HUP9904009A2 - Új eljárás és ebben alkalmazható új vegyületek - Google Patents

Új eljárás és ebben alkalmazható új vegyületek

Info

Publication number
HUP9904009A2
HUP9904009A2 HU9904009A HUP9904009A HUP9904009A2 HU P9904009 A2 HUP9904009 A2 HU P9904009A2 HU 9904009 A HU9904009 A HU 9904009A HU P9904009 A HUP9904009 A HU P9904009A HU P9904009 A2 HUP9904009 A2 HU P9904009A2
Authority
HU
Hungary
Prior art keywords
novel compounds
neuraminidase
compounds according
influenza virus
macromolecular
Prior art date
Application number
HU9904009A
Other languages
English (en)
Inventor
Betty Jin
Guy Y. Krippner
Phillip A. Reece
Keith Geoffrey Watson
Wen-Yang Wu
Original Assignee
Biota Scientific Management Pty. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPO3632A external-priority patent/AUPO363296A0/en
Priority claimed from AUPO8539A external-priority patent/AUPO853997A0/en
Application filed by Biota Scientific Management Pty. Ltd. filed Critical Biota Scientific Management Pty. Ltd.
Publication of HUP9904009A2 publication Critical patent/HUP9904009A2/hu
Publication of HUP9904009A3 publication Critical patent/HUP9904009A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Materials Engineering (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A találmány tárgya makrőmőlekűláris vegyület, amelyhez egy vagy többőlyan mőlekűla (neűraminidázkötő) kapcsőlódik, amely az inflűenzavírűs neűraminidáz enzimjének aktív helyéhez kötődik, de mentes aneűraminidáz enzim által történő hasítástól. A találmány kiterjedinflűenzavírűs kiműtatására a találmány szerinti makrőmőlekűlárisvegyületek alkalmazásával, valamint a találmány szerintimakrőmőlekűláris vegyületeket tartalmazó gyógyszerkészítményre. ŕ
HU9904009A 1996-11-14 1997-11-13 Method and novel compounds for use therein HUP9904009A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPO3632A AUPO363296A0 (en) 1996-11-14 1996-11-14 Method and novel compounds for use therein
AUPO8539A AUPO853997A0 (en) 1997-08-14 1997-08-14 Method and novel compounds for use therein
PCT/AU1997/000771 WO1998021243A1 (en) 1996-11-14 1997-11-13 Method and novel compounds for use therein

Publications (2)

Publication Number Publication Date
HUP9904009A2 true HUP9904009A2 (hu) 2000-03-28
HUP9904009A3 HUP9904009A3 (en) 2001-07-30

Family

ID=25645315

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904009A HUP9904009A3 (en) 1996-11-14 1997-11-13 Method and novel compounds for use therein

Country Status (19)

Country Link
US (1) US6680054B1 (hu)
EP (1) EP0951480A4 (hu)
JP (1) JP3691075B2 (hu)
KR (1) KR20000068986A (hu)
CN (1) CN1238783A (hu)
AP (1) AP9901531A0 (hu)
AU (1) AU732916C (hu)
BR (1) BR9714299A (hu)
CA (1) CA2271249C (hu)
CZ (1) CZ167999A3 (hu)
EA (1) EA001603B1 (hu)
HU (1) HUP9904009A3 (hu)
IL (1) IL129762A0 (hu)
IS (1) IS5044A (hu)
NO (1) NO992297L (hu)
NZ (1) NZ335368A (hu)
PL (1) PL333364A1 (hu)
TR (1) TR199901081T2 (hu)
WO (1) WO1998021243A1 (hu)

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US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
AUPP913999A0 (en) 1999-03-12 1999-04-01 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
GB0015324D0 (en) * 2000-06-22 2000-08-16 Biota Scient Management Medicaments
AUPR001000A0 (en) * 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
AUPR879401A0 (en) * 2001-11-09 2001-12-06 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
WO2006090119A1 (en) 2005-02-23 2006-08-31 Lipoxen Technologies Limited Activated sialic acid derivatives for protein derivatisation and conjugation
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
CN105237629B (zh) * 2007-06-25 2019-06-18 图兰恩教育基金管理人 流感抑制组合物和方法
US8999954B2 (en) * 2007-07-03 2015-04-07 Childern's Hospital & Research Center at Oakland Inhibitors of polysialic acid de-N-acetylase and methods for using the same
JP5523313B2 (ja) 2007-07-03 2014-06-18 チルドレンズ ホスピタル アンド リサーチ センター アット オークランド ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用
WO2009006620A1 (en) 2007-07-03 2009-01-08 Children's Hospital & Research Center At Oakland Oligosialic acid derivatives, methods of manufacture, and immunological uses
US20130280204A1 (en) * 2007-08-27 2013-10-24 Massachusetts Institute Of Technology Polymer-Attached Inhibitors of Influenza Virus
US20090076133A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched zanamivir
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
AU2010247141A1 (en) 2009-05-15 2011-12-15 Redx Pharma Plc Redox drug derivatives
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
PL225045B1 (pl) 2012-05-18 2017-02-28 Univ Jagielloński Zastosowanie polimeru chitozanowego do wytwarzania leków do leczenia i profilaktyki infekcji wywołanych przez koronawirusy
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
EP2970397A2 (en) 2013-03-14 2016-01-20 University Of Washington Through Its Center For Commercialization Polypeptides for treating and/or limiting influenza infection
WO2014165536A1 (en) 2013-04-01 2014-10-09 Becton, Dickinson And Company Methods and kits for the diagnosis of influenza
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
JP6486368B2 (ja) 2013-09-06 2019-03-20 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3094352B1 (en) 2014-01-16 2020-09-23 Academia Sinica Compositions and methods for treatment and detection of cancers
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
TWI670078B (zh) 2014-05-27 2019-09-01 中央研究院 抗ｃｄ２０醣抗體及其用途
JP6894239B2 (ja) 2014-05-27 2021-06-30 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 増強された抗体の有効性のための普遍的グリコフォームに関する組成物および方法
WO2015184002A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-her2 glycoantibodies and uses thereof
AU2015267044A1 (en) 2014-05-28 2016-12-15 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
EP3191500A4 (en) 2014-09-08 2018-04-11 Academia Sinica HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3789766A1 (en) 2015-01-24 2021-03-10 Academia Sinica Novel glycan conjugates and methods of use thereof
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US10336784B2 (en) 2016-03-08 2019-07-02 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
US10538592B2 (en) 2016-08-22 2020-01-21 Cho Pharma, Inc. Antibodies, binding fragments, and methods of use
CN113194983A (zh) 2018-09-06 2021-07-30 奇达拉治疗公司 用于治疗病毒感染的组合物及方法
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CN1185223C (zh) * 1995-02-27 2005-01-19 吉里德科学公司 新颖化合物,其合成方法及治疗用途
GB9516276D0 (en) 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
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AUPO104396A0 (en) 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Antiviral linear polymers
AUPP913999A0 (en) * 1999-03-12 1999-04-01 Biota Scientific Management Pty Ltd Novel chemical compounds and their use

Also Published As

Publication number Publication date
NO992297L (no) 1999-07-12
EA001603B1 (ru) 2001-06-25
AU732916B2 (en) 2001-05-03
US6680054B1 (en) 2004-01-20
AU732916C (en) 2002-06-06
JP2001504876A (ja) 2001-04-10
KR20000068986A (ko) 2000-11-25
JP3691075B2 (ja) 2005-08-31
IL129762A0 (en) 2000-02-29
IS5044A (is) 1999-04-30
AP9901531A0 (en) 1999-05-13
TR199901081T2 (xx) 1999-08-23
CN1238783A (zh) 1999-12-15
CZ167999A3 (cs) 1999-10-13
EP0951480A1 (en) 1999-10-27
EA199900459A1 (ru) 1999-12-29
AU4857697A (en) 1998-06-03
EP0951480A4 (en) 2004-07-28
PL333364A1 (en) 1999-12-06
NO992297D0 (no) 1999-05-12
NZ335368A (en) 2001-08-31
CA2271249A1 (en) 1998-05-22
WO1998021243A1 (en) 1998-05-22
HUP9904009A3 (en) 2001-07-30
BR9714299A (pt) 2000-04-25
CA2271249C (en) 2010-07-20

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