WO2008068600A3 - An improved process for the preparation of zaleplo - Google Patents

An improved process for the preparation of zaleplo Download PDF

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Publication number
WO2008068600A3
WO2008068600A3 PCT/IB2007/003787 IB2007003787W WO2008068600A3 WO 2008068600 A3 WO2008068600 A3 WO 2008068600A3 IB 2007003787 W IB2007003787 W IB 2007003787W WO 2008068600 A3 WO2008068600 A3 WO 2008068600A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
zaleplo
formula
zaleplon
Prior art date
Application number
PCT/IB2007/003787
Other languages
French (fr)
Other versions
WO2008068600A2 (en
Inventor
Mahender Rao Siripragada
Sampath Kumar Upparapalli
Thirumurugan Kunchithapatham
Mannathan Subramaniyan
Original Assignee
Orchid Chemicals & Pharm Ltd
Mahender Rao Siripragada
Sampath Kumar Upparapalli
Thirumurugan Kunchithapatham
Mannathan Subramaniyan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals & Pharm Ltd, Mahender Rao Siripragada, Sampath Kumar Upparapalli, Thirumurugan Kunchithapatham, Mannathan Subramaniyan filed Critical Orchid Chemicals & Pharm Ltd
Publication of WO2008068600A2 publication Critical patent/WO2008068600A2/en
Publication of WO2008068600A3 publication Critical patent/WO2008068600A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of N-[3-(3-cyanopyrazolo[ 1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (Zaleplon) of formula (I), more particularly the present invention relates to a method for the purification of Zaleplon of formula (I), which is useful in medicine as an anxiolytic, sedative and skeletal muscle relaxing agent. Formula (I)
PCT/IB2007/003787 2006-12-06 2007-12-06 An improved process for the preparation of zaleplo WO2008068600A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2255CH2006 2006-12-06
IN2255/CHE/2006 2006-12-06
IN701/CHE/2007 2007-04-03
IN701CH2007 2007-04-03

Publications (2)

Publication Number Publication Date
WO2008068600A2 WO2008068600A2 (en) 2008-06-12
WO2008068600A3 true WO2008068600A3 (en) 2008-08-07

Family

ID=39492679

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/003787 WO2008068600A2 (en) 2006-12-06 2007-12-06 An improved process for the preparation of zaleplo

Country Status (1)

Country Link
WO (1) WO2008068600A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105622615A (en) * 2015-12-30 2016-06-01 上海天慈国际药业有限公司 Novel method for synthesizing zaleplon

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208846A1 (en) * 1983-06-23 1987-01-21 American Cyanamid Company [7-(3-Disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
EP0776898A1 (en) * 1995-12-01 1997-06-04 American Cyanamid Company Process improvement in the synthesis of N-[3-(3-cyanopyrazolo [1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0208846A1 (en) * 1983-06-23 1987-01-21 American Cyanamid Company [7-(3-Disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
EP0776898A1 (en) * 1995-12-01 1997-06-04 American Cyanamid Company Process improvement in the synthesis of N-[3-(3-cyanopyrazolo [1,5-a]pyrimidin-7-yl)phenyl]-N-ethyl-acetamide

Also Published As

Publication number Publication date
WO2008068600A2 (en) 2008-06-12

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