112016004437A2 (pt) 2013-09-13 2017-10-17 Genentech Inc métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit
CN106471117A (zh) 2014-05-06 2017-03-01 豪夫迈·罗氏有限公司 使用哺乳动物细胞产生异多聚体蛋白
RU2758092C1 (ru) * 2018-02-01 2021-10-26 Бэйцзин Кавин Текнолоджи Шеа-Холдинг Ко., Лтд. АНТИТЕЛО К IL-4Rα И ЕГО ПРИМЕНЕНИЕ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
US5013824A (en) * 1985-11-19 1991-05-07 Schering Corporation Human interleukin-4 peptides and conjugates thereof
IL80678A (en) * 1985-11-19 1999-05-09 Schering Biotech Corp Human interleukin-4
ZA872781B (en) 1986-05-19 1987-10-05 Immunology Ventures B-cell stimulating factor
EP0397764A1 (en) * 1988-02-02 1990-11-22 Schering Biotech Corporation Method of reducing immunoglobulin e responses

Also Published As

Publication number Publication date
CA2071908A1 (en) 1991-06-21
FI104180B (fi) 1999-11-30
WO1991009059A1 (en) 1991-06-27
US6358509B1 (en) 2002-03-19
DE69026627D1 (de) 1996-05-23
NO922457L (no) 1992-06-19
MX9203401A (es) 1992-07-01
CZ283050B6 (cs) 1997-12-17
CA2071908C (en) 2002-04-30
MY106507A (en) 1995-06-30
IE904589A1 (en) 1991-07-03
IE74708B1 (en) 1997-07-30
GR3020325T3 (en) 1996-09-30
DE69026627T2 (de) 1996-08-22
DK0506826T3 (da) 1996-05-13
FI104180B1 (fi) 1999-11-30
FI922847A0 (fi) 1992-06-18
EP0506826A1 (en) 1992-10-07
ZA9010190B (en) 1991-08-28
SK279933B6 (sk) 1999-06-11
ATE136906T1 (de) 1996-05-15
SK635290A3 (en) 1999-06-11
AU639754B2 (en) 1993-08-05
NO922457D0 (no) 1992-06-19
AU7176291A (en) 1991-07-18
PT96230A (pt) 1991-10-15
KR960016862B1 (ko) 1996-12-23
HU215245B (hu) 1998-11-30
PT96230B (pt) 1998-06-30
CZ635290A3 (en) 1997-08-13
JPH04506359A (ja) 1992-11-05
JPH0730116B2 (ja) 1995-04-05
EP0506826B1 (en) 1996-04-17
IL96714A0 (en) 1991-09-16
HU9202073D0 (en) 1992-09-28
OA09704A (en) 1993-08-30
NZ236511A (en) 1993-02-25
TW221675B (hu) 1994-03-11
KR920703642A (ko) 1992-12-18
FI922847A (fi) 1992-06-18
ES2085983T3 (es) 1996-06-16

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee