WO2006070244A3 - A process for the preparation of zaleplon - Google Patents
A process for the preparation of zaleplon Download PDFInfo
- Publication number
- WO2006070244A3 WO2006070244A3 PCT/IB2005/003814 IB2005003814W WO2006070244A3 WO 2006070244 A3 WO2006070244 A3 WO 2006070244A3 IB 2005003814 W IB2005003814 W IB 2005003814W WO 2006070244 A3 WO2006070244 A3 WO 2006070244A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- zaleplon
- preparation
- acetamide
- novel
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention relates to a novel and commercially feasible process for the preparation of pyrazolo[1,5-a]pyrimidine compound Zaleplon, wherein a novel intermediate 7-(3bromophenyl)-3,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile is coupled with acetamide to yield a N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]acetamide which on ethylation gives Zaleplon.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1252MU2004 | 2004-11-22 | ||
IN1252/MUM/2004 | 2005-01-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006070244A2 WO2006070244A2 (en) | 2006-07-06 |
WO2006070244A3 true WO2006070244A3 (en) | 2007-03-22 |
Family
ID=36615293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/003814 WO2006070244A2 (en) | 2004-11-22 | 2005-12-19 | A process for the preparation of zaleplon |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006070244A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104341426A (en) * | 2014-09-25 | 2015-02-11 | 安润医药科技(苏州)有限公司 | Method for synthesizing zaleplon |
CN104359992B (en) * | 2014-12-02 | 2016-05-04 | 湖北华世通潜龙药业有限公司 | Adopt the method for high-efficient liquid phase chromatogram technique analysis injection ACV |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
US5714607A (en) * | 1995-12-01 | 1998-02-03 | American Cyanamid Company | Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide |
US20030040522A1 (en) * | 2001-06-12 | 2003-02-27 | Ferenc Korodi | Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon) |
WO2005070931A1 (en) * | 2004-01-14 | 2005-08-04 | Mallinckrodt Inc. | Two-phase method for the synthesis of selected pyrazolopyrimidines |
WO2005073235A2 (en) * | 2004-02-02 | 2005-08-11 | Richter Gedeon Vegyészeti Gyár Rt. | Process for the synthesis of n- [3-(3-cyanopyrazolo [1,5a] pyrimidin-7-yl)-phenyl]-n-ethyl-acetamide |
-
2005
- 2005-12-19 WO PCT/IB2005/003814 patent/WO2006070244A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
US5714607A (en) * | 1995-12-01 | 1998-02-03 | American Cyanamid Company | Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide |
US20030040522A1 (en) * | 2001-06-12 | 2003-02-27 | Ferenc Korodi | Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon) |
WO2005070931A1 (en) * | 2004-01-14 | 2005-08-04 | Mallinckrodt Inc. | Two-phase method for the synthesis of selected pyrazolopyrimidines |
WO2005073235A2 (en) * | 2004-02-02 | 2005-08-11 | Richter Gedeon Vegyészeti Gyár Rt. | Process for the synthesis of n- [3-(3-cyanopyrazolo [1,5a] pyrimidin-7-yl)-phenyl]-n-ethyl-acetamide |
Also Published As
Publication number | Publication date |
---|---|
WO2006070244A2 (en) | 2006-07-06 |
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