MXPA04001035A - Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso. - Google Patents
Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso.Info
- Publication number
- MXPA04001035A MXPA04001035A MXPA04001035A MXPA04001035A MXPA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A MX PA04001035 A MXPA04001035 A MX PA04001035A
- Authority
- MX
- Mexico
- Prior art keywords
- zaleplon
- purification
- crystalline forms
- regioisomer
- byproduct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
Se revela un proceso de purificacion que es capaz de separar zaleplon y un regioisomero de zaleplon que tiende a formarse como un subproducto en la sintesis quimica de zaleplon, que deriva en zaleplon esencialmente puro. Ademas, formas cristalinas novedosas de zaleplon son accesibles con el proceso.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30939101P | 2001-08-01 | 2001-08-01 | |
US31790701P | 2001-09-06 | 2001-09-06 | |
US38819902P | 2002-06-12 | 2002-06-12 | |
US10/170,673 US6884888B2 (en) | 2001-06-12 | 2002-06-12 | Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon) |
PCT/US2002/024553 WO2003011228A2 (en) | 2001-08-01 | 2002-08-01 | Purification and crystalline forms of zaleplon |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04001035A true MXPA04001035A (es) | 2004-06-22 |
Family
ID=27496922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04001035A MXPA04001035A (es) | 2001-08-01 | 2002-08-01 | Proceso para purificar n-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)fenil]-n-etilacetamida (zaleplon) y formas cristalinas de zaleplon accesibles con este proceso. |
Country Status (14)
Country | Link |
---|---|
US (2) | US6852858B2 (es) |
EP (1) | EP1430054A4 (es) |
JP (1) | JP2005523874A (es) |
CA (1) | CA2453751A1 (es) |
CZ (1) | CZ200471A3 (es) |
HR (1) | HRP20040180A2 (es) |
HU (1) | HUP0402253A3 (es) |
IL (1) | IL160076A0 (es) |
IS (1) | IS7128A (es) |
MX (1) | MXPA04001035A (es) |
NO (1) | NO20040887L (es) |
PL (1) | PL374176A1 (es) |
SK (1) | SK472004A3 (es) |
WO (1) | WO2003011228A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1305315A2 (en) * | 2000-08-03 | 2003-05-02 | Wyeth | Polymorphs of zaleplon and methods for the preparation thereof |
TR200402588T3 (tr) * | 2001-06-12 | 2004-11-22 | Biogal Gyogyszergyar Rt | N-[3-(3-siyanopirazolo[1,5-A]pirimidin-7-il)fenil]-N- etilasetamidin(zaleplon) üretim işlemi |
US20050032818A1 (en) * | 2001-06-12 | 2005-02-10 | Entire Interest | N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon |
JP2005523874A (ja) * | 2001-08-01 | 2005-08-11 | テバ ジョジセルジャール レースベニュタールシャシャーグ | N−〔3−(3−シアノピラゾロ〔1,5−a〕ピリミジン−7−イル)フェニル〕−N−エチルアセタミド(ザレプロン)の精製方法、及び当該方法により得られうるザレプロンの結晶型 |
ZA200406577B (en) * | 2002-02-15 | 2006-06-28 | Teva Gyogyzeryan Reszvenytarsa | Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom |
CZ20023575A3 (cs) * | 2002-10-25 | 2004-01-14 | Léčiva, A.S. | Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu) |
DE112004001615T5 (de) | 2003-09-04 | 2006-06-14 | Cipla Ltd. | Zaleplon-Synthese |
JP2007517876A (ja) * | 2004-01-14 | 2007-07-05 | マリンクロッド・インコーポレイテッド | 選択的ピラゾロピリミジン類の合成のための2相法 |
HUP0400325A3 (en) * | 2004-02-02 | 2005-11-28 | Richter Gedeon Vegyeszet | Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates |
JPWO2006062129A1 (ja) * | 2004-12-08 | 2008-06-12 | 株式会社クラレ | (5α,7α)−3−スピロ−2’−(1’,3’−ジオキソラン)−24−オキソコレスト−22−エン−7−イルベンゾアートの製造方法 |
WO2007043939A1 (en) * | 2005-10-07 | 2007-04-19 | Astrazeneca Ab | Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a |
US7761955B1 (en) * | 2007-08-30 | 2010-07-27 | Hiltz Erik D | Dual port cleaning and extraction apparatus |
US8171598B1 (en) | 2010-07-26 | 2012-05-08 | Erik Daniel Hiltz | Dual port cleaning and extraction apparatus |
TW201946625A (zh) | 2013-11-15 | 2019-12-16 | 美商阿克比治療有限公司 | {[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基}乙酸之固體型式,其組合物及用途 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626538A (en) | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
US5714607A (en) | 1995-12-01 | 1998-02-03 | American Cyanamid Company | Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide |
US6485746B1 (en) | 2000-08-25 | 2002-11-26 | Neurocrine Biosciences, Inc. | Controlled-release sedative-hypnotic compositions and methods related thereto |
DE10004790B4 (de) | 2000-02-01 | 2004-09-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung von Zaleplon, Verfahren zu seiner Herstellung und seine Verwendung |
WO2001078725A2 (en) | 2000-04-13 | 2001-10-25 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
EP1305315A2 (en) | 2000-08-03 | 2003-05-02 | Wyeth | Polymorphs of zaleplon and methods for the preparation thereof |
AR029780A1 (es) | 2000-12-13 | 2003-07-16 | Gador Sa | Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida |
TR200402588T3 (tr) | 2001-06-12 | 2004-11-22 | Biogal Gyogyszergyar Rt | N-[3-(3-siyanopirazolo[1,5-A]pirimidin-7-il)fenil]-N- etilasetamidin(zaleplon) üretim işlemi |
JP2005523874A (ja) | 2001-08-01 | 2005-08-11 | テバ ジョジセルジャール レースベニュタールシャシャーグ | N−〔3−(3−シアノピラゾロ〔1,5−a〕ピリミジン−7−イル)フェニル〕−N−エチルアセタミド(ザレプロン)の精製方法、及び当該方法により得られうるザレプロンの結晶型 |
EP1476446B1 (de) * | 2002-02-14 | 2007-08-01 | Cilag AG | Verfahren zur herstellung von n-ethyl-n-(3-(3-cyanopyrazolo-(1,5-a)-pyrimidin-7-yl)phenyl)-acetamid |
PL207322B1 (pl) | 2002-05-14 | 2010-11-30 | Adamed Społka Z Ograniczoną Odpowiedzialnością | Sposób wytwarzania zaleplonu |
CZ20023575A3 (cs) * | 2002-10-25 | 2004-01-14 | Léčiva, A.S. | Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu) |
-
2002
- 2002-08-01 JP JP2003516460A patent/JP2005523874A/ja active Pending
- 2002-08-01 CZ CZ200471A patent/CZ200471A3/cs unknown
- 2002-08-01 PL PL02374176A patent/PL374176A1/xx unknown
- 2002-08-01 US US10/211,461 patent/US6852858B2/en not_active Expired - Fee Related
- 2002-08-01 MX MXPA04001035A patent/MXPA04001035A/es unknown
- 2002-08-01 CA CA002453751A patent/CA2453751A1/en not_active Abandoned
- 2002-08-01 EP EP02765928A patent/EP1430054A4/en not_active Withdrawn
- 2002-08-01 WO PCT/US2002/024553 patent/WO2003011228A2/en not_active Application Discontinuation
- 2002-08-01 IL IL16007602A patent/IL160076A0/xx unknown
- 2002-08-01 SK SK47-2004A patent/SK472004A3/sk unknown
- 2002-08-01 HU HU0402253A patent/HUP0402253A3/hu unknown
-
2004
- 2004-01-28 IS IS7128A patent/IS7128A/is unknown
- 2004-02-23 HR HR20040180A patent/HRP20040180A2/hr not_active Application Discontinuation
- 2004-02-27 NO NO20040887A patent/NO20040887L/no not_active Application Discontinuation
- 2004-09-27 US US10/952,151 patent/US7348429B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20050065168A1 (en) | 2005-03-24 |
PL374176A1 (en) | 2005-10-03 |
EP1430054A2 (en) | 2004-06-23 |
HUP0402253A3 (en) | 2005-12-28 |
HUP0402253A2 (hu) | 2005-02-28 |
WO2003011228A2 (en) | 2003-02-13 |
US7348429B2 (en) | 2008-03-25 |
US6852858B2 (en) | 2005-02-08 |
CA2453751A1 (en) | 2003-02-13 |
SK472004A3 (en) | 2004-12-01 |
NO20040887L (no) | 2004-02-27 |
EP1430054A4 (en) | 2005-06-22 |
CZ200471A3 (cs) | 2004-11-10 |
WO2003011228A3 (en) | 2003-10-30 |
IL160076A0 (en) | 2004-06-20 |
US20030130291A1 (en) | 2003-07-10 |
JP2005523874A (ja) | 2005-08-11 |
HRP20040180A2 (en) | 2004-12-31 |
IS7128A (is) | 2004-01-28 |
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