WO2007026376A3 - A novel process for preparation of highly pure crystalline hydrochlorothiazide - Google Patents

A novel process for preparation of highly pure crystalline hydrochlorothiazide Download PDF

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Publication number
WO2007026376A3
WO2007026376A3 PCT/IN2006/000146 IN2006000146W WO2007026376A3 WO 2007026376 A3 WO2007026376 A3 WO 2007026376A3 IN 2006000146 W IN2006000146 W IN 2006000146W WO 2007026376 A3 WO2007026376 A3 WO 2007026376A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrochlorothiazide
preparation
pure crystalline
highly pure
novel process
Prior art date
Application number
PCT/IN2006/000146
Other languages
French (fr)
Other versions
WO2007026376A2 (en
Inventor
Arul Ramakrishnan
Gobind Singh Kapkoti
Dnyaneshwar Tuaram Singare
Neeraj Kumar
Original Assignee
Unichem Lab Ltd
Arul Ramakrishnan
Gobind Singh Kapkoti
Dnyaneshwar Tuaram Singare
Neeraj Kumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unichem Lab Ltd, Arul Ramakrishnan, Gobind Singh Kapkoti, Dnyaneshwar Tuaram Singare, Neeraj Kumar filed Critical Unichem Lab Ltd
Publication of WO2007026376A2 publication Critical patent/WO2007026376A2/en
Publication of WO2007026376A3 publication Critical patent/WO2007026376A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
    • C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
    • C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
    • C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
    • C07D285/28—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

This invention relates to a process for the preparation and purification of a pure crystalline Hydrochlorothiazide with overall purity 99.9% or greater and single impurity below 0.1%. This is a two step process. In first step crude hydrochlorothiazide is prepared which is in second step purified to get highly pure crystalline hydrochlorothiazide.
PCT/IN2006/000146 2005-08-29 2006-04-27 A novel process for preparation of highly pure crystalline hydrochlorothiazide WO2007026376A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1017/MUM/2005 2005-08-29
IN1017MU2005 2005-08-29

Publications (2)

Publication Number Publication Date
WO2007026376A2 WO2007026376A2 (en) 2007-03-08
WO2007026376A3 true WO2007026376A3 (en) 2008-04-10

Family

ID=37809293

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2006/000146 WO2007026376A2 (en) 2005-08-29 2006-04-27 A novel process for preparation of highly pure crystalline hydrochlorothiazide

Country Status (1)

Country Link
WO (1) WO2007026376A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102329283B (en) * 2011-07-14 2013-08-07 海南锦瑞制药股份有限公司 Hydrochlorothiazide crystal and candesartan cilexetil hydrochlorothiazide medicinal combination thereof
CN103396381B (en) * 2013-07-31 2016-06-29 安阳九州药业有限责任公司 A kind of production method of hydrochlorothiazide
CN114369073B (en) * 2021-12-01 2024-03-26 润都制药(荆门)有限公司 Method for preparing high-purity hydrochlorothiazide
EP4234542A1 (en) 2022-02-28 2023-08-30 Zaklady Farmaceutyczne Polpharma S.A. A process for manufacturing high purity hydrochlorothiazide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163645A (en) * 1964-09-25 1964-12-29 Ciba Geigy Corp Derivatives of 3, 4-dihydro-2-h-[1, 2, 4]-benzothiadiazine-1, 1-dioxides
CH393339A (en) * 1959-07-20 1965-06-15 Simes Process for the preparation of 6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH393339A (en) * 1959-07-20 1965-06-15 Simes Process for the preparation of 6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
US3163645A (en) * 1964-09-25 1964-12-29 Ciba Geigy Corp Derivatives of 3, 4-dihydro-2-h-[1, 2, 4]-benzothiadiazine-1, 1-dioxides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] MATSUMOTO I.: "Preparation of 5-chloro-2,4-disulfamoylaniline by the use of 1-nitro-2,4,5-trichlorobenzene", Database accession no. (1963:428557) *
YAKUGAKU ZASSHI, vol. 83, 1963, pages 327 - 331 *

Also Published As

Publication number Publication date
WO2007026376A2 (en) 2007-03-08

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