YU39602A - Višestepeni postupak za dobijanje deferoksamin metilsulfonil soli visoke čistoće - Google Patents
Višestepeni postupak za dobijanje deferoksamin metilsulfonil soli visoke čistoćeInfo
- Publication number
- YU39602A YU39602A YU39602A YUP39602A YU39602A YU 39602 A YU39602 A YU 39602A YU 39602 A YU39602 A YU 39602A YU P39602 A YUP39602 A YU P39602A YU 39602 A YU39602 A YU 39602A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- deferoxamine
- mesylate salt
- preparation
- highly pure
- multistage process
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- IDDIJAWJANBQLJ-UHFFFAOYSA-N desferrioxamine B mesylate Chemical class [H+].CS([O-])(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN IDDIJAWJANBQLJ-UHFFFAOYSA-N 0.000 title abstract 2
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 abstract 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 3
- 238000001179 sorption measurement Methods 0.000 abstract 3
- 239000012458 free base Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 238000001556 precipitation Methods 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 229960000958 deferoxamine Drugs 0.000 abstract 1
- 238000003795 desorption Methods 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Predmetni pronalazak obezbedjuje postupak za prečišćavanje u kome se deferoksamin B, proizveden od strane mikroorganizama i koji je pomešan sa drugim polihidroksamatima stvorenih od strane mikroorganizama, može prevesti u svoju metilsulfonil so, koja je oslobodjena prisustva drugih polihidroksamata, kao i jona hlora. Postupak uključuje adsorbciju i desorbciju deferoksamina B na adsorbcionoj smoli, direktno taloženje deforksamina u vidu slobodne baze iz eluenta iz adsorpcione smole, reakciju deferoksamina u obliku slobodne baze sa metansulfonsom kiselinom i izolovanje deferoksamin B metilsulfonila putem taloženja. Ovaj postupak minimizuje razlaganje deferoksamina B.[The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate sait by precipitation. This process minimizes decomposition of deferoxamine B.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9904454A HU227315B1 (en) | 1999-12-01 | 1999-12-01 | Process having several steps for producing deferoxamine mesilate of high purity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU39602A true YU39602A (sh) | 2005-07-19 |
Family
ID=90000087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU39602A YU39602A (sh) | 1999-12-01 | 2000-11-30 | Višestepeni postupak za dobijanje deferoksamin metilsulfonil soli visoke čistoće |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1235791A4 (sh) |
| JP (1) | JP2003515579A (sh) |
| KR (1) | KR20020067044A (sh) |
| CN (1) | CN1433399A (sh) |
| AU (1) | AU1935101A (sh) |
| CA (1) | CA2392925A1 (sh) |
| CZ (1) | CZ20021823A3 (sh) |
| HU (1) | HU227315B1 (sh) |
| MX (1) | MXPA02005377A (sh) |
| PL (1) | PL355328A1 (sh) |
| RU (1) | RU2002114073A (sh) |
| SK (1) | SK7472002A3 (sh) |
| WO (1) | WO2001040164A1 (sh) |
| YU (1) | YU39602A (sh) |
| ZA (1) | ZA200204030B (sh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111544374A (zh) * | 2020-05-13 | 2020-08-18 | 中国人民解放军总医院第四医学中心 | 注射用甲磺酸去铁胺在治疗增龄性骨丢失及骨髓干细胞衰老中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH438351A (de) * | 1959-09-25 | 1967-06-30 | Ciba Geigy | Verfahren zur Herstellung neuer Wuchsstoffe |
| FR1898M (fr) * | 1961-04-07 | 1963-07-08 | Ciba Geigy | Nouvelle substance utilisable en thérapeutique. |
| WO1993003045A1 (en) * | 1991-08-09 | 1993-02-18 | The Regents Of The University Of California | Process for purer organic metal ion chelate complexes |
| US5254724A (en) * | 1991-10-30 | 1993-10-19 | University Of Florida Research Foundation, Inc. | Method for synthesis of desferrioxamine B, analogs and homologs thereof |
| HU214452B (hu) * | 1992-06-01 | 1998-03-30 | BIOGAL Gyógyszergyár Rt. | Eljárás nagytisztaságú deferoxamin-B-sók előállítására |
-
1999
- 1999-12-01 HU HU9904454A patent/HU227315B1/hu not_active IP Right Cessation
-
2000
- 2000-11-30 RU RU2002114073/04A patent/RU2002114073A/ru unknown
- 2000-11-30 KR KR1020027007014A patent/KR20020067044A/ko not_active Application Discontinuation
- 2000-11-30 WO PCT/US2000/032574 patent/WO2001040164A1/en not_active Application Discontinuation
- 2000-11-30 CN CN00818750A patent/CN1433399A/zh active Pending
- 2000-11-30 SK SK747-2002A patent/SK7472002A3/sk not_active Application Discontinuation
- 2000-11-30 JP JP2001541852A patent/JP2003515579A/ja active Pending
- 2000-11-30 AU AU19351/01A patent/AU1935101A/en not_active Abandoned
- 2000-11-30 PL PL00355328A patent/PL355328A1/xx unknown
- 2000-11-30 CA CA002392925A patent/CA2392925A1/en not_active Abandoned
- 2000-11-30 CZ CZ20021823A patent/CZ20021823A3/cs unknown
- 2000-11-30 EP EP00982299A patent/EP1235791A4/en not_active Withdrawn
- 2000-11-30 MX MXPA02005377A patent/MXPA02005377A/es unknown
- 2000-11-30 YU YU39602A patent/YU39602A/sh unknown
-
2002
- 2002-05-21 ZA ZA200204030A patent/ZA200204030B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU227315B1 (en) | 2011-03-28 |
| MXPA02005377A (es) | 2002-12-05 |
| KR20020067044A (ko) | 2002-08-21 |
| PL355328A1 (en) | 2004-04-19 |
| EP1235791A1 (en) | 2002-09-04 |
| EP1235791A4 (en) | 2006-03-08 |
| AU1935101A (en) | 2001-06-12 |
| CA2392925A1 (en) | 2001-06-07 |
| HU9904454D0 (en) | 2000-02-28 |
| SK7472002A3 (en) | 2003-03-04 |
| CN1433399A (zh) | 2003-07-30 |
| WO2001040164A1 (en) | 2001-06-07 |
| JP2003515579A (ja) | 2003-05-07 |
| HUP9904454A2 (hu) | 2001-08-28 |
| RU2002114073A (ru) | 2004-01-20 |
| ZA200204030B (en) | 2003-05-21 |
| CZ20021823A3 (cs) | 2003-02-12 |
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