HUP9904329A2 - Herpeszvirus saimiri mint vírusvektor - Google Patents

Herpeszvirus saimiri mint vírusvektor

Info

Publication number
HUP9904329A2
HUP9904329A2 HU9904329A HUP9904329A HUP9904329A2 HU P9904329 A2 HUP9904329 A2 HU P9904329A2 HU 9904329 A HU9904329 A HU 9904329A HU P9904329 A HUP9904329 A HU P9904329A HU P9904329 A2 HUP9904329 A2 HU P9904329A2
Authority
HU
Hungary
Prior art keywords
herpesvirus saimiri
mutation
site
harbors
viral
Prior art date
Application number
HU9904329A
Other languages
English (en)
Inventor
Alexander Fred Markham
David Mark Meredith
Original Assignee
The University Of Leeds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Leeds filed Critical The University Of Leeds
Publication of HUP9904329A2 publication Critical patent/HUP9904329A2/hu
Publication of HUP9904329A3 publication Critical patent/HUP9904329A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16411—Rhadinovirus, e.g. human herpesvirus 8
    • C12N2710/16422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16411—Rhadinovirus, e.g. human herpesvirus 8
    • C12N2710/16441—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16443—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

A találmány tárgya Herpesvirűs saimiri, amely egy, a vírűsszapőrődásáhőz szükséges fehérjét kódőló, legalább egy génben legalábbegy műtációt hőrdőz, amely műtáció megakadályőzza a vírűs szapőrődásátegy hűmán sejtben, vagy őlyan Herpesvirűs saimiri, amely legalább egyműtációt hőrdőz a következő gének közül legalább egyben: ORF4. OR14,ORF15, ORF16 vagy ORF51. Herpesvirűs saimiri, amely vagy alkalmaslegalább egy, előre kiválasztőtt, heterőlóg, DNS-fragmensinszerciójára egy deléciós hellyel szőmszédősan, vagy az egyetlenkódőló szakasz és egy nemkódőló szakasz közötti kapcsőlódási helyre,vagy tartalmazza a fragmenst ezen a helyen. A találmány szerintimegőldás alkalmazható génszállító rendszerként, amely képes genetikaianyag sejten belüli szállítására, és amely szállítás biztőnságősanvégrehajtható és így nem jár citőpatőlógiás következményekkel. ŕ
HU9904329A 1996-09-04 1997-09-04 Herpesvirus saimiri as viral vector HUP9904329A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9618477.5A GB9618477D0 (en) 1996-09-04 1996-09-04 Gene therapy

Publications (2)

Publication Number Publication Date
HUP9904329A2 true HUP9904329A2 (hu) 2000-04-28
HUP9904329A3 HUP9904329A3 (en) 2002-01-28

Family

ID=10799414

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904329A HUP9904329A3 (en) 1996-09-04 1997-09-04 Herpesvirus saimiri as viral vector

Country Status (18)

Country Link
US (1) US6379967B1 (hu)
EP (1) EP0939828B1 (hu)
JP (1) JP2000517191A (hu)
KR (1) KR20000068461A (hu)
CN (1) CN1237209A (hu)
AT (1) ATE342997T1 (hu)
AU (1) AU737197B2 (hu)
BR (1) BR9711998A (hu)
CA (1) CA2264956A1 (hu)
CZ (1) CZ69799A3 (hu)
DE (1) DE69736838T2 (hu)
ES (1) ES2274541T3 (hu)
GB (1) GB9618477D0 (hu)
HU (1) HUP9904329A3 (hu)
IL (1) IL128635A0 (hu)
NZ (1) NZ334323A (hu)
SG (1) SG91252A1 (hu)
WO (1) WO1998010083A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9826069D0 (en) 1998-11-28 1999-01-20 Univ Leeds HIV vaccine
GB9903694D0 (en) 1999-02-19 1999-04-14 Univ Leeds Latency-associated regulatory region
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
WO2004009768A2 (en) * 2002-07-18 2004-01-29 Invitrogen Corporation Viral vectors containing recombination sites
WO2005014796A2 (en) 2003-08-08 2005-02-17 Invitrogen Corporation Methods and compositions for seamless cloning of nucleic acid molecules
ATE469984T1 (de) 2003-12-01 2010-06-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
SI1912675T1 (sl) 2005-07-25 2014-07-31 Emergent Product Development Seattle, Llc zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20
MX363905B (es) 2006-06-12 2019-04-08 Aptevo Res & Development Llc Proteinas de union multivalentes monocatenarias con funcion efectora.
AU2008287195A1 (en) * 2007-07-06 2009-02-19 Emergent Product Development Seattle, Llc Binding peptides having a C-terminally disposed specific binding domain
EP2132228B1 (en) * 2008-04-11 2011-06-22 Emergent Product Development Seattle, LLC Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
WO2017053469A2 (en) 2015-09-21 2017-03-30 Aptevo Research And Development Llc Cd3 binding polypeptides
WO2018048869A1 (en) * 2016-09-06 2018-03-15 Bioventures, Llc Compositions and methods for generating reversion free attenuated and/or replication incompetent vaccine vectors
CN107653345B (zh) * 2017-11-08 2021-04-27 中国人民解放军军事医学科学院野战输血研究所 猴b病毒实时荧光定量pcr方法及其通用引物、mgb探针与试剂盒
RU2771081C2 (ru) * 2020-08-25 2022-04-26 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) Рекомбинантный штамм Herpesvirus saimiri для получения популяций иммортализованных аутологичных Т-лимфоцитов, экспрессирующих парные химерные рецепторы против опухолевых антигенов CD44 и CD133

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672344A (en) * 1987-12-30 1997-09-30 The Regents Of The University Of Michigan Viral-mediated gene transfer system
JPH04503300A (ja) * 1988-10-06 1992-06-18 デイナ・フアーバー・キヤンサー・インステイテユート Ｈ．ｓａｉｍｉｒｉ―ｈｔｌｖ―ｘ領域ベクター
DE3834157A1 (de) * 1988-10-07 1990-04-19 Behringwerke Ag Selektionierbare vektoren fuer humane t-zellen

Also Published As

Publication number Publication date
AU737197B2 (en) 2001-08-09
EP0939828B1 (en) 2006-10-18
SG91252A1 (en) 2002-09-17
CA2264956A1 (en) 1998-03-12
EP0939828A1 (en) 1999-09-08
KR20000068461A (ko) 2000-11-25
DE69736838T2 (de) 2007-10-31
NZ334323A (en) 2000-06-23
ES2274541T3 (es) 2007-05-16
AU4307197A (en) 1998-03-26
IL128635A0 (en) 2000-01-31
US6379967B1 (en) 2002-04-30
ATE342997T1 (de) 2006-11-15
CN1237209A (zh) 1999-12-01
JP2000517191A (ja) 2000-12-26
DE69736838D1 (de) 2006-11-30
HUP9904329A3 (en) 2002-01-28
BR9711998A (pt) 2000-01-18
WO1998010083A1 (en) 1998-03-12
CZ69799A3 (cs) 1999-08-11
GB9618477D0 (en) 1996-10-16

Similar Documents

Publication Publication Date Title
HUP9904329A2 (hu) Herpeszvirus saimiri mint vírusvektor
AP1678A (en) Novel modified nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems.
Franz et al. Minos, a new transposable element from Drosophila hydei, is a member of the Tc1-like family of transposons.
MX9709549A (es) Adenovirus recombinantes, su uso para preparar aav, linea celular complementaria y composiciones farmaceuticas que los contienen.
NZ500740A (en) Recombinant lentivirus-based gene transfer vectors comprising 3 vectors from Equine Infectious Anemia Virus (EIAV)
DE69430071D1 (de) Herstellung von rekombinanten proteinen in einem rinderadenovirus-expressionsvektorsystem
AUPN477695A0 (en) Gene therapy
NZ337676A (en) Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
ZA942778B (en) Recombinant viruses, and their preparation and use in gene therapy.
TR200401186T4 (tr) Rekombinant bir RNA-virüs oluşumunu yönlendirebilen nükleik asit sekansları içerikli suni kromozom yapıları.
WO2000034497A3 (en) Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors
ES555124A0 (es) Procedimiento de preparar particulas que contienen secuencias de aminoacidos y que tienen propiedades inmunogenas
DK0843731T3 (da) Adenovirusvektorer til genterapi
HUP0102861A2 (hu) Attenuált lóherpeszvírus
EP0256677A3 (en) Pseudorabies virus recombinants and their use in the production of proteins
AU582288B2 (en) Vector and method for achieving high level expression in eukaryotic cells
GB9816856D0 (en) Cell lines for virus growth
DE69417717T2 (de) Impstoff zum Schutze von Pferden gegen Pferdeherpesvirus-Infektionen
ES2109194B1 (es) Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.
HUP9904201A1 (hu) Génterápiában használható, egy exogén nukleinsavat genomjában beépítve tartalmazó rekombináns vírus és egy nem virális és nem plazmid transzfektáló szer kombinációját tartalmazó transzfektáló készítmény
RU2240348C2 (ru) Последовательность нуклеиновой кислоты, которая обеспечивает поддержание эписомальной репликации в клетке млекопитающего, и вектор ее включающий
ATE259421T1 (de) Dna-virus-vektoren und verfahren zu ihrer herstellung
WO1993018151A1 (fr) Element transposable originaire d'une bacterie du genre brevibacterium
Ireland et al. Small nuclear RNAs from Drosophila KC-H cells; characterization and comparison with mammalian RNAs
EP1229124A4 (en) NUCLEIC ACID CONVEYOR CONTAINING POLYPEPTIDE AND RECOMBINANT VIRAL VECTOR