HUT44259A - Process for preparing cefem carboxylic acid - Google Patents

Process for preparing cefem carboxylic acid

Info

Publication number
HUT44259A
HUT44259A HU872882A HU288287A HUT44259A HU T44259 A HUT44259 A HU T44259A HU 872882 A HU872882 A HU 872882A HU 288287 A HU288287 A HU 288287A HU T44259 A HUT44259 A HU T44259A
Authority
HU
Hungary
Prior art keywords
group
substituted
carboxylic acid
heterocyclic ring
unsubstituted
Prior art date
Application number
HU872882A
Other languages
English (en)
Other versions
HU198500B (en
Inventor
Yoshiyuki Zama
Nobuo Ishiyama
Tsuneo Saita
Masao Hirose
Masaaki Yokoyama
Taiji Asano
Hisato Senda
Keiji Sekine
Shigeru Sanai
Takanobu Naito
Original Assignee
Kaken Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharma Co Ltd filed Critical Kaken Pharma Co Ltd
Priority to HU892782A priority Critical patent/HU209126B/hu
Priority to HU825790A priority patent/HU207296B/hu
Publication of HUT44259A publication Critical patent/HUT44259A/hu
Publication of HU198500B publication Critical patent/HU198500B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU872882A 1986-07-01 1987-06-25 Process for producing cefemcarboxylic acid derivatives and pharmaceutical composition comprising same HU198500B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HU892782A HU209126B (en) 1986-07-01 1987-06-25 Process for producing 2-(2-amino-thiazol-4-yl)-2-(4-pyridon-2-yl-methoxy-imino)-acetic acid derivatives
HU825790A HU207296B (en) 1986-07-01 1987-06-25 Process for producing substituted 2-hydroxy-methyl-4-pyridone derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15270686 1986-07-01
JP19159086 1986-08-18

Publications (2)

Publication Number Publication Date
HUT44259A true HUT44259A (en) 1988-02-29
HU198500B HU198500B (en) 1989-10-30

Family

ID=26481559

Family Applications (3)

Application Number Title Priority Date Filing Date
HU892782A HUT56099A (en) 1986-07-01 1987-06-25 Process for producing 2-(2-amino-thiazol-4-yl)-2-(4-pyridon-2-yl-methoxy-imino)-acetic acid derivatives
HU908257A HUT56071A (en) 1986-07-01 1987-06-25 Process for producing substituted 2-hydroxymethyl-4-pyridone derivatives
HU872882A HU198500B (en) 1986-07-01 1987-06-25 Process for producing cefemcarboxylic acid derivatives and pharmaceutical composition comprising same

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HU892782A HUT56099A (en) 1986-07-01 1987-06-25 Process for producing 2-(2-amino-thiazol-4-yl)-2-(4-pyridon-2-yl-methoxy-imino)-acetic acid derivatives
HU908257A HUT56071A (en) 1986-07-01 1987-06-25 Process for producing substituted 2-hydroxymethyl-4-pyridone derivatives

Country Status (10)

Country Link
US (2) US4822786A (hu)
EP (1) EP0251299B1 (hu)
KR (1) KR930007418B1 (hu)
CN (1) CN1022036C (hu)
AT (1) ATE110729T1 (hu)
AU (3) AU597676B2 (hu)
CA (1) CA1283404C (hu)
DE (1) DE3750443T2 (hu)
ES (1) ES2062974T3 (hu)
HU (3) HUT56099A (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028601A (en) * 1987-04-30 1991-07-02 Meiji Saika Kaisha, Ltd. Cephalosporin compounds and antibacterial agents
JPH0633281B2 (ja) * 1987-11-11 1994-05-02 明治製菓株式会社 新規セファロスポリン化合物及び抗菌剤
JPH0686463B2 (ja) * 1988-07-01 1994-11-02 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JPH0248580A (ja) * 1988-08-10 1990-02-19 Meiji Seika Kaisha Ltd 新規セファロスポリン系化合物及び抗菌剤
EP0400805A1 (en) * 1989-04-25 1990-12-05 Toshiyasu Ishimaru Cephalosporin compounds and their use
JPH03176473A (ja) * 1989-12-01 1991-07-31 Kaken Pharmaceut Co Ltd ピリジン―ｎ―オキシド誘導体及びその製法
EP0579221A1 (en) * 1992-07-17 1994-01-19 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
JPH11124384A (ja) * 1997-10-17 1999-05-11 Otsuka Chem Co Ltd ３−セフェム化合物の製造法
US6352770B1 (en) 1999-01-15 2002-03-05 Bic Corporation Correction tape having dye migration blocking properties
ES2373461T3 (es) 2005-12-07 2012-02-03 Basilea Pharmaceutica Ag Antibióticos útiles de monobactama.
NZ579375A (en) 2007-03-23 2012-02-24 Basilea Pharmaceutica Ag Combination medicaments for treating bacterial infections
US8680136B2 (en) 2010-08-10 2014-03-25 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US9012491B2 (en) 2011-08-31 2015-04-21 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN104981239B (zh) 2013-01-04 2019-01-04 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EA201591003A1 (ru) 2013-01-04 2015-12-30 Ремпекс Фармасьютикалз, Инк. Производные бороновой кислоты и их терапевтическое применение
PT3140310T (pt) 2014-05-05 2019-11-18 Rempex Pharmaceuticals Inc Síntese de sais de boronato e utilizações dos mesmos
US9687497B1 (en) 2014-05-05 2017-06-27 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
KR20170007448A (ko) 2014-05-19 2017-01-18 렘펙스 파머수티클스 인코퍼레이티드 보론산 유도체 및 그의 치료적 용도
MX2016016666A (es) 2014-07-01 2017-08-08 Rempex Pharmaceuticals Inc Derivados de acido boronico y usos terapeuticos de los mismos.
US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
CN107207537B (zh) 2014-12-19 2019-05-31 莱姆派克斯制药公司 用于生产硼酸衍生物的设备和连续流方法
WO2016149393A1 (en) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
WO2019075084A1 (en) 2017-10-11 2019-04-18 Qpex Biopharma, Inc. BORONIC ACID DERIVATIVES AND SYNTHESIS THEREOF
CN112409383A (zh) * 2020-11-30 2021-02-26 上海交通大学医学院 一种氨噻肟哌啶酮头孢菌素的制备及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
JPS59167576A (ja) * 1983-03-15 1984-09-21 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS59219282A (ja) * 1983-05-28 1984-12-10 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物およびその中間体
GB8329043D0 (en) * 1983-10-31 1983-11-30 Hider R C Pharmaceutical compositions
GB8410289D0 (en) * 1984-04-19 1984-05-31 Callingham B A Pharmaceutical compositions
NZ215527A (en) * 1985-04-01 1989-06-28 Mochida Pharm Co Ltd Cephalosporin derivatives and pharmaceutical compositions
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
ES2062974T3 (es) 1995-01-01
AU597676B2 (en) 1990-06-07
DE3750443D1 (de) 1994-10-06
US4883879A (en) 1989-11-28
KR930007418B1 (ko) 1993-08-10
CN87104590A (zh) 1988-01-13
AU7493187A (en) 1988-01-07
CN1022036C (zh) 1993-09-08
AU1962892A (en) 1992-09-10
AU6214390A (en) 1990-12-20
AU627067B2 (en) 1992-08-13
AU635174B2 (en) 1993-03-11
EP0251299B1 (en) 1994-08-31
EP0251299A2 (en) 1988-01-07
KR880001674A (ko) 1988-04-26
HUT56099A (en) 1991-07-29
HU198500B (en) 1989-10-30
DE3750443T2 (de) 1995-04-20
HUT56071A (en) 1991-07-29
CA1283404C (en) 1991-04-23
US4822786A (en) 1989-04-18
ATE110729T1 (de) 1994-09-15
EP0251299A3 (en) 1989-10-11
HU908257D0 (en) 1991-06-28

Similar Documents

Publication Publication Date Title
HUT44259A (en) Process for preparing cefem carboxylic acid
HUT45984A (en) Process for production of quinoline-derivatives and of their medically acceptable acid-additioned salts
AU1811988A (en) A process for the preparation of substituted indolin-2-one derivatives
AU1198988A (en) 7-Aminocephalosporanic acid derivatives
EP0214600A3 (en) Cephalosporin derivatives
EP0317484A3 (en) N,n'-carboxyl-bis-(4-ethyl-2,3-dioxo)-piperazine, process for the preparation thereof and use thereof
NO875002D0 (no) Imidazolderivater, samt fremgangsmaate for fremstilling av slike.
YU40388A (en) Process for making imidazole derivatives
AU576887B2 (en) 1,6-naphthyridine derivatives
ES8801639A1 (es) Procedimiento para la obtencion de derivados del acido barbiturico
GR3015314T3 (en) Penem derivatives, production and use thereof.
ES8304971A1 (es) Un procedimiento para la preparacion de derivados de tiocarbapenem 3-sustituidos.
HU913293D0 (en) Process for the production of pierazine derivatives and medical preparations containing them
YU44630B (en) Process for preparing 6-/d(-)-alpha(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-phenylacetamido/phenicilanic acid
IE893533L (en) Substituted 3-aminosydnonimines, processes for their¹preparation and their use
EP0169995A3 (en) A high yield process for preparing beta-lactam antibiotics having a high purity degree
NZ215439A (en) Benzo(c) 1,5 naphthyridines and pharmaceutical compositions
ES8506725A1 (es) Procedimiento para la preparacion de un derivado de cefalosporina

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee