HUP9904454A2 - Többlépéses eljárás nagytisztaságú deferoxamin-mezilát só előállítására - Google Patents

Többlépéses eljárás nagytisztaságú deferoxamin-mezilát só előállítására

Info

Publication number
HUP9904454A2
HUP9904454A2 HU9904454A HUP9904454A HUP9904454A2 HU P9904454 A2 HUP9904454 A2 HU P9904454A2 HU 9904454 A HU9904454 A HU 9904454A HU P9904454 A HUP9904454 A HU P9904454A HU P9904454 A2 HUP9904454 A2 HU P9904454A2
Authority
HU
Hungary
Prior art keywords
deferoxamine
producing
high purity
several steps
base
Prior art date
Application number
HU9904454A
Other languages
English (en)
Inventor
Vilmos Kéri
Zoltán Czövek
Attila Mező
Original Assignee
BIOGAL Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOGAL Gyógyszergyár Rt. filed Critical BIOGAL Gyógyszergyár Rt.
Priority to HU9904454A priority Critical patent/HU227315B1/hu
Publication of HU9904454D0 publication Critical patent/HU9904454D0/hu
Priority to CZ20021823A priority patent/CZ20021823A3/cs
Priority to PL00355328A priority patent/PL355328A1/xx
Priority to AU19351/01A priority patent/AU1935101A/en
Priority to RU2002114073/04A priority patent/RU2002114073A/ru
Priority to JP2001541852A priority patent/JP2003515579A/ja
Priority to MXPA02005377A priority patent/MXPA02005377A/es
Priority to CN00818750A priority patent/CN1433399A/zh
Priority to EP00982299A priority patent/EP1235791A4/en
Priority to SK747-2002A priority patent/SK7472002A3/sk
Priority to KR1020027007014A priority patent/KR20020067044A/ko
Priority to CA002392925A priority patent/CA2392925A1/en
Priority to US10/168,042 priority patent/US6858414B2/en
Priority to PCT/US2000/032574 priority patent/WO2001040164A1/en
Priority to YU39602A priority patent/YU39602A/sh
Publication of HUP9904454A2 publication Critical patent/HUP9904454A2/hu
Priority to ZA200204030A priority patent/ZA200204030B/en
Publication of HU227315B1 publication Critical patent/HU227315B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgya többlépéses tisztítási eljárás nagytisztaságúdeferoxamin-mezilát előállítására deferoxamin-sóból deferoxaminbázison keresztül. Az eljárás szerint először a deferoxamin-só vizesoldatát adszorpciós gyantán kromatografálják, majd víz-oldószerelegyből lúgos pH-n leválasztják a deferoxamin bázist, végül adeferoxamin bázisból víz-oldószer vagy metanol-oldószer elegybenmezilát sót képeznek. Ó
HU9904454A 1999-12-01 1999-12-01 Process having several steps for producing deferoxamine mesilate of high purity HU227315B1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
HU9904454A HU227315B1 (en) 1999-12-01 1999-12-01 Process having several steps for producing deferoxamine mesilate of high purity
YU39602A YU39602A (sh) 1999-12-01 2000-11-30 Višestepeni postupak za dobijanje deferoksamin metilsulfonil soli visoke čistoće
EP00982299A EP1235791A4 (en) 1999-12-01 2000-11-30 MULTI-STAGE PROCESS FOR THE PRODUCTION OF HIGH-PURITY DEFEROXAMINE MESYLATE SALT
KR1020027007014A KR20020067044A (ko) 1999-12-01 2000-11-30 고순도의 데페록사민 메실레이트 염의 다단 제조 방법
AU19351/01A AU1935101A (en) 1999-12-01 2000-11-30 A multistage process for the preparation of highly pure deferoxamine mesylate salt
RU2002114073/04A RU2002114073A (ru) 1999-12-01 2000-11-30 Многостадийный способ получения высокоочищенной соли мезилата дефероксамина
JP2001541852A JP2003515579A (ja) 1999-12-01 2000-11-30 高純度デフェロキサミン・メシレート塩の製造のための多段階プロセス
MXPA02005377A MXPA02005377A (es) 1999-12-01 2000-11-30 Proceso de multiples etapas para la preparacion de una sal de mesilato de deferoxamina altamente puro.
CN00818750A CN1433399A (zh) 1999-12-01 2000-11-30 制备高纯去铁胺甲磺酸盐的多步法
CZ20021823A CZ20021823A3 (cs) 1999-12-01 2000-11-30 Vícestupňový způsob přípravy vysoce přečištěných solí deferoxamin-mesylátu
SK747-2002A SK7472002A3 (en) 1999-12-01 2000-11-30 A multistage process for the preparation of highly pure deferoxamine mesylate salt
PL00355328A PL355328A1 (en) 1999-12-01 2000-11-30 A multistage process for the preparation of highly pure deferoxamine mesylate salt
CA002392925A CA2392925A1 (en) 1999-12-01 2000-11-30 A multistage process for the preparation of highly pure deferoxamine mesylate salt
US10/168,042 US6858414B2 (en) 1999-12-01 2000-11-30 Multistage process for the preparation of highly pure deferoxamine mesylate salt
PCT/US2000/032574 WO2001040164A1 (en) 1999-12-01 2000-11-30 A multistage process for the preparation of highly pure deferoxamine mesylate salt
ZA200204030A ZA200204030B (en) 1999-12-01 2002-05-21 A multistage process for the preparation of highly pure deferoxamine mesylate salt.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9904454A HU227315B1 (en) 1999-12-01 1999-12-01 Process having several steps for producing deferoxamine mesilate of high purity

Publications (3)

Publication Number Publication Date
HU9904454D0 HU9904454D0 (en) 2000-02-28
HUP9904454A2 true HUP9904454A2 (hu) 2001-08-28
HU227315B1 HU227315B1 (en) 2011-03-28

Family

ID=90000087

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904454A HU227315B1 (en) 1999-12-01 1999-12-01 Process having several steps for producing deferoxamine mesilate of high purity

Country Status (15)

Country Link
EP (1) EP1235791A4 (hu)
JP (1) JP2003515579A (hu)
KR (1) KR20020067044A (hu)
CN (1) CN1433399A (hu)
AU (1) AU1935101A (hu)
CA (1) CA2392925A1 (hu)
CZ (1) CZ20021823A3 (hu)
HU (1) HU227315B1 (hu)
MX (1) MXPA02005377A (hu)
PL (1) PL355328A1 (hu)
RU (1) RU2002114073A (hu)
SK (1) SK7472002A3 (hu)
WO (1) WO2001040164A1 (hu)
YU (1) YU39602A (hu)
ZA (1) ZA200204030B (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111544374A (zh) * 2020-05-13 2020-08-18 中国人民解放军总医院第四医学中心 注射用甲磺酸去铁胺在治疗增龄性骨丢失及骨髓干细胞衰老中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH438351A (de) * 1959-09-25 1967-06-30 Ciba Geigy Verfahren zur Herstellung neuer Wuchsstoffe
FR1898M (fr) * 1961-04-07 1963-07-08 Ciba Geigy Nouvelle substance utilisable en thérapeutique.
WO1993003045A1 (en) * 1991-08-09 1993-02-18 The Regents Of The University Of California Process for purer organic metal ion chelate complexes
US5254724A (en) * 1991-10-30 1993-10-19 University Of Florida Research Foundation, Inc. Method for synthesis of desferrioxamine B, analogs and homologs thereof
HU214452B (hu) * 1992-06-01 1998-03-30 BIOGAL Gyógyszergyár Rt. Eljárás nagytisztaságú deferoxamin-B-sók előállítására

Also Published As

Publication number Publication date
HU227315B1 (en) 2011-03-28
EP1235791A4 (en) 2006-03-08
CA2392925A1 (en) 2001-06-07
CN1433399A (zh) 2003-07-30
MXPA02005377A (es) 2002-12-05
ZA200204030B (en) 2003-05-21
CZ20021823A3 (cs) 2003-02-12
YU39602A (sh) 2005-07-19
SK7472002A3 (en) 2003-03-04
PL355328A1 (en) 2004-04-19
EP1235791A1 (en) 2002-09-04
JP2003515579A (ja) 2003-05-07
HU9904454D0 (en) 2000-02-28
RU2002114073A (ru) 2004-01-20
WO2001040164A1 (en) 2001-06-07
AU1935101A (en) 2001-06-12
KR20020067044A (ko) 2002-08-21

Similar Documents

Publication Publication Date Title
IL131755A0 (en) Crystalline amine salt of cefdinir
HUP0300299A2 (hu) Szabad aminosavakat tartalmazó kompozíció
AU2003222816A1 (en) Sterilisation system, especially for sterilising drinking water and industrial water and the production and use of said sterilisation system
HUP0402485A2 (hu) A clopidogrel hidrogénszulfát polimorf módosulatai
HUP0402112A2 (hu) Eljárás kristályos imipenem előállítására
MY128168A (en) Method for producing high-purity hydrochloric acid.
SE9903291D0 (sv) New process
HUP0201152A2 (hu) Eljárás nem proteinogén L-aminosavak előállítására
MXPA04001035A (es) Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso.
SG86468A1 (en) Production process of high-purity gypsum
WO2004089826A3 (en) Sodium cyanide process
PT1283281E (pt) Processo de produção eletroquímica de cloro a partir de soluções aquosas de cloreto de hidrogénio
BRPI0408417A (pt) métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição
CA2380495A1 (en) Method for the production of a solvent-free .alpha.-lipoic acid
HUP9904454A2 (hu) Többlépéses eljárás nagytisztaságú deferoxamin-mezilát só előállítására
HUP0102104A2 (hu) Nem-hidratált gabapentin polimorf, előállítására alkalmas eljárás és gyógyszer minőségű gabapentin előállítására való alkalmazása
FR2793701B1 (fr) Procede de production d'oxygene gazeux
HUP0300708A2 (hu) Kettős fémcianidok egylépéses szintézise
HUP0104345A2 (hu) Eljárás ammónium-szulfát tisztítására
HUP0102562A2 (hu) Expressziós vektor egyetlen lépésből álló tisztítási eljárásban történő alkalmazásra
TW200517368A (en) Process
HUP0401234A2 (hu) Pravastatin stabil gyógyászati kompozíciója és eljárás az előállítására
HRP20050415B1 (en) A process for the purification of 1,4-butanediol mononitrate
WO2001066467A8 (en) Precipitated aragonite and a process for producing it
DE50105715D1 (de) Verfahren zur herstellung von dnda

Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: TEVA GYOGYSZERGYAR ZRT., HU

Free format text: FORMER OWNER(S): BIOGAL GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees