HUT64051A - Process for producing aryl group- or aromatic heterocyclic group-substituted cyclic aminoquinolone and naphthyridone derivatives and pharmaceutical compositions comprising same - Google Patents

Process for producing aryl group- or aromatic heterocyclic group-substituted cyclic aminoquinolone and naphthyridone derivatives and pharmaceutical compositions comprising same

Info

Publication number
HUT64051A
HUT64051A HU9301536A HU9301536A HUT64051A HU T64051 A HUT64051 A HU T64051A HU 9301536 A HU9301536 A HU 9301536A HU 9301536 A HU9301536 A HU 9301536A HU T64051 A HUT64051 A HU T64051A
Authority
HU
Hungary
Prior art keywords
aminoquinolone
pharmaceutical compositions
aromatic heterocyclic
same
substituted cyclic
Prior art date
Application number
HU9301536A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9301536D0 (en
Inventor
Tomio Kimura
Tetsushi Katsube
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of HU9301536D0 publication Critical patent/HU9301536D0/hu
Publication of HUT64051A publication Critical patent/HUT64051A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9301536A 1992-05-27 1993-05-26 Process for producing aryl group- or aromatic heterocyclic group-substituted cyclic aminoquinolone and naphthyridone derivatives and pharmaceutical compositions comprising same HUT64051A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15891292 1992-05-27

Publications (2)

Publication Number Publication Date
HU9301536D0 HU9301536D0 (en) 1993-09-28
HUT64051A true HUT64051A (en) 1993-11-29

Family

ID=15682065

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9301536A HUT64051A (en) 1992-05-27 1993-05-26 Process for producing aryl group- or aromatic heterocyclic group-substituted cyclic aminoquinolone and naphthyridone derivatives and pharmaceutical compositions comprising same

Country Status (18)

Country Link
US (2) US5519016A (zh)
EP (1) EP0572259A1 (zh)
KR (1) KR100266305B1 (zh)
CN (1) CN1042936C (zh)
AU (1) AU656859B2 (zh)
CA (1) CA2096998A1 (zh)
CZ (1) CZ99693A3 (zh)
FI (1) FI932412A (zh)
HU (1) HUT64051A (zh)
ID (1) ID20476A (zh)
IL (1) IL105806A (zh)
MX (1) MX9303158A (zh)
NO (1) NO304832B1 (zh)
NZ (1) NZ247720A (zh)
PH (1) PH31078A (zh)
RU (1) RU2124510C1 (zh)
TW (1) TW234121B (zh)
ZA (1) ZA933732B (zh)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
EP0773214A4 (en) * 1994-07-18 1998-04-15 Ube Industries TRIFLUORMETHYLQUINOLINE CARBONIC ACID DERIVATIVES
DE4425649A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue 1-[4-(Aminomethyl)phenyl] substituierte Chinoloncarbonsäuren
DE4425647A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren
DE4425660A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 7-substituierte 1-[4-(1H-1,2,4-triazol-1-yl-methyl)phenyl] substituierte Chinoloncarbonsäuren
US5763450A (en) * 1994-11-24 1998-06-09 Hoffmann-La Roche Inc. Substituted benzyl pyrimidines
US5620997A (en) * 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
CA2232728C (en) * 1995-09-22 2003-11-04 Wakunaga Pharmaceutical Co., Ltd. Novel pyridonecarboxylic acid derivatives or their salts, and antibacterial agents containing the same as their effective components
US6001863A (en) * 1996-11-26 1999-12-14 Warner-Lambert Company Isothiazolones
US6387928B1 (en) * 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
EP1015445B1 (en) 1997-09-15 2009-02-25 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
DE19751948A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
DE69931974D1 (de) * 1998-08-12 2006-07-27 Ihara Chemical Ind Co N-Cyclopropyl-2-difluormethoxy-3-bromanilin und ein Zwischenprodukt zu seiner Herstellung
PT1140932E (pt) * 1998-12-21 2004-08-31 Aventis Pharma Sa Derivados de 1,8-benzonaftiridina
EP1262477B1 (en) * 2000-02-09 2008-09-03 Daiichi Sankyo Company, Limited Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
US6514529B2 (en) 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
MY127336A (en) * 2000-03-22 2006-11-30 Upjohn Co Container for linezolid iv solution
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
PE20020578A1 (es) 2000-10-10 2002-08-14 Upjohn Co Una composicion de antibiotico topico para el tratamiento de infecciones oculares
IL155678A0 (en) 2000-12-14 2003-11-23 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
AU3089102A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial quinolones
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
CA2477044A1 (en) * 2002-02-22 2003-09-04 Pharmacia Corporation Ophthalmic formulation with gum system
BR0307898A (pt) * 2002-02-22 2004-12-07 Pharmacia Corp Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio
WO2003099815A1 (en) 2002-05-28 2003-12-04 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
CZ2004764A3 (cs) * 2002-11-20 2005-02-16 Japan Tobacco Inc 4-Oxochinolinová sloučenina a její použití jako inhibitoru HIV-integrázy
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
DE60314920T2 (de) 2003-09-04 2008-03-13 Wockhardt Ltd. Benzochinolizin-2-carbonsäureargininsalz- tetrahydrat
ES2232309B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Procedimiento simplificado para la obtencion de gatifloxacino.
DE602005023717D1 (de) * 2004-03-10 2010-11-04 Usa Chinolin-4-one als inhibitoren der retroviralen integrase zur behandlung von hiv, aids und aids-related complex (arc)
US7531554B2 (en) * 2004-05-20 2009-05-12 Japan Tobacco Inc. 4-oxoquinoline compound and use thereof as HIV integrase inhibitor
MY134672A (en) * 2004-05-20 2007-12-31 Japan Tobacco Inc Stable crystal of 4-oxoquinoline compound
KR100589429B1 (ko) 2004-08-31 2006-06-14 한국화학연구원 Ｎ-1 위치에 아미노피리딜기가 치환된 퀴놀론 유도체의 제조방법
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7732612B2 (en) * 2004-09-09 2010-06-08 Janssen Pharmaceutica, N.V. 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
JP2008519842A (ja) * 2004-11-11 2008-06-12 アキリオン ファーマシューティカルズ，インコーポレーテッド 抗感染剤としての８ａ，９−ジヒドロ−４ａ−ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物
WO2006074317A1 (en) * 2005-01-05 2006-07-13 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]naphthalene-3,4-diones and related compounds as anti-infective agents
WO2006084053A1 (en) * 2005-02-02 2006-08-10 Achillion Pharmaceuticals, Inc. 8-n-substituted-2h-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
KR20070107123A (ko) * 2005-02-16 2007-11-06 아칠리온 파르마세우티칼스 인코포레이티드 항-감염제들로서의 새로운 이소티아졸로퀴놀론들 및 관련화합물들
DE602006017082D1 (de) 2005-07-27 2010-11-04 Achillion Pharmaceuticals Inc 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dione und verwandte verbindungen als antiinfektive mittel
US8383819B2 (en) * 2006-03-06 2013-02-26 Japan Tobacco Inc. Method for producing 4-oxoquinoline compound
SMP200800058B (it) 2006-03-28 2009-09-07 Procter & Gamble Sali e polimorfi malati di un acido (3s, 5s) -7- [3-ammino-5-metilpiperidinil]-1-ciclopropil-1,4-diidro-8-metossi-4-osso-3-chinolincarbossilico
CN101045724B (zh) * 2006-03-28 2011-08-17 宝洁公司 用于制备喹诺酮中间体的偶联方法
KR101030202B1 (ko) * 2006-03-28 2011-04-22 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체의 제조를 위한 수소화물 환원 방법
US7456279B2 (en) 2006-03-28 2008-11-25 The Procter & Gamble Company Coupling process for preparing quinolone intermediates
WO2009002870A1 (en) * 2007-06-22 2008-12-31 Cylene Pharmaceuticals, Inc. Methods for treating aberrant cell proliferation disorders
US20080318939A1 (en) * 2007-06-22 2008-12-25 Whitten Jeffrey P Methods for treating ophthalmic disorders
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
MX2010002667A (es) * 2007-09-11 2010-04-01 Activx Biosciences Inc Cianoaminoquinolonas y tetrazoloaminoquinolonas como inhibidores de gsk-3.
BRPI0816814B1 (pt) * 2007-09-12 2021-08-31 Kyorin Pharmaceutical Co. Ltd Composto, composição farmacêutica e uso de um composto
WO2009049030A1 (en) * 2007-10-09 2009-04-16 Triton Biopharma, Llc Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter
WO2009064836A2 (en) * 2007-11-15 2009-05-22 University Of Maryland, Baltimore Kynurenine-aminotransferase inhibitors
CA2711500A1 (en) * 2008-01-07 2009-07-16 Huanming Chen Novel hiv integrase inhibitors and methods of use
NZ595448A (en) * 2009-04-03 2013-01-25 Achillion Pharmaceuticals Inc Hydroxythienoquinolones and related compounds as anti-infective agents
WO2010131054A1 (en) 2009-05-15 2010-11-18 Bradford Pharma Limited Redox drug derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5097032A (en) * 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
US5210193A (en) * 1986-01-17 1993-05-11 American Cyanamid Company Piperazine derivatives
US4840956A (en) * 1986-02-18 1989-06-20 Warner-Lambert Company Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
IT1197841B (it) * 1986-10-14 1988-12-06 Mediolanum Farmaceutici Srl Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione
JPH0751579B2 (ja) * 1987-11-07 1995-06-05 日本新薬株式会社 キノリンカルボン酸誘導体
WO1990013542A1 (fr) * 1989-04-28 1990-11-15 Daiichi Pharmaceutical Co., Ltd. Medicament anti-hiv
DE3934082A1 (de) * 1989-10-12 1991-04-18 Bayer Ag Chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel
JPH0754830Y2 (ja) * 1990-01-24 1995-12-18 株式会社ユニシアジェックス 荷重センサ取付構造
KR920004385A (ko) * 1990-08-09 1992-03-27 와꾸나가 기스께 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제
WO1992021659A1 (en) * 1991-05-28 1992-12-10 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative

Also Published As

Publication number Publication date
FI932412A0 (fi) 1993-05-26
CA2096998A1 (en) 1993-11-28
NO304832B1 (no) 1999-02-22
IL105806A0 (en) 1993-09-22
ID20476A (id) 1998-12-24
NO931867D0 (no) 1993-05-24
NZ247720A (en) 1994-09-27
TW234121B (zh) 1994-11-11
FI932412A (fi) 1993-11-28
CZ99693A3 (en) 1993-12-15
KR100266305B1 (ko) 2000-09-15
IL105806A (en) 1998-02-22
US5519016A (en) 1996-05-21
ZA933732B (en) 1993-12-15
AU3981593A (en) 1993-12-02
KR930023360A (ko) 1993-12-18
HU9301536D0 (en) 1993-09-28
US5688791A (en) 1997-11-18
EP0572259A1 (en) 1993-12-01
RU2124510C1 (ru) 1999-01-10
NO931867L (no) 1993-11-29
MX9303158A (es) 1994-04-29
PH31078A (en) 1998-02-05
CN1086515A (zh) 1994-05-11
CN1042936C (zh) 1999-04-14
AU656859B2 (en) 1995-02-16

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