IL160076A0 - Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process - Google Patents

Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process

Info

Publication number
IL160076A0
IL160076A0 IL16007602A IL16007602A IL160076A0 IL 160076 A0 IL160076 A0 IL 160076A0 IL 16007602 A IL16007602 A IL 16007602A IL 16007602 A IL16007602 A IL 16007602A IL 160076 A0 IL160076 A0 IL 160076A0
Authority
IL
Israel
Prior art keywords
zaleplon
cyanopyrazolo
ethylacetamide
pyrimidin
purifying
Prior art date
Application number
IL16007602A
Other languages
English (en)
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/170,673 external-priority patent/US6884888B2/en
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of IL160076A0 publication Critical patent/IL160076A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
IL16007602A 2001-08-01 2002-08-01 Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process IL160076A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30939101P 2001-08-01 2001-08-01
US31790701P 2001-09-06 2001-09-06
US38819902P 2002-06-12 2002-06-12
US10/170,673 US6884888B2 (en) 2001-06-12 2002-06-12 Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon)
PCT/US2002/024553 WO2003011228A2 (en) 2001-08-01 2002-08-01 Purification and crystalline forms of zaleplon

Publications (1)

Publication Number Publication Date
IL160076A0 true IL160076A0 (en) 2004-06-20

Family

ID=27496922

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16007602A IL160076A0 (en) 2001-08-01 2002-08-01 Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process

Country Status (14)

Country Link
US (2) US6852858B2 (xx)
EP (1) EP1430054A4 (xx)
JP (1) JP2005523874A (xx)
CA (1) CA2453751A1 (xx)
CZ (1) CZ200471A3 (xx)
HR (1) HRP20040180A2 (xx)
HU (1) HUP0402253A3 (xx)
IL (1) IL160076A0 (xx)
IS (1) IS7128A (xx)
MX (1) MXPA04001035A (xx)
NO (1) NO20040887L (xx)
PL (1) PL374176A1 (xx)
SK (1) SK472004A3 (xx)
WO (1) WO2003011228A2 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0113244A (pt) * 2000-08-03 2003-07-08 Wyeth Corp Polimorfos de zaleplon; métodos e processos para a preparação dos mesmos; composição farmacêutica
US20050032818A1 (en) * 2001-06-12 2005-02-10 Entire Interest N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon
US6852858B2 (en) * 2001-08-01 2005-02-08 Biogal Gyogyszergyar Rt. Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
EP1406871A4 (en) * 2001-06-12 2005-01-26 Biogal Gyogyszergyar PROCESS FOR THE PRODUCTION OF N- 3- (3-CYANOPYRAZOLO 1,5-A] PYRIMIDINE-7-YLE) PHENYL] -N-ETHYLACETAMIDE (ZALEPLON)
CA2475592A1 (en) * 2002-02-15 2003-08-21 Biogal Gyogyszergyar Rt. Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom
CZ20023575A3 (cs) * 2002-10-25 2004-01-14 Léčiva, A.S. Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)
DE112004001615T5 (de) 2003-09-04 2006-06-14 Cipla Ltd. Zaleplon-Synthese
ES2338659T3 (es) * 2004-01-14 2010-05-11 Mallinckrodt, Inc. Metodo de dos fases para la sintesis de pirazolopirimidinas seleccionadas.
HUP0400325A3 (en) * 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
JPWO2006062129A1 (ja) * 2004-12-08 2008-06-12 株式会社クラレ （５α，７α）−３−スピロ−２’−（１’，３’−ジオキソラン）−２４−オキソコレスト−２２−エン−７−イルベンゾアートの製造方法
WO2007043939A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a
US7761955B1 (en) * 2007-08-30 2010-07-27 Hiltz Erik D Dual port cleaning and extraction apparatus
US8171598B1 (en) 2010-07-26 2012-05-08 Erik Daniel Hiltz Dual port cleaning and extraction apparatus
RU2021125455A (ru) 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
DE10004790B4 (de) 2000-02-01 2004-09-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung von Zaleplon, Verfahren zu seiner Herstellung und seine Verwendung
AU5066101A (en) 2000-04-13 2001-10-30 Synthon B.V. Modified release formulations containing a hypnotic agent
BR0113244A (pt) * 2000-08-03 2003-07-08 Wyeth Corp Polimorfos de zaleplon; métodos e processos para a preparação dos mesmos; composição farmacêutica
AR029780A1 (es) 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
EP1406871A4 (en) 2001-06-12 2005-01-26 Biogal Gyogyszergyar PROCESS FOR THE PRODUCTION OF N- 3- (3-CYANOPYRAZOLO 1,5-A] PYRIMIDINE-7-YLE) PHENYL] -N-ETHYLACETAMIDE (ZALEPLON)
US6852858B2 (en) 2001-08-01 2005-02-08 Biogal Gyogyszergyar Rt. Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
EP1476446B1 (de) * 2002-02-14 2007-08-01 Cilag AG Verfahren zur herstellung von n-ethyl-n-(3-(3-cyanopyrazolo-(1,5-a)-pyrimidin-7-yl)phenyl)-acetamid
PL207322B1 (pl) 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu
CZ20023575A3 (cs) * 2002-10-25 2004-01-14 Léčiva, A.S. Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)

Also Published As

Publication number Publication date
US7348429B2 (en) 2008-03-25
EP1430054A2 (en) 2004-06-23
WO2003011228A3 (en) 2003-10-30
HUP0402253A3 (en) 2005-12-28
IS7128A (is) 2004-01-28
EP1430054A4 (en) 2005-06-22
HRP20040180A2 (en) 2004-12-31
JP2005523874A (ja) 2005-08-11
NO20040887L (no) 2004-02-27
SK472004A3 (en) 2004-12-01
US20030130291A1 (en) 2003-07-10
HUP0402253A2 (hu) 2005-02-28
WO2003011228A2 (en) 2003-02-13
MXPA04001035A (es) 2004-06-22
US20050065168A1 (en) 2005-03-24
CZ200471A3 (cs) 2004-11-10
US6852858B2 (en) 2005-02-08
CA2453751A1 (en) 2003-02-13
PL374176A1 (en) 2005-10-03

Similar Documents

Publication Publication Date Title
IL160076A0 (en) Process for purifying n-[3-(3-cyanopyrazolo{1,5-a} pyrimidin-7-yl) phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
DK0776898T3 (da) Fremgangsmådeforbedring ved syntesen af N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamid
EE05222B1 (et) Triasolo(4,5-d)primidiinihendi kristalne ja amorfne vorm, meetod selle valmistamiseks ning kasutamine
HK1083844A1 (en) N-[3-(3-substituted-pyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-sulfonamides, and compositions, and methods related thereto
IL176737A0 (en) Pyrazolo[1,5-a] pyrimidin-7-yl-amine derivatives for use in the treatment of protein kinase dependent diseases
PT1674456E (pt) Utilização de 2-fluoro-3-cetoésteres para preparar 3-fluoro- 6,7,8,9-tetra-hidro-4-h-pirimido[1,2-a]pirimidin-4-onas
PL372942A1 (en) Process for the production of n-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl)phenyl]-n-ethylacetamide (zaleplon)
IL175753A0 (en) PROCESSES FOR THE PREPARATION OF PYRAZOLO [1,5-a]-1,3,5-TRIAZINES AND INTERMEDIATES THEREOF
ID29790A (id) PENGGUNAAN IMIDAZO(1,5-a)-PIRIDO(3,2-e)-PIRAZINON SEBAGAI OBAT
IL144516A0 (en) PROCESS FOR THE PREPARATION OF PYRAZOLO [4,3-d] PYRIMIDIN-7-ONE COMPOUNDS AND INTERMEDIATES THEREOF
CA2417875A1 (en) Polymorphs of zaleplon and methods for the preparation thereof
EG22775A (en) Process for the preparation of pyrazolo (f,5-d) pyrimidin 7 ones-3-pyridylsulphonyl compounds and intermediates thereof
ATE269082T1 (de) Polymorphe des n-methyl-n-(3-(2-thienylcarbonyl)- pyrazol(1,5-a)pyrimidin-7-yl phenyl)acetamid und zusammenstellungen und diesbezügliche methoden
MXPA03008894A (es) Uso de compuestos de imidazo[1,2-a]-piridin-3-il-amidas e imidazo [1,2-a]-piridin-3-il-aminas sustituidas como medicamentos.
HUP0400325A3 (en) Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
WO2006070244A3 (en) A process for the preparation of zaleplon
GB0110251D0 (en) Process for the preparation of pyrazolo[4,4-d]Pyrimidin-7-one compounds and intermediates thereof
PL374911A1 (en) Process for the preparation of zaleplon
GB0107526D0 (en) Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-one compounds and intermediates thereof
WO2008068600A3 (en) An improved process for the preparation of zaleplo
EE200100700A (et) Asendatud [1,4]diasepino[6,7,1-hi]indool-4-oonidevalmistamismeetod
ZA200106161B (en) Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof.
TWI318628B (en) Novel pyrrolo[2,1-c][1,4] benzodiazepine-indole derivatives, and preparation process and uses of the same
IL203601A (en) 6-Hello-7-History (optionally converted amino) -Pyrazolo [15, - a] pyrimidine and its use in drug preparation